| Identification |
|---|
| HMDB Protein ID
| CDBP02082 |
| Secondary Accession Numbers
| Not Available |
| Name
| ADM |
| Description
| Not Available |
| Synonyms
|
- AM
- Adrenomedullin
- PAMP
- ProAM N-terminal 20 peptide
- ProAM-N20
- Proadrenomedullin N-20 terminal peptide
|
| Gene Name
| ADM |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hormone activity |
| Specific Function
| AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| binding |
| protein binding |
| receptor binding |
| hormone activity |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p15.4 |
| SNPs
| ADM |
| Gene Sequence
|
>558 bp
ATGAAGCTGGTTTCCGTCGCCCTGATGTACCTGGGTTCGCTCGCCTTCCTAGGCGCTGAC
ACCGCTCGGTTGGATGTCGCGTCGGAGTTTCGAAAGAAGTGGAATAAGTGGGCTCTGAGT
CGTGGGAAGAGGGAACTGCGGATGTCCAGCAGCTACCCCACCGGGCTCGCTGACGTGAAG
GCCGGGCCTGCCCAGACCCTTATTCGGCCCCAGGACATGAAGGGTGCCTCTCGAAGCCCC
GAAGACAGCAGTCCGGATGCCGCCCGCATCCGAGTCAAGCGCTACCGCCAGAGCATGAAC
AACTTCCAGGGCCTCCGGAGCTTTGGCTGCCGCTTCGGGACGTGCACGGTGCAGAAGCTG
GCACACCAGATCTACCAGTTCACAGATAAGGACAAGGACAACGTCGCCCCCAGGAGCAAG
ATCAGCCCCCAGGGCTACGGCCGCCGGCGCCGGCGCTCCCTGCCCGAGGCCGGCCCGGGT
CGGACTCTGGTGTCTTCTAAGCCACAAGCACACGGGGCTCCAGCCCCCCCGAGTGGAAGT
GCTCCCCACTTTCTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 185 |
| Molecular Weight
| 20420.2 |
| Theoretical pI
| 11.45 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>ADM
MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVK
AGPAQTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKL
AHQIYQFTDKDKDNVAPRSKISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGS
APHFL
|
| External Links |
|---|
| GenBank ID Protein
| 189053568 |
| UniProtKB/Swiss-Prot ID
| P35318 |
| UniProtKB/Swiss-Prot Entry Name
| ADML_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK312893 |
| GeneCard ID
| ADM |
| GenAtlas ID
| ADM |
| HGNC ID
| HGNC:259 |
| References |
|---|
| General References
| Not Available |