| Identification |
|---|
| HMDB Protein ID
| CDBP02077 |
| Secondary Accession Numbers
| Not Available |
| Name
| Fibroblast growth factor 23 |
| Description
| Not Available |
| Synonyms
|
- FGF-23
- Fibroblast growth factor 23 C-terminal peptide
- Fibroblast growth factor 23 N-terminal peptide
- Phosphatonin
- Tumor-derived hypophosphatemia-inducing factor
|
| Gene Name
| FGF23 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in growth factor activity |
| Specific Function
| Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization |
| GO Classification
|
| Function |
| binding |
| protein binding |
| receptor binding |
| growth factor activity |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12p13.3 |
| SNPs
| FGF23 |
| Gene Sequence
|
>756 bp
ATGTTGGGGGCCCGCCTCAGGCTCTGGGTCTGTGCCTTGTGCAGCGTCTGCAGCATGAGC
GTCCTCAGAGCCTATCCCAATGCCTCCCCACTGCTCGGCTCCAGCTGGGGTGGCCTGATC
CACCTGTACACAGCCACAGCCAGGAACAGCTACCACCTGCAGATCCACAAGAATGGCCAT
GTGGATGGCGCACCCCATCAGACCATCTACAGTGCCCTGATGATCAGATCAGAGGATGCT
GGCTTTGTGGTGATTACAGGTGTGATGAGCAGAAGATACCTCTGCATGGATTTCAGAGGC
AACATTTTTGGATCACACTATTTCGACCCGGAGAACTGCAGGTTCCAACACCAGACGCTG
GAAAACGGGTACGACGTCTACCACTCTCCTCAGTATCACTTCCTGGTCAGTCTGGGCCGG
GCGAAGAGAGCCTTCCTGCCAGGCATGAACCCACCCCCGTACTCCCAGTTCCTGTCCCGG
AGGAACGAGATCCCCCTAATTCACTTCAACACCCCCATACCACGGCGGCACACCCGGAGC
GCCGAGGACGACTCGGAGCGGGACCCCCTGAACGTGCTGAAGCCCCGGGCCCGGATGACC
CCGGCCCCGGCCTCCTGTTCACAGGAGCTCCCGAGCGCCGAGGACAACAGCCCGATGGCC
AGTGACCCATTAGGGGTGGTCAGGGGCGGTCGAGTGAACACGCACGCTGGGGGAACGGGC
CCGGAAGGCTGCCGCCCCTTCGCCAAGTTCATCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 251 |
| Molecular Weight
| 27953.6 |
| Theoretical pI
| 9.04 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Fibroblast growth factor 23
MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGH
VDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTL
ENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRS
AEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTG
PEGCRPFAKFI
|
| External Links |
|---|
| GenBank ID Protein
| 10119774 |
| UniProtKB/Swiss-Prot ID
| Q9GZV9 |
| UniProtKB/Swiss-Prot Entry Name
| FGF23_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB037973 |
| GeneCard ID
| FGF23 |
| GenAtlas ID
| FGF23 |
| HGNC ID
| HGNC:3680 |
| References |
|---|
| General References
| Not Available |