| Identification |
|---|
| HMDB Protein ID
| CDBP02070 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histidine-rich glycoprotein |
| Description
| Not Available |
| Synonyms
|
- HPRG
- Histidine-proline-rich glycoprotein
|
| Gene Name
| HRG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cysteine-type endopeptidase inhibitor activity |
| Specific Function
| The physiological function is not yet known. It binds heme, dyes and divalent metal ions. It can inhibit rosette formation and is known to interact with heparin, thrombospondin, and the lysine-binding site of plasminogen. On the basis of its homology with HMW kininogen, the His-rich region of this protein may mediate the contact activation phase of intrinsic blood coagulation cascade |
| GO Classification
|
| Function |
| cysteine-type endopeptidase inhibitor activity |
| peptidase inhibitor activity |
| endopeptidase inhibitor activity |
| enzyme regulator activity |
| enzyme inhibitor activity |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q27 |
| SNPs
| HRG |
| Gene Sequence
|
>1578 bp
ATGAAGGCACTCATTGCAGCACTGCTTTTGATCACATTGCAGTATTCGTGTGCCGTGAGT
CCCACTGACTGCAGTGCTGTTGAGCCGGAGGCTGAGAAAGCTCTAGACCTGATCAATAAA
AGGCGACGGGATGGCTACCTTTTCCAATTGCTGCGGATTGCTGATGCCCACTTGGACAGA
GTGGAAAATACAACTGTATATTACTTAGTCTTAGATGTGCAAGAATCGGACTGTTCGGTC
CTATCCAGGAAATACTGGAATGACTGTGAGCCACCTGATTCCAGACGTCCATCTGAAATA
GTGATCGGACAATGTAAGGTAATAGCTACAAGACATTCCCATGAATCTCAGGACCTCAGA
GTGATTGACTTTAACTGCACCACAAGTTCTGTCTCTTCAGCACTGGCCAATACCAAAGAT
AGTCCGGTCCTCATAGATTTCTTTGAGGATACTGAGCGCTACAGAAAACAAGCCAACAAA
GCCCTTGAGAAGTACAAAGAGGAGAATGATGACTTTGCCTCTTTCAGAGTGGACCGAATC
GAGAGAGTTGCAAGAGTGAGAGGAGGGGAAGGAACTGGTTACTTCGTGGACTTCTCTGTG
CGGAACTGCCCCAGACACCATTTCCCCAGACACCCCAATGTCTTTGGATTCTGCAGAGCA
GATTTGTTCTATGATGTAGAAGCCTTGGACTTGGAAAGCCCGAAAAACCTTGTCATAAAC
TGTGAAGTCTTCGACCCTCAGGAACATGAGAACATCAATGGTGTACCGCCTCATTTGGGA
CATCCCTTCCACTGGGGTGGGCATGAGCGTTCTTCTACCACCAAGCCTCCATTCAAGCCC
CATGGATCTAGAGATCATCATCATCCCCACAAGCCACACGAACATGGACCCCCACCTCCT
CCAGATGAAAGAGATCACTCACATGGACCCCCACTTCCACAAGGCCCTCCTCCACTATTG
CCCATGTCCTGCTCAAGTTGTCAACATGCCACTTTTGGCACAAATGGGGCCCAAAGACAT
TCTCATAATAATAATTCCAGTGACCTCCATCCCCATAAGCATCATTCCCATGAACAGCAT
CCCCACGGACACCATCCCCATGCACACCATCCTCATGAACATGATACCCATAGACAGCAT
CCCCATGGACACCACCCCCATGGACACCATCCTCATGGACACCACCCCCATGGACACCAT
CCCCATGGACACCATCCCCACTGCCATGATTTCCAAGACTATGGACCTTGTGACCCACCA
CCCCATAACCAAGGTCACTGTTGCCATGGCCACGGCCCACCACCTGGGCACTTAAGAAGG
CGAGGCCCAGGTAAAGGACCCCGTCCCTTCCATTGCAGACAAATTGGATCTGTGTACCGA
CTCCCTCCTCTAAGAAAAGGTGAGGTGCTGCCACTTCCTGAGGCCAATTTTCCCAGCTTC
CCATTGCCGCACCACAAACATCCTCTAAAGCCAGACAATCAGCCCTTTCCTCAATCAGTC
TCTGAATCATGTCCAGGGAAGTTCAAGAGTGGGTTTCCACAAGTTTCCATGTTTTTTACA
CATACATTTCCAAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 525 |
| Molecular Weight
| 59578.0 |
| Theoretical pI
| 7.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Histidine-rich glycoprotein
MKALIAALLLITLQYSCAVSPTDCSAVEPEAEKALDLINKRRRDGYLFQLLRIADAHLDR
VENTTVYYLVLDVQESDCSVLSRKYWNDCEPPDSRRPSEIVIGQCKVIATRHSHESQDLR
VIDFNCTTSSVSSALANTKDSPVLIDFFEDTERYRKQANKALEKYKEENDDFASFRVDRI
ERVARVRGGEGTGYFVDFSVRNCPRHHFPRHPNVFGFCRADLFYDVEALDLESPKNLVIN
CEVFDPQEHENINGVPPHLGHPFHWGGHERSSTTKPPFKPHGSRDHHHPHKPHEHGPPPP
PDERDHSHGPPLPQGPPPLLPMSCSSCQHATFGTNGAQRHSHNNNSSDLHPHKHHSHEQH
PHGHHPHAHHPHEHDTHRQHPHGHHPHGHHPHGHHPHGHHPHGHHPHCHDFQDYGPCDPP
PHNQGHCCHGHGPPPGHLRRRGPGKGPRPFHCRQIGSVYRLPPLRKGEVLPLPEANFPSF
PLPHHKHPLKPDNQPFPQSVSESCPGKFKSGFPQVSMFFTHTFPK
|
| External Links |
|---|
| GenBank ID Protein
| 2280514 |
| UniProtKB/Swiss-Prot ID
| P04196 |
| UniProtKB/Swiss-Prot Entry Name
| HRG_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB005803 |
| GeneCard ID
| HRG |
| GenAtlas ID
| HRG |
| HGNC ID
| HGNC:5181 |
| References |
|---|
| General References
| Not Available |