Showing Protein Granzyme B (CDBP02069)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02069
Secondary Accession Numbers Not Available
Name Granzyme B
Description Not Available
Synonyms
  1. C11
  2. CTLA-1
  3. CTSGL1
  4. Cathepsin G-like 1
  5. Cytotoxic T-lymphocyte proteinase 2
  6. Fragmentin-2
  7. Granzyme-2
  8. HLP
  9. Human lymphocyte protein
  10. Lymphocyte protease
  11. SECT
  12. T-cell serine protease 1-3E
Gene Name GZMB
Protein Type Enzyme
Biological Properties
General Function Involved in serine-type endopeptidase activity
Specific Function This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis
GO Classification
Function
endopeptidase activity
serine-type endopeptidase activity
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
Process
proteolysis
metabolic process
macromolecule metabolic process
protein metabolic process
Cellular Location
  1. Cytoplasmic granule
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 14q11.2
SNPs GZMB
Gene Sequence 
>744 bp
ATGCAACCAATCCTGCTTCTGCTGGCCTTCCTCCTGCTGCCCAGGGCAGATGCAGGGGAG
ATCATCGGGGGACATGAGGCCAAGCCCCACTCCCGCCCCTACATGGCTTATCTTATGATC
TGGGATCAGAAGTCTCTGAAGAGGTGCGGTGGCTTCCTGATACAAGACGACTTCGTGCTG
ACAGCTGCTCACTGTTGGGGAAGCTCCATAAATGTCACCTTGGGGGCCCACAATATCAAA
GAACAGGAGCCGACCCAGCAGTTTATCCCTGTGAAAAGACCCATCCCCCATCCAGCCTAT
AATCCTAAGAACTTCTCCAACGACATCATGCTACTGCAGCTGGAGAGAAAGGCCAAGCGG
ACCAGAGCTGTGCAGCCCCTCAGGCTACCTAGCAACAAGGCCCAGGTGAAGCCAGGGCAG
ACATGCAGTGTGGCCGGCTGGGGGCAGACGGCCCCCCTGGGAAAACACTCACACACACTA
CAAGAGGTGAAGATGACAGTGCAGGAAGATCGAAAGTGCGAATCTGACTTACGCCATTAT
TACGACAGTACCATTGAGTTGTGCGTGGGGGACCCAGAGATTAAAAAGACTTCCTTTAAG
GGGGACTCTGGAGGCCCTCTTGTGTGTAACAAGGTGGCCCAGGGCATTGTCTCCTATGGA
CGAAACAATGGCATGCCTCCACGAGCCTGCACCAAAGTCTCAAGCTTTGTACACTGGATA
AAGAAAACCATGAAACGCTACTAA
Protein Properties
Number of Residues 247
Molecular Weight 27688.0
Theoretical pI 10.02
Pfam Domain Function
Signals
  • ["1-18"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Granzyme B
MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIQDDFVL
TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR
TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY
YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI
KKTMKRY
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P10144
UniProtKB/Swiss-Prot Entry Name GRAB_HUMAN
PDB IDs
GenBank Gene ID M17016
GeneCard ID GZMB
GenAtlas ID GZMB
HGNC ID HGNC:4709
References
General References Not Available