| Identification |
|---|
| HMDB Protein ID
| CDBP02061 |
| Secondary Accession Numbers
| Not Available |
| Name
| Proheparin-binding EGF-like growth factor |
| Description
| Not Available |
| Synonyms
|
- DT-R
- Diphtheria toxin receptor
- HB-EGF
- HBEGF
- Heparin-binding EGF-like growth factor
|
| Gene Name
| HBEGF |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in epidermal growth factor receptor binding |
| Specific Function
| May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Single-pass type I membrane protein
- Proheparin-binding EGF-like growth factor:Cell membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q23 |
| SNPs
| HBEGF |
| Gene Sequence
|
>627 bp
ATGAAGCTGCTGCCGTCGGTGGTGCTGAAGCTCTTTCTGGCTGCAGTTCTCTCGGCACTG
GTGACTGGCGAGAGCCTGGAGCGGCTTCGGAGAGGGCTAGCTGCTGGAACCAGCAACCCG
GACCCTCCCACTGTATCCACGGACCAGCTGCTACCCCTAGGAGGCGGCCGGGACCGGAAA
GTCCGTGACTTGCAAGAGGCAGATCTGGACCTTTTGAGAGTCACTTTATCCTCCAAGCCA
CAAGCACTGGCCACACCAAACAAGGAGGAGCACGGGAAAAGAAAGAAGAAAGGCAAGGGG
CTAGGGAAGAAGAGGGACCCATGTCTTCGGAAATACAAGGACTTCTGCATCCATGGAGAA
TGCAAATATGTGAAGGAGCTCCGGGCTCCCTCCTGCATCTGCCACCCGGGTTACCATGGA
GAGAGGTGTCATGGGCTGAGCCTCCCAGTGGAAAATCGCTTATATACCTATGACCACACA
ACCATCCTGGCCGTGGTGGCTGTGGTGCTGTCATCTGTCTGTCTGCTGGTCATCGTGGGG
CTTCTCATGTTTAGGTACCATAGGAGAGGAGGTTATGATGTGGAAAATGAAGAGAAAGTG
AAGTTGGGCATGACTAATTCCCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 208 |
| Molecular Weight
| 23066.8 |
| Theoretical pI
| 9.85 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Proheparin-binding EGF-like growth factor
MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRK
VRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGE
CKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVG
LLMFRYHRRGGYDVENEEKVKLGMTNSH
|
| External Links |
|---|
| GenBank ID Protein
| 3094994 |
| UniProtKB/Swiss-Prot ID
| Q99075 |
| UniProtKB/Swiss-Prot Entry Name
| HBEGF_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AC004634 |
| GeneCard ID
| HBEGF |
| GenAtlas ID
| HBEGF |
| HGNC ID
| HGNC:3059 |
| References |
|---|
| General References
| Not Available |