| Identification |
|---|
| HMDB Protein ID
| CDBP02052 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alpha-methylacyl-CoA racemase |
| Description
| Not Available |
| Synonyms
|
- 2-methylacyl-CoA racemase
|
| Gene Name
| AMACR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
|
| GO Classification
|
| Biological Process |
| bile acid biosynthetic process |
| fatty acid beta-oxidation using acyl-CoA oxidase |
| Cellular Component |
| mitochondrion |
| peroxisomal matrix |
| peroxisome |
| Function |
| catalytic activity |
| Molecular Function |
| catalytic activity |
| alpha-methylacyl-CoA racemase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Mitochondrion
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Primary bile acid biosynthesis | Not Available |  | | Peroxisome | Not Available |  | | Bile Acid Biosynthesis |    | | | Congenital Bile Acid Synthesis Defect Type II |    | Not Available | | Congenital Bile Acid Synthesis Defect Type III |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5p13 |
| SNPs
| AMACR |
| Gene Sequence
|
>1149 bp
ATGGCACTGCAGGGCATCTCGGTCATGGAGCTGTCCGGCCTGGCCCCGGGCCCGTTCTGT
GCTATGGTCCTGGCTGACTTCGGGGCGCGTGTGGTACGCGTGGACCGGCCCGGCTCCCGC
TACGACGTGAGCCGCTTGGGCCGGGGCAAGCGCTCGCTAGTGCTGGACCTGAAGCAGCCG
CGGGGAGCCGCCGTGCTGCGGCGTCTGTGCAAGCGGTCGGATGTGCTGCTGGAGCCCTTC
CGCCGCGGTGTCATGGAGAAACTCCAGCTGGGCCCAGAGATTCTGCAGCGGGAAAATCCA
AGGCTTATTTATGCCAGGCTGAGTGGATTTGGCCAGTCAGGAAGCTTCTGCCGGTTAGCT
GGCCACGATATCAACTATTTGGCTTTGTCAGGTGTTCTCTCAAAAATTGGCAGAAGTGGT
GAGAATCCGTATGCCCCGCTGAATCTCCTGGCTGACTTTGCTGGTGGTGGCCTTATGTGT
GCACTGGGCATTATAATGGCTCTTTTTGACCGCACACGCACTGACAAGGGTCAGGTCATT
GATGCAGATATGGTGGAAGGAACAGCATATTTAAGTTCTTTTCTGTGGAAAACTCAGAAA
TCGAGTCTGTGGGAAGCACCTCGAGGACAGAACATGTTGGATGGTGGAGCACCTTTCTAT
ACGACTTACAGGACAGCAGATGGGGAATTCATGGCTGTTGGAGCAATAGAACCCCAGTTC
TACGAGCTGCTGATCAAAGGACTTGGACTAAAGTCTGATGAACTTCCCTCTCAGATGAGC
ACGGATGATTGGCCAGAAATGAAGAAGAAGTTTGCAGATGTATTTGCAAAGAAGACGAAG
GCAGAGTGGTGTCAAATCTTTGACGGCACAGATGCCTGTGTGACTCCGGTTCTGACTTTT
GAGGAGGTTGTTCATCATGATCACAACAAGGAACGGGGCTCGTTTATCACCAGTGAGGAG
CAGGACGTGAGCCCCCGCCCTGCACCTCTGCTGTTAAACACCCCAGCCATCCCTTCTTTC
AAAAGGGATCCTTTCATAGGAGAACACACTGAGGAGATACTTGAAGAATTTGGATTCAGC
CGCGAAGAGATTTATCAGCTTAACTCAGATAAAATCATTGAAAGTAATAAGGTAAAAGCT
AGTCTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 382 |
| Molecular Weight
| 43859.945 |
| Theoretical pI
| 6.8 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alpha-methylacyl-CoA racemase
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQP
RGAAVLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLA
GHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKSSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQF
YELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAKKTKAEWCQIFDGTDACVTPVLTF
EEVVHHDHNKERGSFITSEEQDVSPRPAPLLLNTPAIPSFKRDPFIGEHTEEILEEFGFS
REEIYQLNSDKIIESNKVKASL
|
| External Links |
|---|
| GenBank ID Protein
| 4204097 |
| UniProtKB/Swiss-Prot ID
| Q9UHK6 |
| UniProtKB/Swiss-Prot Entry Name
| AMACR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF047020 |
| GeneCard ID
| AMACR |
| GenAtlas ID
| AMACR |
| HGNC ID
| HGNC:451 |
| References |
|---|
| General References
| Not Available |