<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <id type="integer">2041</id>
  <cancdbp-id>CDBP02040</cancdbp-id>
  <name>Fatty acid desaturase 1</name>
  <uniprot-id>O60427</uniprot-id>
  <uniprot-name>FADS1_HUMAN</uniprot-name>
  <enzyme type="boolean">true</enzyme>
  <transporter type="boolean">false</transporter>
  <protein-type>Enzyme</protein-type>
  <organism>Homo_sapiens</organism>
  <gene-name>FADS1</gene-name>
  <num-residues type="integer">444</num-residues>
  <molecular-weight type="decimal">51963.9</molecular-weight>
  <theoretical-pi type="decimal">9.15</theoretical-pi>
  <general-function>Involved in heme binding</general-function>
  <specific-function>Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively</specific-function>
  <signal-regions type="array">
    <signal-region>["None"]</signal-region>
  </signal-regions>
  <transmembrane-regions type="array">
    <transmembrane-region>["122-142", "146-170", "268-288", "306-326"]</transmembrane-region>
  </transmembrane-regions>
  <pdb-ids nil="true"/>
  <genbank-gene-id>AC004770</genbank-gene-id>
  <genbank-protein-id>3169158</genbank-protein-id>
  <genecard-id>FADS1</genecard-id>
  <chromosome-location>Chromosome:1</chromosome-location>
  <locus>11q12.2-q13.1</locus>
  <geneatlas-id>FADS1</geneatlas-id>
  <hgnc-id>HGNC:3574</hgnc-id>
  <export type="boolean">true</export>
  <comment nil="true"/>
  <kegg-id nil="true"/>
  <meta-cyc-id nil="true"/>
  <ncbi-sequence-ids nil="true"/>
  <tissue-specificity nil="true"/>
  <cofactor nil="true"/>
  <subunit nil="true"/>
  <cellular-location nil="true"/>
  <ec-number nil="true"/>
  <created-at type="dateTime">2020-06-12T23:07:01Z</created-at>
  <updated-at type="dateTime">2020-07-28T02:27:27Z</updated-at>
  <description nil="true"/>
  <receptor type="integer">0</receptor>
  <metal-binding type="integer">1</metal-binding>
  <trans-factor type="integer">0</trans-factor>
</protein>

