Showing Protein Mannose-binding protein C (CDBP02039)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP02039
Secondary Accession Numbers Not Available
Name Mannose-binding protein C
Description Not Available
Synonyms
  1. Collectin-1
  2. MBP-C
  3. MBP1
  4. Mannan-binding protein
  5. Mannose-binding lectin
Gene Name MBL2
Protein Type Enzyme
Biological Properties
General Function Involved in binding
Specific Function Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA
GO Classification
Function
binding
Cellular Location
  1. Secreted
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 10q11.2
SNPs MBL2
Gene Sequence 
>747 bp
ATGTCCCTGTTTCCATCACTCCCTCTCCTTCTCCTGAGTATGGTGGCAGCGTCTTACTCA
GAAACTGTGACCTGTGAGGATGCCCAAAAGACCTGCCCTGCAGTGATTGCCTGTAGCTCT
CCAGGCATCAACGGCTTCCCAGGCAAAGATGGGCGTGATGGCACCAAGGGAGAAAAGGGG
GAACCAGGCCAAGGGCTCAGAGGCTTACAGGGCCCCCCTGGAAAGTTGGGGCCTCCAGGA
AATCCAGGGCCTTCTGGGTCACCAGGACCAAAGGGCCAAAAAGGAGACCCTGGAAAAAGT
CCGGATGGTGATAGTAGCCTGGCTGCCTCAGAAAGAAAAGCTCTGCAAACAGAAATGGCA
CGTATCAAAAAGTGGCTGACCTTCTCTCTGGGCAAACAAGTTGGGAACAAGTTCTTCCTG
ACCAATGGTGAAATAATGACCTTTGAAAAAGTGAAGGCCTTGTGTGTCAAGTTCCAGGCC
TCTGTGGCCACCCCCAGGAATGCTGCAGAGAATGGAGCCATTCAGAATCTCATCAAGGAG
GAAGCCTTCCTGGGCATCACTGATGAGAAGACAGAAGGGCAGTTTGTGGATCTGACAGGA
AATAGACTGACCTACACAAACTGGAACGAGGGTGAACCCAACAATGCTGGTTCTGATGAA
GATTGTGTATTGCTACTGAAAAATGGCCAGTGGAATGACGTCCCCTGCTCCACCTCCCAT
CTGGCCGTCTGTGAGTTCCCTATCTGA
Protein Properties
Number of Residues 248
Molecular Weight 26143.3
Theoretical pI 5.14
Pfam Domain Function
Signals
  • ["1-20"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Mannose-binding protein C
MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKG
EPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMA
RIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKE
EAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSH
LAVCEFPI
GenBank ID Protein 34487
UniProtKB/Swiss-Prot ID P11226
UniProtKB/Swiss-Prot Entry Name MBL2_HUMAN
PDB IDs
GenBank Gene ID X15422
GeneCard ID MBL2
GenAtlas ID MBL2
HGNC ID HGNC:6922
References
General References Not Available