Cannabis Compound Database: Showing Protein Nuclear receptor ROR-alpha (CDBP02007)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02007

Secondary Accession Numbers

Not Available

Name

Nuclear receptor ROR-alpha

Description

Not Available

Synonyms

Nuclear receptor RZR-alpha
Nuclear receptor subfamily 1 group F member 1
Retinoid-related orphan receptor-alpha

Gene Name

RORA

Protein Type

Enzyme

Biological Properties

General Function

Involved in sequence-specific DNA binding transcription factor activity

Specific Function

Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives

GO Classification

Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
molecular transducer activity
signal transducer activity
nucleic acid binding
dna binding
sequence-specific dna binding
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
sequence-specific dna binding transcription factor activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
receptor activity
Process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent

Cellular Location

Nucleus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

15q22.2

SNPs

RORA

Gene Sequence

>1671 bp
ATGAATGAGGGGGCCCCAGGAGACAGTGACTTAGAGACTGAGGCAAGAGTGCCGTGGTCA
ATCATGGGTCATTGTCTTCGAACTGGACAGGCCAGAATGTCTGCCACACCCACACCTGCA
GGTGAAGGAGCCAGAAGGGATGAACTTTTTGGGATTCTCCAAATACTCCATCAGTGTATC
CTGTCTTCAGGTGATGCTTTTGTTCTTACTGGCGTCTGTTGTTCCTGGAGGCAGAATGGC
AAGCCACCATATTCACAAAAGGAAGATAAGGAAGTACAAACTGGATACATGAATGCTCAA
ATTGAAATTATTCCATGCAAGATCTGTGGAGACAAATCATCAGGAATCCATTATGGTGTC
ATTACATGTGAAGGCTGCAAGGGCTTTTTCAGGAGAAGTCAGCAAAGCAATGCCACCTAC
TCCTGTCCTCGTCAGAAGAACTGTTTGATTGATCGAACCAGTAGAAACCGCTGCCAACAC
TGTCGATTACAGAAATGCCTTGCCGTAGGGATGTCTCGAGATGCTGTAAAATTTGGCCGA
ATGTCAAAAAAGCAGAGAGACAGCTTGTATGCAGAAGTACAGAAACACCGGATGCAGCAG
CAGCAGCGCGACCACCAGCAGCAGCCTGGAGAGGCTGAGCCGCTGACGCCCACCTACAAC
ATCTCGGCCAACGGGCTGACGGAACTTCACGACGACCTCAGTAACTACATTGACGGGCAC
ACCCCTGAGGGGAGTAAGGCAGACTCCGCCGTCAGCAGCTTCTACCTGGACATACAGCCT
TCCCCAGACCAGTCAGGTCTTGATATCAATGGAATCAAACCAGAACCAATATGTGACTAC
ACACCAGCATCAGGCTTCTTTCCCTACTGTTCGTTCACCAACGGCGAGACTTCCCCAACT
GTGTCCATGGCAGAATTAGAACACCTTGCACAGAATATATCTAAATCGCATCTGGAAACC
TGCCAATACTTGAGAGAAGAGCTCCAGCAGATAACGTGGCAGACCTTTTTACAGGAAGAA
ATTGAGAACTATCAAAACAAGCAGCGGGAGGTGATGTGGCAATTGTGTGCCATCAAAATT
ACAGAAGCTATACAGTATGTGGTGGAGTTTGCCAAACGCATTGATGGATTTATGGAACTG
TGTCAAAATGATCAAATTGTGCTTCTAAAAGCAGGTTCTCTAGAGGTGGTGTTTATCAGA
ATGTGCCGTGCCTTTGACTCTCAGAACAACACCGTGTACTTTGATGGGAAGTATGCCAGC
CCCGACGTCTTCAAATCCTTAGGTTGTGAAGACTTTATTAGCTTTGTGTTTGAATTTGGA
AAGAGTTTATGTTCTATGCACCTGACTGAAGATGAAATTGCATTATTTTCTGCATTTGTA
CTGATGTCAGCAGATCGCTCATGGCTGCAAGAAAAGGTAAAAATTGAAAAACTGCAACAG
AAAATTCAGCTAGCTCTTCAACACGTCCTACAGAAGAATCACCGAGAAGATGGAATACTA
ACAAAGTTAATATGCAAGGTGTCTACATTAAGAGCCTTATGTGGACGACATACAGAAAAG
CTAATGGCATTTAAAGCAATATACCCAGACATTGTGCGACTTCATTTTCCTCCATTATAC
AAGGAGTTGTTCACTTCAGAATTTGAGCCAGCAATGCAAATTGATGGGTAA

Protein Properties

Number of Residues

556

Molecular Weight

63035.2

Theoretical pI

6.34

Pfam Domain Function

Hormone_recep (PF00104 )
zf-C4 (PF00105 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Nuclear receptor ROR-alpha
MNEGAPGDSDLETEARVPWSIMGHCLRTGQARMSATPTPAGEGARRDELFGILQILHQCI
LSSGDAFVLTGVCCSWRQNGKPPYSQKEDKEVQTGYMNAQIEIIPCKICGDKSSGIHYGV
ITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGR
MSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGH
TPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPT
VSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKI
TEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYAS
PDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQ
KIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLY
KELFTSEFEPAMQIDG

External Links

GenBank ID Protein

19743901

UniProtKB/Swiss-Prot ID

P35398

UniProtKB/Swiss-Prot Entry Name

RORA_HUMAN

PDB IDs