| Identification |
|---|
| HMDB Protein ID
| CDBP02004 |
| Secondary Accession Numbers
| Not Available |
| Name
| Aquaporin-3 |
| Description
| Not Available |
| Synonyms
|
- AQP-3
- Aquaglyceroporin-3
|
| Gene Name
| AQP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism |
| GO Classification
|
| Component |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transporter activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
|
| Cellular Location
|
- Multi-pass membrane protein
- Basolateral cell membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Kidney Function |    | Not Available | | Glucose Transporter Defect (SGLT2) |    | Not Available | | Hartnup Disorder |    | Not Available | | Iminoglycinuria |    | Not Available | | Lysinuric Protein Intolerance |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9p13 |
| SNPs
| AQP3 |
| Gene Sequence
|
>879 bp
ATGGGTCGACAGAAGGAGCTGGTGTCCCGCTGCGGGGAGATGCTCCACATCCGCTACCGG
TTGCTCCGACAGGCGCTGGCCGAGTGCCTGGGGACCCTCATCCTCGTGATGTTTGGCTGT
GGCTCCGTGGCCCAGGTTGTGCTCAGCCGGGGCACCCACGGTGGTTTCCTCACCATCAAC
CTGGCCTTTGGCTTTGCTGTCACTCTGGGCATCCTCATCGCTGGCCAGGTCTCTGGGGCC
CACCTGAACCCTGCCGTGACCTTTGCCATGTGCTTCCTGGCTCGTGAGCCCTGGATCAAG
CTGCCCATCTACACCCTGGCACAGACGCTGGGAGCCTTCTTGGGTGCTGGAATAGTTTTT
GGGCTGTATTATGATGCAATCTGGCACTTTGCCGACAACCAGCTTTTTGTTTCGGGCCCC
AATGGCACAGCCGGCATCTTTGCTACCTACCCCTCTGGACACTTGGATATGATCAATGGC
TTCTTTGACCAGTTCATAGGCACAGCCTCCCTTATCGTGTGTGTGCTGGCCATTGTTGAC
CCTTACAACAACCCCGTCCCCCGAGGCCTGGAGGCCTTCACCGTGGGCCTGGTGGTCCTG
GTCATTGGCACCTCCATGGGCTTCAACTCCGGCTATGCCGTCAACCCTGCCCGGGACTTT
GGCCCCCGCCTTTTTACAGCCCTTGCGGGCTGGGGCTCTGCAGTCTTCACGACCGGCCAG
CATTGGTGGTGGGTGCCCATCGTGTCCCCACTCCTGGGCTCCATTGCGGGTGTCTTCGTG
TACCAGCTGATGATCGGCTGCCACCTGGAGCAGCCCCCACCCTCCAACGAGGAAGAGAAT
GTGAAGCTGGCCCATGTGAAGCACAAGGAGCAGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 292 |
| Molecular Weight
| 31543.6 |
| Theoretical pI
| 7.25 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["29-49", "54-74", "110-130", "158-178", "189-209", "245-265"]
|
| Protein Sequence
|
>Aquaporin-3
MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTIN
LAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVF
GLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVD
PYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQ
HWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI
|
| External Links |
|---|
| GenBank ID Protein
| 1854374 |
| UniProtKB/Swiss-Prot ID
| Q92482 |
| UniProtKB/Swiss-Prot Entry Name
| AQP3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB001325 |
| GeneCard ID
| AQP3 |
| GenAtlas ID
| AQP3 |
| HGNC ID
| HGNC:636 |
| References |
|---|
| General References
| Not Available |