| Identification |
|---|
| HMDB Protein ID
| CDBP02003 |
| Secondary Accession Numbers
| Not Available |
| Name
| Leptin |
| Description
| Not Available |
| Synonyms
|
- Obese protein
- Obesity factor
|
| Gene Name
| LEP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hormone activity |
| Specific Function
| May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| hormone activity |
| binding |
| protein binding |
| receptor binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q31.3 |
| SNPs
| LEP |
| Gene Sequence
|
>504 bp
ATGCATTGGGGAACCCTGTGCGGATTCTTGTGGCTTTGGCCCTATCTTTTCTATGTCCAA
GCTGTGCCCATCCAAAAAGTCCAAGATGACACCAAAACCCTCATCAAGACAATTGTCACC
AGGATCAATGACATTTCACACACGCAGTCAGTCTCCTCCAAACAGAAAGTCACCGGTTTG
GACTTCATTCCTGGGCTCCACCCCATCCTGACCTTATCCAAGATGGACCAGACACTGGCA
GTCTACCAACAGATCCTCACCAGTATGCCTTCCAGAAACGTGATCCAAATATCCAACGAC
CTGGAGAACCTCCGGGATCTTCTTCACGTGCTGGCCTTCTCTAAGAGCTGCCACTTGCCC
TGGGCCAGTGGCCTGGAGACCTTGGACAGCCTGGGGGGTGTCCTGGAAGCTTCAGGCTAC
TCCACAGAGGTGGTGGCCCTGAGCAGGCTGCAGGGGTCTCTGCAGGACATGCTGTGGCAG
CTGGACCTCAGCCCTGGGTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 167 |
| Molecular Weight
| 18640.4 |
| Theoretical pI
| 6.34 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Leptin
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGL
DFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLP
WASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P41159 |
| UniProtKB/Swiss-Prot Entry Name
| LEP_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U18915 |
| GeneCard ID
| LEP |
| GenAtlas ID
| LEP |
| HGNC ID
| HGNC:6553 |
| References |
|---|
| General References
| Not Available |