Identification |
HMDB Protein ID
| CDBP01985 |
Secondary Accession Numbers
| Not Available |
Name
| Sodium/bile acid cotransporter |
Description
| Not Available |
Synonyms
|
- Cell growth-inhibiting gene 29 protein
- Na(+)/bile acid cotransporter
- Na(+)/taurocholate transport protein
- Sodium/taurocholate cotransporting polypeptide
- Solute carrier family 10 member 1
|
Gene Name
| SLC10A1 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in bile acid:sodium symporter activity |
Specific Function
| The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
|
GO Classification
|
Biological Process |
bile acid metabolic process |
Cellular Component |
basolateral plasma membrane |
integral to plasma membrane |
Component |
membrane |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
substrate-specific transmembrane transporter activity |
organic acid:sodium symporter activity |
transporter activity |
bile acid:sodium symporter activity |
organic acid transmembrane transporter activity |
transmembrane transporter activity |
Molecular Function |
bile acid:sodium symporter activity |
Process |
sodium ion transport |
establishment of localization |
transport |
organic anion transport |
anion transport |
monovalent inorganic cation transport |
ion transport |
cation transport |
|
Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Bile secretion | Not Available | |
|
Gene Properties |
Chromosome Location
| 14 |
Locus
| 14q24.1 |
SNPs
| SLC10A1 |
Gene Sequence
|
>1050 bp
ATGGAGGCCCACAACGCGTCTGCCCCATTCAACTTCACCCTGCCACCCAACTTTGGCAAG
CGCCCCACAGACCTGGCACTGAGCGTCATCCTGGTGTTCATGTTGTTCTTCATCATGCTC
TCGCTGGGCTGCACCATGGAGTTCAGCAAGATCAAGGCTCACTTATGGAAGCCTAAAGGG
CTGGCCATCGCCCTGGTGGCACAGTATGGCATCATGCCCCTCACGGCCTTTGTGCTGGGC
AAGGTCTTCCGGCTGAAGAACATTGAGGCACTGGCCATCTTGGTCTGTGGCTGCTCACCT
GGAGGGAACCTGTCCAATGTCTTCAGTCTGGCCATGAAGGGGGACATGAACCTCAGCATT
GTGATGACCACCTGCTCCACCTTCTGTGCCCTTGGCATGATGCCTCTCCTCCTGTACATC
TACTCCAGGGGGATCTATGATGGGGACCTGAAGGACAAGGTGCCCTATAAAGGCATCGTG
ATATCACTGGTCCTGGTTCTCATTCCTTGCACCATAGGGATCGTCCTCAAATCCAAACGG
CCACAATACATGCGCTATGTCATCAAGGGAGGGATGATCATCATTCTCTTGTGCAGTGTG
GCCGTCACAGTTCTCTCTGCCATCAATGTGGGGAAGAGCATCATGTTTGCCATGACACCA
CTCTTGATTGCCACCTCCTCCCTGATGCCTTTTATTGGCTTTCTGCTGGGTTATGTTCTC
TCTGCTCTCTTCTGCCTCAATGGACGGTGCAGACGCACTGTCAGCATGGAGACTGGATGC
CAAAATGTCCAACTCTGTTCCACCATCCTCAATGTGGCCTTTCCACCTGAAGTCATTGGA
CCACTTTTCTTCTTTCCCCTCCTCTACATGATTTTCCAGCTTGGAGAAGGGCTTCTCCTC
ATTGCCATATTTTGGTGCTATGAGAAATTCAAGACTCCCAAGGATAAAACAAAAATGATC
TACACAGCTGCCACAACTGAAGAAACAATTCCAGGAGCTCTGGGAAATGGCACCTACAAA
GGGGAGGACTGCTCCCCTTGCACAGCCTAG
|
Protein Properties |
Number of Residues
| 349 |
Molecular Weight
| 38118.64 |
Theoretical pI
| 8.788 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Sodium/bile acid cotransporter
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSI
VMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKR
PQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVL
SALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q14973 |
UniProtKB/Swiss-Prot Entry Name
| NTCP_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| L21893 |
GeneCard ID
| SLC10A1 |
GenAtlas ID
| SLC10A1 |
HGNC ID
| HGNC:10905 |
References |
General References
| Not Available |