| Identification |
|---|
| HMDB Protein ID
| CDBP01973 |
| Secondary Accession Numbers
| Not Available |
| Name
| Urea transporter 2 |
| Description
| Not Available |
| Synonyms
|
- Solute carrier family 14 member 2
- Urea transporter, kidney
|
| Gene Name
| SLC14A2 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in urea transmembrane transporter activity |
| Specific Function
| Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.
|
| GO Classification
|
| Biological Process |
| ammonium transmembrane transport |
| Cellular Component |
| plasma membrane |
| apical plasma membrane |
| integral to membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| substrate-specific transmembrane transporter activity |
| transporter activity |
| amide transmembrane transporter activity |
| urea transmembrane transporter activity |
| transmembrane transporter activity |
| Molecular Function |
| urea transmembrane transporter activity |
| ammonium transmembrane transporter activity |
| Process |
| amide transport |
| urea transport |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Multi-pass membrane protein
- Apical cell membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Kidney Function |    | Not Available | | Glucose Transporter Defect (SGLT2) |    | Not Available | | Hartnup Disorder |    | Not Available | | Iminoglycinuria |    | Not Available | | Lysinuric Protein Intolerance |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18q12.1-q21.1 |
| SNPs
| SLC14A2 |
| Gene Sequence
|
>2763 bp
ATGTCTGACCCCCACAGCAGTCCTCTCCTGCCAGAGCCACTTTCCAGCAGATACAAACTC
TACGAGGCAGAGTTTACCAGCCCGAGCTGGCCCTCGACATCCCCGGATACTCACCCAGCT
CTGCCCCTCCTGGAAATGCCTGAAGAAAAGGATCTCCGGTCTTCCAATGAAGACAGTCAC
ATTGTGAAGATCGAAAAGCTCAATGAAAGGAGTAAAAGGAAAGACGACGGGGTGGCCCAT
CGGGACTCAGCAGGCCAAAGGTGCATCTGCCTCTCCAAAGCAGTGGGCTACCTCACGGGC
GACATGAAGGAGTACAGGATCTGGCTGAAAGACAAGCACCTTGCCCTCCAGTTCATAGAC
TGGGTCCTGAGAGGGACCGCTCAGGTGATGTTCATCAACAATCCTCTCAGCGGCCTCATC
ATCTTCATAGGGCTGCTGATCCAGAATCCCTGGTGGACAATCACTGGGGGCCTGGGGACA
GTGGTCTCGACCTTAACAGCTCTCGCCTTGGGCCAAGACAGGTCTGCCATTGCCTCAGGA
CTCCATGGGTACAACGGGATGCTGGTGGGACTGCTGATGGCCGTGTTCTCGGAGAAGTTA
GACTACTACTGGTGGCTTCTGTTTCCTGTGACCTTCACAGCCATGTCCTGCCCAGTTCTT
TCTAGTGCCTTGAATTCCATCTTCAGCAAGTGGGACCTCCCGGTCTTCACTCTGCCCTTC
AACATTGCAGTCACCTTGTACCTTGCAGCCACAGGCCACTACAACCTCTTCTTCCCCACA
ACACTGGTAGAGCCTGTGTCTTCAGTGCCCAATATCACCTGGACAGAGATGGAAATGCCC
CTGCTGTTACAAGCCATCCCTGTTGGGGTCGGCCAGGTGTATGGCTGTGACAATCCCTGG
ACAGGCGGCGTGTTCCTGGTGGCTCTGTTCATCTCCTCGCCACTCATCTGCTTGCATGCA
GCCATTGGCTCAATCGTGGGGCTGCTAGCAGCCCTGTCAGTGGCCACACCCTTCGAGACC
ATCTACACAGGCCTCTGGAGCTACAACTGCGTCCTCTCCTGCATCGCCATCGGAGGCATG
TTCTATGCCCTCACCTGGCAGACTCACCTGCTGGCCCTCATCTGTGCCCTGTTCTGTGCA
TACATGGAAGCAGCCATCTCCAACATCATGTCAGTGGTGGGCGTGCCACCAGGCACCTGG
GCCTTCTGCCTTGCCACCATCATCTTCCTGCTCCTGACGACAAACAACCCAGCCATCTTC
AGACTCCCACTCAGCAAAGTCACCTACCCCGAGGCCAACCGCATCTACTACCTGACAGTG
AAAAGCGGTGAAGAAGAGAAGGCCCCCAGCGGAGGCGGTGGGGAGCATCCACCCACAGCA
GGCCCAAAGGTGGAGGAGGGCTCGGAGGCTGTGCTCTCCAAGCACAGGAGTGTATTTCAC
ATCGAGTGGTCATCCATTCGGAGGAGGAGCAAAGTGTTTGGAAAAGGCGAACACCAGGAA
AGACAAAACAAAGACCCATTTCCCTATCGATACCGGAAGCCCACAGTCGAGCTGCTTGAT
CTGGACACCATGGAGGAGAGCTCTGAGATAAAAGTGGAAACAAACATTTCCAAGACATCC
TGGATTCGGAGTTCCATGGCTGCCAGTGGGAAAAGGGTCAGCAAAGCCCTCAGCTACATC
ACAGGAGAGATGAAGGAGTGTGGAGAGGGACTTAAAGACAAGTCCCCAGTGTTCCAGTTC
TTTGACTGGGTCCTCCGAGGCACATCTCAAGTGATGTTTGTGAACAACCCCCTCAGCGGC
ATCCTCATCATCCTCGGCCTCTTCATCCAGAACCCCTGGTGGGCGATCTCAGGCTGCCTG
GGTACCATCATGTCCACCTTGACAGCCCTCATCCTGAGTCAGGACAAGTCGGCCATCGCT
GCAGGATTTCACGGCTACAATGGGGTGCTGGTGGGGCTGCTGATGGCCGTGTTCTCAGAC
AAAGGTGACTACTACTGGTGGCTGTTGCTACCCGTCATCATCATGTCCATGTCTTGCCCC
ATCCTCTCCAGTGCCCTGGGTACCATCTTCAGCAAGTGGGACCTCCCAGTCTTCACACTG
CCCTTCAATATCACTGTGACTTTGTACCTGGCAGCCACGGGCCACTACAACCTTTTCTTC
CCCACAACGCTGCTGCAGCCTGCATCCGCCATGCCCAACATCACCTGGTCAGAGGTCCAA
GTGCCCTTGCTTTTGAGAGCCATCCCCGTTGGAATTGGCCAAGTGTACGGCTGTGATAAC
CCCTGGACTGGAGGCATCTTCCTCATAGCTCTGTTCATATCCTCACCTCTCATTTGCTTG
CATGCAGCAATTGGATCCACCATGGGGATGCTAGCAGCACTCACTATTGCGACGCCCTTT
GACTCCATCTACTTCGGCCTGTGTGGCTTCAACAGCACCCTCGCATGCATAGCGATAGGA
GGCATGTTCTACGTCATCACCTGGCAGACGCACCTCCTCGCCATCGCCTGCGCACTGTTT
GCTGCCTACCTGGGTGCTGCCCTGGCTAACATGTTATCTGTGTTTGGATTGCCGCCCTGC
ACTTGGCCCTTCTGTCTCTCAGCTCTCACCTTCCTGCTCCTGACGACCAATAACCCCGCC
ATCTACAAGCTCCCGCTCAGCAAAGTCACCTACCCAGAGGCCAACCGCATCTACTACCTG
TCCCAGGAGAGAAACAGAAGGGCATCAATCATAACAAAGTATCAGGCCTACGATGTCTCC
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 920 |
| Molecular Weight
| 101207.965 |
| Theoretical pI
| 6.944 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Urea transporter 2
MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSH
IVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFID
WVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASG
LHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPF
NIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPW
TGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGM
FYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIF
RLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFH
IEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTS
WIRSSMAASGKRVSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSG
ILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSD
KGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFF
PTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICL
HAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALF
AAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYL
SQERNRRASIITKYQAYDVS
|
| External Links |
|---|
| GenBank ID Protein
| 157694503 |
| UniProtKB/Swiss-Prot ID
| Q15849 |
| UniProtKB/Swiss-Prot Entry Name
| UT2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_007163.3 |
| GeneCard ID
| SLC14A2 |
| GenAtlas ID
| SLC14A2 |
| HGNC ID
| HGNC:10919 |
| References |
|---|
| General References
| Not Available |