Showing Protein Hepcidin (CDBP01967)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP01967
Secondary Accession Numbers Not Available
Name Hepcidin
Description Not Available
Synonyms
  1. Hepc20
  2. Hepc25
  3. Hepcidin-20
  4. Hepcidin-25
  5. LEAP-1
  6. Liver-expressed antimicrobial peptide 1
  7. PLTR
  8. Putative liver tumor regressor
Gene Name HAMP
Protein Type Enzyme
Biological Properties
General Function Involved in cellular iron ion homeostasis
Specific Function Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa
GO Classification
Component
extracellular region
Process
cellular iron ion homeostasis
biological regulation
regulation of biological quality
homeostatic process
chemical homeostasis
ion homeostasis
cellular ion homeostasis
cellular cation homeostasis
cellular di-, tri-valent inorganic cation homeostasis
Cellular Location
  1. Secreted
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19q13.1
SNPs HAMP
Gene Sequence 
>255 bp
ATGGCACTGAGCTCCCAGATCTGGGCCGCTTGCCTCCTGCTCCTCCTCCTCCTCGCCAGC
CTGACCAGTGGCTCTGTTTTCCCACAACAGACGGGACAACTTGCAGAGCTGCAACCCCAG
GACAGAGCTGGAGCCAGGGCCAGCTGGATGCCCATGTTCCAGAGGCGAAGGAGGCGAGAC
ACCCACTTCCCCATCTGCATTTTCTGCTGCGGCTGCTGTCATCGATCAAAGTGTGGGATG
TGCTGCAAGACGTAG
Protein Properties
Number of Residues 84
Molecular Weight 9408.1
Theoretical pI 8.88
Pfam Domain Function
Signals
  • ["1-24"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Hepcidin
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRD
THFPICIFCCGCCHRSKCGMCCKT
GenBank ID Protein 10863973
UniProtKB/Swiss-Prot ID P81172
UniProtKB/Swiss-Prot Entry Name HEPC_HUMAN
PDB IDs
GenBank Gene ID NM_021175.2
GeneCard ID HAMP
GenAtlas ID HAMP
HGNC ID HGNC:15598
References
General References Not Available