| Identification |
|---|
| HMDB Protein ID
| CDBP01965 |
| Secondary Accession Numbers
| Not Available |
| Name
| Bile acid receptor |
| Description
| Not Available |
| Synonyms
|
- Farnesoid X-activated receptor
- Farnesol receptor HRR-1
- Nuclear receptor subfamily 1 group H member 4
- RXR-interacting protein 14
- Retinoid X receptor-interacting protein 14
|
| Gene Name
| NR1H4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding transcription factor activity |
| Specific Function
| Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus |
| GO Classification
|
| Component |
| intracellular membrane-bounded organelle |
| nucleus |
| organelle |
| membrane-bounded organelle |
| Function |
| sequence-specific dna binding transcription factor activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| receptor activity |
| molecular transducer activity |
| signal transducer activity |
| nucleic acid binding |
| dna binding |
| sequence-specific dna binding |
| ligand-dependent nuclear receptor activity |
| steroid hormone receptor activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
|
| Cellular Location
|
- Nucleus (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q23.1 |
| SNPs
| NR1H4 |
| Gene Sequence
|
>1461 bp
ATGGTAATGCAGTTTCAGGGGTTAGAAAATCCAATTCAAATTAGTCCTCACTGCAGCTGT
ACGCCGTCAGGATTTTTCATGGAAATGATGAGTATGAAGCCCGCGAAAGGTGTTTTAACA
GAACAAGTGGCAGGTCCTCTGGGACAGAACCTGGAAGTGGAACCATACTCGCAATACAGC
AATGTTCAGTTTCCCCAAGTTCAACCACAGATTTCCTCGTCATCCTATTATTCCAACCTG
GGTTTCTACCCCCAGCAGCCTGAAGAGTGGTACTCTCCTGGAATATATGAACTCAGGCGT
ATGCCAGCTGAGACTCTCTACCAGGGAGAAACTGAGGTAGCAGAGATGCCTGTAACAAAG
AAGCCCCGCATGGGCGCGTCAGCAGGGAGGATCAAAGGGGATGAGCTGTGTGTTGTTTGT
GGAGACAGAGCCTCTGGATACCACTATAATGCACTGACCTGTGAGGGGTGTAAAGGTTTC
TTCAGGAGAAGCATTACCAAAAACGCTGTGTACAAGTGTAAAAACGGGGGCAACTGTGTG
ATGGATATGTACATGCGAAGAAAGTGTCAAGAGTGTCGACTAAGGAAATGCAAAGAGATG
GGAATGTTGGCTGAATGTATGTATACAGGCTTGTTAACTGAAATTCAGTGTAAATCTAAG
CGACTGAGAAAAAATGTGAAGCAGCATGCAGATCAGACCGTGAATGAAGACAGTGAAGGT
CGTGACTTGCGACAAGTGACCTCGACAACAAAGTCATGCAGGGAGAAAACTGAACTCACC
CCAGATCAACAGACTCTTCTACATTTTATTATGGATTCATATAACAAACAGAGGATGCCT
CAGGAAATAACAAATAAAATTTTAAAAGAAGAATTCAGTGCAGAAGAAAATTTTCTCATT
TTGACGGAAATGGCAACCAATCATGTACAGGTTCTTGTAGAATTCACAAAAAAGCTACCA
GGATTTCAGACTTTGGACCATGAAGACCAGATTGCTTTGCTGAAAGGGTCTGCGGTTGAA
GCTATGTTCCTTCGTTCAGCTGAGATTTTCAATAAGAAACTTCCGTCTGGGCATTCTGAC
CTATTGGAAGAAAGAATTCGAAATAGTGGTATCTCTGATGAATATATAACACCTATGTTT
AGTTTTTATAAAAGTATTGGGGAACTGAAAATGACTCAAGAGGAGTATGCTCTGCTTACA
GCAATTGTTATCCTGTCTCCAGATAGACAATACATAAAGGATAGAGAGGCAGTAGAGAAG
CTTCAGGAGCCACTTCTTGATGTGCTACAAAAGTTGTGTAAGATTCACCAGCCTGAAAAT
CCTCAACACTTTGCCTGTCTCCTGGGTCGCCTGACTGAATTACGGACATTCAATCATCAC
CACGCTGAGATGCTGATGTCATGGAGAGTAAACGACCACAAGTTTACCCCACTTCTCTGT
GAAATCTGGGACGTGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 486 |
| Molecular Weight
| 55913.9 |
| Theoretical pI
| 6.81 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Bile acid receptor
MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
|
| External Links |
|---|
| GenBank ID Protein
| 21434818 |
| UniProtKB/Swiss-Prot ID
| Q96RI1 |
| UniProtKB/Swiss-Prot Entry Name
| NR1H4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF478446 |
| GeneCard ID
| NR1H4 |
| GenAtlas ID
| NR1H4 |
| HGNC ID
| HGNC:7967 |
| References |
|---|
| General References
| Not Available |