| Identification |
|---|
| HMDB Protein ID
| CDBP01962 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peroxiredoxin-5, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- AOEB166
- Alu corepressor 1
- Antioxidant enzyme B166
- Liver tissue 2D-page spot 71B
- PLP
- Peroxiredoxin V
- Peroxisomal antioxidant enzyme
- Prx-V
- TPx type VI
- Thioredoxin peroxidase PMP20
- Thioredoxin reductase
|
| Gene Name
| PRDX5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
|
| GO Classification
|
| Biological Process |
| negative regulation of apoptotic process |
| inflammatory response |
| positive regulation of collagen biosynthetic process |
| cellular response to reactive oxygen species |
| hydrogen peroxide catabolic process |
| NADPH oxidation |
| negative regulation of oxidoreductase activity |
| negative regulation of transcription from RNA polymerase III promoter |
| reactive nitrogen species metabolic process |
| regulation of apoptosis involved in tissue homeostasis |
| Cellular Component |
| cytosolic part |
| mitochondrion |
| perinuclear region of cytoplasm |
| nucleus |
| peroxisomal matrix |
| peroxisome |
| cytoplasmic vesicle |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| peroxiredoxin activity |
| antioxidant activity |
| peroxynitrite reductase activity |
| RNA polymerase III regulatory region DNA binding |
| peroxidase activity |
| protein dimerization activity |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| Process |
| cellular process |
| cellular homeostasis |
| cell redox homeostasis |
|
| Cellular Location
|
- Cytoplasm
- Mitochondrion
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Peroxisome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q13 |
| SNPs
| PRDX5 |
| Gene Sequence
|
>645 bp
ATGGGACTAGCTGGCGTGTGCGCCCTGAGACGCTCAGCGGGCTATATACTCGTCGGTGGG
GCCGGCGGTCAGTCTGCGGCAGCGGCAGCAAGACGGTGCAGTGAAGGAGAGTGGGCGTCT
GGCGGGGTCCGCAGTTTCAGCAGAGCCGCTGCAGCCATGGCCCCAATCAAGGTGGGAGAT
GCCATCCCAGCAGTGGAGGTGTTTGAAGGGGAGCCAGGGAACAAGGTGAACCTGGCAGAG
CTGTTCAAGGGCAAGAAGGGTGTGCTGTTTGGAGTTCCTGGGGCCTTCACCCCTGGATGT
TCCAAGACACACCTGCCAGGGTTTGTGGAGCAGGCTGAGGCTCTGAAGGCCAAGGGAGTC
CAGGTGGTGGCCTGTCTGAGTGTTAATGATGCCTTTGTGACTGGCGAGTGGGGCCGAGCC
CACAAGGCGGAAGGCAAGGTTCGGCTCCTGGCTGATCCCACTGGGGCCTTTGGGAAGGAG
ACAGACTTATTACTAGATGATTCGCTGGTGTCCATCTTTGGGAATCGACGTCTCAAGAGG
TTCTCCATGGTGGTACAGGATGGCATAGTGAAGGCCCTGAATGTGGAACCAGATGGCACA
GGCCTCACCTGCAGCCTGGCACCCAATATCATCTCACAGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 214 |
| Molecular Weight
| 22026.205 |
| Theoretical pI
| 8.575 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxiredoxin-5, mitochondrial
MGLAGVCALRRSAGYILVGGAGGQSAAAAARRCSEGEWASGGVRSFSRAAAAMAPIKVGD
AIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGV
QVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKR
FSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL
|
| External Links |
|---|
| GenBank ID Protein
| 6103724 |
| UniProtKB/Swiss-Prot ID
| P30044 |
| UniProtKB/Swiss-Prot Entry Name
| PRDX5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF110731 |
| GeneCard ID
| PRDX5 |
| GenAtlas ID
| PRDX5 |
| HGNC ID
| HGNC:9355 |
| References |
|---|
| General References
| Not Available |