| Identification |
|---|
| HMDB Protein ID
| CDBP01955 |
| Secondary Accession Numbers
| Not Available |
| Name
| Folate transporter 1 |
| Description
| Not Available |
| Synonyms
|
- FOLT
- IFC-1
- Intestinal folate carrier 1
- Placental folate transporter
- RFC
- Reduced folate carrier protein
- Solute carrier family 19 member 1
|
| Gene Name
| SLC19A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in folic acid binding |
| Specific Function
| Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.
|
| GO Classification
|
| Biological Process |
| folic acid metabolic process |
| Cellular Component |
| integral to plasma membrane |
| Component |
| membrane |
| cell part |
| Function |
| reduced folate carrier activity |
| active transmembrane transporter activity |
| binding |
| transmembrane transporter activity |
| folic acid binding |
| carboxylic acid binding |
| amino acid binding |
| transporter activity |
| secondary active transmembrane transporter activity |
| Molecular Function |
| methotrexate transporter activity |
| folic acid transporter activity |
| folic acid binding |
| reduced folate carrier activity |
| Process |
| establishment of localization |
| transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Vitamin digestion and absorption | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| 21q22.3 |
| SNPs
| SLC19A1 |
| Gene Sequence
|
>1776 bp
ATGGTGCCCTCCAGCCCAGCGGTGGAGAAGCAGGTGCCCGTGGAACCTGGGCCTGACCCC
GAGCTCCGGTCCTGGCGGCACCTCGTGTGCTACCTTTGCTTCTACGGCTTCATGGCGCAG
ATACGGCCAGGGGAGAGCTTCATCACCCCCTACCTCCTGGGGCCCGACAAGAACTTCACG
CGGGAGCAGGTCACGAACGAGATCACGCCGGTGTTGTCGTACTCCTACCTGGCCGTGCTG
GTGCCCGTGTTCCTGCTCACCGACTACCTGCGCTACACGCCGGTGCTGCTGCTGCAGGGG
CTCAGCTTCGTGTCGGTGTGGCTGCTGCTGCTGCTGGGCCACTCGGTGGCGCACATGCAG
CTCATGGAGCTCTTCTACAGCGTCACCATGGCCGCGCGCATCGCCTATTCCTCCTACATC
TTCTCTCTCGTGCGGCCCGCGCGCTACCAGCGTGTGGCCGGCTACTCGCGCGCTGCGGTG
CTGCTGGGCGTGTTCACCAGCTCCGTGCTGGGCCAGCTGCTGGTCACTGTGGGCCGAGTC
TCCTTCTCCACGCTCAACTACATCTCGCTGGCCTTCCTCACCTTCAGCGTGGTCCTCGCC
CTCTTCCTGAAGCGCCCCAAGCGCAGCCTCTTCTTCAACCGCGACGACCGGGGGCGGTGC
GAAACCTCGGCTTCGGAGCTGGAGCGCATGAATCCCGGCCCAGGCGGGAAGCTGGGACAC
GCCCTGCGGGTGGCCTGTGGGGACTCAGTGCTGGCGCGGATGCTGCGGGAGCTGGGGGAC
AGCCTGCGGCGGCCGCAGCTGCGCCTGTGGTCCCTCTGGTGGGTCTTCAACTCGGCCGGC
TACTACCTGGTGGTCTACTACGTGCACATCCTGTGGAACGAGGTGGACCCCACCACCAAC
AGTGCGCGGGTCTACAACGGCGCGGCAGATGCTGCCTCCACGCTGCTGGGCGCCATCACG
TCCTTCGCCGCGGGCTTCGTGAAGATCCGCTGGGCGCGCTGGTCCAAGCTGCTCATCGCG
GGCGTCACGGCCACGCAGGCGGGGCTGGTCTTCCTTCTGGCGCACACGCGCCACCCGAGC
AGCATCTGGCTGTGCTATGCGGCCTTCGTGCTGTTCCGCGGCTCCTACCAGTTCCTCGTG
CCCATCGCCACCTTTCAGATTGCATCTTCTCTGTCTAAAGAGCTCTGTGCCCTGGTCTTC
GGGGTCAACACGTTCTTTGCCACCATCGTCAAGACCATCATCACTTTCATTGTCTCGGAC
GTGCGGGGCCTGGGCCTCCCGGTCCGCAAGCAGTTCCAGTTATACTCCGTGTACTTCCTG
ATCCTGTCCATCATCTACTTCTTGGGGGCCATGCTGGATGGCCTGCGGCACTGCCAGCGG
GGCCACCACCCGCGGCAGCCCCCGGCCCAGGGCCTGAGGAGTGCCGCGGAGGAGAAGGCA
GCACAGGCACTGAGCGTGCAGGACAAGGGCCTCGGAGGCCTGCAGCCAGCCCAGAGCCCG
CCGCTTTCCCCAGAAGACAGCCTGGGGGCTGTGGGGCCAGCCTCCCTGGAGCAGAGACAG
AGCGACCCATACCTGGCCCAGGCCCCGGCCCCGCAGGCAGCTGAATTCCTGAGCCCAGTG
ACAACCCCTTCCCCCTGCACTCTGTGCTCCGCCCAAGCCTCAGGCCCTGAGGCTGCAGAT
GAGACTTGTCCCCAGCTGGCTGTCCATCCTCCTGGTGTCAGCAAGCTGGGTTTGCAGTGT
CTTCCAAGCGACGGTGTTCAGAATGTGAACCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 591 |
| Molecular Weight
| 54261.68 |
| Theoretical pI
| 9.514 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Folate transporter 1
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT
REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ
LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV
SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH
ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS
SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD
VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV
TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
|
| External Links |
|---|
| GenBank ID Protein
| 2209135 |
| UniProtKB/Swiss-Prot ID
| P41440 |
| UniProtKB/Swiss-Prot Entry Name
| S19A1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF004354 |
| GeneCard ID
| SLC19A1 |
| GenAtlas ID
| SLC19A1 |
| HGNC ID
| HGNC:10937 |
| References |
|---|
| General References
| Not Available |