Cannabis Compound Database: Showing Protein 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CDBP01938)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP01938

Secondary Accession Numbers

Not Available

Name

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Description

Not Available

Synonyms

CNP
CNPase

Gene Name

CNP

Protein Type

Enzyme

Biological Properties

General Function

Involved in 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity

Specific Function

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin (By similarity).

GO Classification

Biological Process
adult locomotory behavior
response to toxin
axonogenesis
cyclic nucleotide catabolic process
microtubule cytoskeleton organization
RNA metabolic process
synaptic transmission
Cellular Component
cytoplasm
plasma membrane
perinuclear region of cytoplasm
melanosome
extracellular space
microtubule
Component
intracellular
membrane
cell part
Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
cyclic-nucleotide phosphodiesterase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
phosphoric ester hydrolase activity
phosphoric diester hydrolase activity
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
Molecular Function
RNA binding
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
Process
rna metabolic process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
nucleoside monophosphate metabolic process
cell killing
nucleoside monophosphate catabolic process
cyclic nucleotide catabolic process

Cellular Location

Melanosome
Membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

17q21

SNPs

CNP

Gene Sequence

>1266 bp
ATGAACAGAGGCTTCTCCCGAAAAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCAAG
ATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTCAGGATGAG
GACACAGTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGA
AGCGGCAAGTCCACGCTGGCACGGGTCATCGTGGACAAGTACCGTGATGGCACCAAGATG
GTGTCGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCCTTCTCCGAGGAGTAC
AAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTG
CTTGATGACACCAACCACGAACGGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAG
TACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACTGTGCCCAG
CTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGG
CTGGAGAAGGACTTCCTGCCGCTCTACTTCGGCTGGTTCCTGACCAAGAAGAGCTCTGAG
ACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGGCCTTCAAG
AAGGAGCTGCGACAATTCGTCCCTGGGGATGAGCCCAGGGAGAAGATGGACTTGGTCACC
TACTTTGGAAAGAGACCCCCAGGCGTGCTGCATTGCACAACCAAGTTTTGTGACTACGGG
AAGGCTCCCGGGGCAGAGGAGTACGCTCAACAAGATGTGTTAAAGAAATCTTACTCCAAG
GCCTTCACGCTGACCATCTCTGCCCTCTTTGTGACACCCAAGACGACTGGGGCCCGGGTG
GAGTTAAGCGAGCAGCAACTGCAGTTGTGGCCGAGTGATGTGGACAAGCTGTCACCCACT
GACAACCTGCCGCGGGGGAGCCGCGCCCACATCACCCTCGGCTGTGCAGCTGACGTAGAG
GCCGTGCAGACGGGCCTTGACCTCTTAGAGATTCTGCGGCAGGAGAAGGGGGGCAGCCGA
GGCGAGGAGGTGGGCGAGCTAAGCCGGGGCAAGCTCTATTCCTTGGGCAATGGGCGCTGG
ATGCTGACCCTGGCCAAGAACATGGAGGTCAGGGCCATCTTCACGGGGTACTACGGGAAA
GGCAAACCTGTGCCCACGCAAGGTAGCCGGAAGGGGGGCGCCTTGCAGTCCTGCACCATC
ATATGA

Protein Properties

Number of Residues

421

Molecular Weight

47578.22

Theoretical pI

9.068

Pfam Domain Function

CNPase (PF05881 )
Zeta_toxin (PF06414 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>2',3'-cyclic-nucleotide 3'-phosphodiesterase
MNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVATLLECKTLFILRGLPG
SGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILV
LDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPG
LEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRQFVPGDEPREKMDLVT
YFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARV
ELSEQQLQLWPSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSR
GEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGKGKPVPTQGSRKGGALQSCTI
I

External Links

GenBank ID Protein

94721261

UniProtKB/Swiss-Prot ID

P09543

UniProtKB/Swiss-Prot Entry Name

CN37_HUMAN

PDB IDs