| Identification |
|---|
| HMDB Protein ID
| CDBP01935 |
| Secondary Accession Numbers
| Not Available |
| Name
| cAMP-responsive element modulator |
| Description
| Not Available |
| Synonyms
|
- ICER
- Inducible cAMP early repressor
|
| Gene Name
| CREM |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding transcription factor activity |
| Specific Function
| Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| sequence-specific dna binding transcription factor activity |
| binding |
| protein binding |
| nucleic acid binding |
| dna binding |
| protein dimerization activity |
| sequence-specific dna binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10p11.21 |
| SNPs
| CREM |
| Gene Sequence
|
>1050 bp
ATGAGCAAATGTGCAAGGAAAAAATATATTAAGACAAATCCAAGACAAATGACCATGGAA
ACAGTTGAATCCCAGCATGATGGAAGTATAACAGCTTCTTTGACAGAGAGCAAGTCTGCT
CATGTGCAGACTCAGACTGGCCAAAATTCAATCCCTGCTTTAGCTCAGGTTTCTGTGGCT
GGATCAGGCACCGGAAGAGGCTCCCCAGCTGTAACTCTAGTGCAGTTACCTTCGGGCCAA
ACTATACATGTCCAGGGAGTAATTCAGACACCACAGCCATCGGTTATTCAGTCATCACAA
ATACACACCGTTCAGGTAGCAGCAATTGCAGAGACAGATGAATCTGCAGAATCAGAAGGT
GTAATTGATTCTCATAAACGTAGAGAAATCCTTTCACGAAGACCCTCTTATAGGAAAATA
CTGAATGAACTGTCCTCTGATGTGCCTGGTGTTCCCAAGATTGAAGAAGAGAGATCAGAG
GAAGAAGGAACACCACCTAGTATTGCTACCATGGCAGTACCAACTAGCATATATCAGACT
AGCACGGGGCAATACATTGCTATAGCCCAAGGTGGAACAATCCAGATTTCTAACCCAGGA
TCTGATGGTGTTCAGGGACTGCAGGCATTAACAATGACAAATTCAGGAGCTCCTCCACCA
GGTGCTACAATTGTACAGTATGCAGCACAATCAGCTGATGGCACACAGCAGTTCTTTGTC
CCAGGCAGCCAGGTTGTTGTTCCAGCTGCCACTGGTGACATGCCAACTTACCAGATCCGA
GCTCCTACTGCTGCTTTGCCACAGGGAGTGGTGATGGCTGCATCGCCCGGAAGTTTGCAC
AGTCCCCAGCAGCTGGCAGAAGAAGCAACACGCAAACGAGAGCTAAGGCTAATGAAAAAC
AGGGAAGCTGCCAAAGAATGTCGACGTCGAAAGAAAGAATATGTAAAATGTCTGGAGAGC
CGAGTTGCAGTGCTGGAAGTCCAGAACAAGAAGCTTATAGAGGAACTTGAAACCTTGAAA
GACATTTGTTCTCCCAAAACAGATTACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 361 |
| Molecular Weight
| 38939.6 |
| Theoretical pI
| 6.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>cAMP-responsive element modulator
MSKCARKKYIKTNPRQMTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVA
GSGTRRGSPAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEG
VIDSHKRREILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQT
STGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFV
PGSQVVVQDEETELAPSHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEE
ATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTD
Y
|
| External Links |
|---|
| GenBank ID Protein
| 114630088 |
| UniProtKB/Swiss-Prot ID
| Q03060 |
| UniProtKB/Swiss-Prot Entry Name
| CREM_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| XM_001148291 |
| GeneCard ID
| CREM |
| GenAtlas ID
| CREM |
| HGNC ID
| HGNC:2352 |
| References |
|---|
| General References
| Not Available |