| Identification |
|---|
| HMDB Protein ID
| CDBP01916 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alpha-synuclein |
| Description
| Not Available |
| Synonyms
|
- NACP
- Non-A beta component of AD amyloid
- Non-A4 component of amyloid precursor
|
| Gene Name
| SNCA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in regulation of dopamine secretion |
| Specific Function
| May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule- associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation |
| GO Classification
|
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| regulation of dopamine secretion |
| regulation of cell communication |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q21 |
| SNPs
| SNCA |
| Gene Sequence
|
>423 bp
ATGGATGTATTCATGAAAGGACTTTCAAAGGCCAAGGAGGGAGTTGTGGCTGCTGCTGAG
AAAACCAAACAGGGTGTGGCAGAAGCAGCAGGAAAGACAAAAGAGGGTGTTCTCTATGTA
GGCTCCAAAACCAAGGAGGGAGTGGTGCATGGTGTGGCAACAGTGGCTGAGAAGACCAAA
GAGCAAGTGACAAATGTTGGAGGAGCAGTGGTGACGGGTGTGACAGCAGTAGCCCAGAAG
ACAGTGGAGGGAGCAGGGAGCATTGCAGCAGCCACTGGCTTTGTCAAAAAGGACCAGTTG
GGCAAGAATGAAGAAGGAGCCCCACAGGAAGGAATTCTGGAAGATATGCCTGTGGATCCT
GACAATGAGGCTTATGAAATGCCTTCTGAGGAAGGGTATCAAGACTACGAACCTGAAGCC
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 140 |
| Molecular Weight
| 14460.2 |
| Theoretical pI
| 4.37 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Alpha-synuclein
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK
EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP
DNEAYEMPSEEGYQDYEPEA
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P37840 |
| UniProtKB/Swiss-Prot Entry Name
| SYUA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| L08850 |
| GeneCard ID
| SNCA |
| GenAtlas ID
| SNCA |
| HGNC ID
| HGNC:11138 |
| References |
|---|
| General References
| Not Available |