Cannabis Compound Database: Showing Protein Transient receptor potential cation channel subfamily V member 6 (CDBP01904)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP01904

Secondary Accession Numbers

Not Available

Name

Transient receptor potential cation channel subfamily V member 6

Description

Not Available

Synonyms

CaT-L
CaT-like
CaT1
Calcium transport protein 1
ECaC2
Epithelial calcium channel 2
TrpV6

Gene Name

TRPV6

Protein Type

Receptor

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating

GO Classification

Component
integral to membrane
membrane
cell part
membrane part
intrinsic to membrane
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
transmembrane transport
ion transport

Cellular Location

Cell membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:7

Locus

7q34

SNPs

TRPV6

Gene Sequence

>2178 bp
ATGGGTTTGTCACTGCCCAAGGAGAAAGGGCTAATTCTCTGCCTATGGAGCAAGTTCTGC
AGATGGTTCCAGAGACGGGAGTCCTGGGCCCAGAGCCGAGATGAGCAGGACCTGCTGCAG
CAGAAGAGGATCTGGGAGTCTCCTCTCCTTCTAGCTGCCAAAGATAATGATGTCCAGGCC
CTGAACAAGTTGCTCAAGTATGAGGATTGCAAGGTGCACCATAGAGGAGCCATGGGGGAA
ACAGCGCTACACATAGCAGCCCTCTATGACAACCTGGAGGCCGCCATGGTGCTGATGGAG
GCTGCCCCGGAGCTGGTCTTTGAGCCCATGACATCTGAGCTCTATGAGGGTCAGACTGCA
CTGCACATCGCTGTTGTGAACCAGAACATGAACCTGGTGCGAGCCCTGCTTGCCCGCAGG
GCCAGTGTCTCTGCCAGAGCCACAGGCACTGCCTTCCGCCGTAGTCCCTGCAACCTCATC
TACTTTGGGGAGCACCCTTTGTCCTTTGCTGCCTGTGTGAACAGTGAGGAGATCGTGCGG
CTGCTCATTGAGCATGGAGCTGACATCCGGGCCCAGGACTCCCTGGGAAACACAGTGTTA
CACATCCTCATCCTCCAGCCCAACAAAACCTTTGCCTGCCAGATGTACAACCTGTTGCTG
TCCTACGACAGACATGGGGACCACCTGCAGCCCCTGGACCTCGTGCCCAATCACCAGGGT
CTCACCCCTTTCAAGCTGGCTGGAGTGGAGGGTAACACTGTGATGTTTCAGCACCTGATG
CAGAAGCGGAAGCACACCCAGTGGACGTATGGACCACTGACCTCGACTCTCTATGACCTC
ACAGAGATCGACTCCTCAGGGGATGAGCAGTCCCTGCTGGAACTTATCATCACCACCAAG
AAGCGGGAGGCTCGCCAGATCCTGGACCAGACGCCGGTGAAGGAGCTGGTGAGCCTCAAG
TGGAAGCGGTACGGGCGGCCGTACTTCTGCATGCTGGGTGCCATATATCTGCTGTACATC
ATCTGCTTCACCATGTGCTGCATCTACCGCCCCCTCAAGCCCAGGACCAATAACCGCACG
AGCCCCCGGGACAACACCCTCTTACAGCAGAAGCTACTTCAGGAAGCCTACATGACCCCT
AAGGACGATATCCGGCTGGTCGGGGAGCTGGTGACTGTCATTGGGGCTATCATCATCCTG
CTGGTAGAGGTTCCAGACATCTTCAGAATGGGGGTCACTCGCTTCTTTGGACAGACCATC
CTTGGGGGCCCATTCCATGTCCTCATCATCACCTATGCCTTCATGGTGCTGGTGACCATG
GTGATGCGGCTCATCAGTGCCAGCGGGGAGGTGGTACCCATGTCCTTTGCACTCGTGCTG
GGCTGGTGCAATGTCATGTACTTCGCCCGAGGATTCCAGATGCTAGGCCCCTTCACCATC
ATGATTCAGAAGATGATTTTTGGCGACCTGATGCGATTCTGCTGGCTGATGGCTGTGGTC
ATCCTGGGCTTTGCTTCAGCCTTCTATATCATCTTCCAGACAGAGGACCCCGAGGAGCTA
GGCCACTTCTACGACTACCCCATGGCCCTGTTCAGCACCTTCGAGCTGTTCCTTACCATC
ATCGATGGCCCAGCCAACTACAACGTGGACCTGCCCTTCATGTACAGCATCACCTATGCT
GCCTTTGCCATCATCGCCACACTGCTCATGCTCAACCTCCTCATTGCCATGATGGGCGAC
ACTCACTGGCGAGTGGCCCATGAGCGGGATGAGCTGTGGAGGGCCCAGATTGTGGCCACC
ACGGTGATGCTGGAGCGGAAGCTGCCTCGCTGCCTGTGGCCTCGCTCCGGGATCTGCGGA
CGGGAGTATGGCCTGGGAGACCGCTGGTTCCTGCGGGTGGAAGACAGGCAAGATCTCAAC
CGGCAGCGGATCCAACGCTACGCACAGGCCTTCCACACCCGGGGCTCTGAGGATTTGGAC
AAAGACTCAGTGGAAAAACTAGAGCTGGGCTGTCCCTTCAGCCCCCACCTGTCCCTTCCT
ATGCCCTCAGTGTCTCGAAGTACCTCCCGCAGCAGTGCCAACTGGGAAAGGCTTCGGCAA
GGGACCCTGAGGAGAGACCTGCGTGGGATAATCAACAGGGGTCTGGAGGACGGGGAGAGC
TGGGAATATCAGATCTGA

Protein Properties

Number of Residues

725

Molecular Weight

83209.2

Theoretical pI

7.66

Pfam Domain Function

Ank (PF00023 )
Ion_trans (PF00520 )

Signals

["None"]

Transmembrane Regions

["329-349", "388-408", "420-440", "449-469", "493-513", "557-577"]

Protein Sequence

>Transient receptor potential cation channel subfamily V member 6
MGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQA
LNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTA
LHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQG
LTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTK
KREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRT
SPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTI
LGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTI
MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTI
IDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVAT
TVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLD
KDSVEKLELGCPFSPHLSLPMPSVSRSTSRSSANWERLRQGTLRRDLRGIINRGLEDGES
WEYQI

External Links

GenBank ID Protein

11935057

UniProtKB/Swiss-Prot ID

Q9H1D0

UniProtKB/Swiss-Prot Entry Name

TRPV6_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF304463

GeneCard ID