| Identification |
|---|
| HMDB Protein ID
| CDBP01896 |
| Secondary Accession Numbers
| Not Available |
| Name
| Orexin |
| Description
| Not Available |
| Synonyms
|
- Hcrt
- Hcrt1
- Hcrt2
- Hypocretin
- Hypocretin-1
- Hypocretin-2
- Orexin-A
- Orexin-B
|
| Gene Name
| HCRT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in neuropeptide signaling pathway |
| Specific Function
| Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity |
| GO Classification
|
| Process |
| response to stimulus |
| behavior |
| feeding behavior |
| neuropeptide signaling pathway |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cytoplasmic vesicle
- Cell junction
- synapse
- Rough endoplasmic reticulum
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q21 |
| SNPs
| HCRT |
| Gene Sequence
|
>396 bp
ATGAACCTTCCTTCCACAAAGGTCTCCTGGGCCGCCGTGACGCTACTGCTGCTGCTGCTG
CTGCTGCCGCCCGCGCTGTTGTCGTCCGGGGCGGCTGCACAGCCCCTGCCCGACTGCTGT
CGTCAAAAGACTTGCTCTTGCCGCCTCTACGAGCTGCTGCACGGCGCGGGCAATCACGCG
GCCGGCATCCTCACGCTGGGCAAGCGGAGGTCCGGGCCCCCGGGCCTCCAGGGTCGGCTG
CAGCGCCTCCTGCAGGCCAGCGGCAACCACGCCGCGGGCATCCTGACCATGGGCCGCCGC
GCAGGCGCAGAGCCAGCGCCGCGCCCCTGCCTCGGGCGCCGCTGTTCCGCCCCGGCCGCC
GCCTCCGTCGCGCCCGGAGGACAGTCCGGGATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 131 |
| Molecular Weight
| 13362.5 |
| Theoretical pI
| 11.35 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Orexin
MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHA
AGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAA
ASVAPGGQSGI
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O43612 |
| UniProtKB/Swiss-Prot Entry Name
| OREX_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF041240 |
| GeneCard ID
| HCRT |
| GenAtlas ID
| HCRT |
| HGNC ID
| HGNC:4847 |
| References |
|---|
| General References
| Not Available |