| Identification |
|---|
| HMDB Protein ID
| CDBP01885 |
| Secondary Accession Numbers
| Not Available |
| Name
| Eosinophil cationic protein precursor |
| Description
| Not Available |
| Synonyms
|
- ECP
- RNase 3
- Ribonuclease 3
|
| Gene Name
| RNASE3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity |
| GO Classification
|
| Function |
| catalytic activity |
| hydrolase activity |
| nucleic acid binding |
| nuclease activity |
| endonuclease activity |
| endoribonuclease activity |
| endoribonuclease activity, producing 3'-phosphomonoesters |
| pancreatic ribonuclease activity |
| hydrolase activity, acting on ester bonds |
| binding |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:14 |
| Locus
| 14q24-q31 |
| SNPs
| RNASE3 |
| Gene Sequence
|
>483 bp
ATGGTTCCAAAACTGTTCACTTCCCAAATTTGTCTGCTTCTTCTGTTGGGGCTTATGGGT
GTGGAGGGCTCACTCCATGCCAGACCCCCACAGTTTACGAGGGCTCAGTGGTTTGCCATC
CAGCACATCAGTCTGAACCCCCCTCGATGCACCATTGCAATGCGGGCAATTAACAATTAT
CGATGGCGTTGCAAAAACCAAAATACTTTTCTTCGTACAACTTTTGCTAATGTAGTTAAT
GTTTGTGGTAACCAAAGTATACGCTGCCCTCATAACAGAACTCTCAACAATTGTCATCGG
AGTAGATTCCGGGTGCCTTTACTCCACTGTGACCTCATAAATCCAGGTGCACAGAATATT
TCAAACTGCAGGTATGCAGACAGACCAGGAAGGAGGTTCTATGTAGTTGCATGTGACAAC
AGAGATCCACGGGATTCTCCACGGTATCCTGTGGTTCCAGTTCACCTGGATACCACCATC
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 160 |
| Molecular Weight
| 18386.0 |
| Theoretical pI
| 10.33 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Eosinophil cationic protein precursor
MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNY
RWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNI
SNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
|
| External Links |
|---|
| GenBank ID Protein
| 31077 |
| UniProtKB/Swiss-Prot ID
| P12724 |
| UniProtKB/Swiss-Prot Entry Name
| ECP_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X15161 |
| GeneCard ID
| RNASE3 |
| GenAtlas ID
| RNASE3 |
| HGNC ID
| HGNC:10046 |
| References |
|---|
| General References
| Not Available |