| Identification |
|---|
| HMDB Protein ID
| CDBP01878 |
| Secondary Accession Numbers
| Not Available |
| Name
| Extracellular sulfatase Sulf-1 |
| Description
| Not Available |
| Synonyms
|
- hSulf-1
|
| Gene Name
| SULF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation |
| GO Classification
|
| Component |
| golgi apparatus |
| cell part |
| endoplasmic reticulum |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| cell surface |
| Function |
| cation binding |
| metal ion binding |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| sulfuric ester hydrolase activity |
| calcium ion binding |
| ion binding |
| Process |
| metabolic process |
|
| Cellular Location
|
- Golgi apparatus
- Endoplasmic reticulum
- Golgi stack
- Cell surface
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q13.1 |
| SNPs
| SULF1 |
| Gene Sequence
|
>2616 bp
ATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGC
CTCTGTTCGACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAAC
ATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTGGAGCTGGGGTCCCTG
CAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCC
TTTGTGACTACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTG
CACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATG
CATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGCCTTTTTT
GGAAAATACCTCAATGAATATAATGGCAGCTACATCCCCCCTGGGTGGCGAGAATGGCTT
GGATTAATCAAGAATTCTCGCTTCTATAATTACACTGTTTGTCGCAATGGCATCAAAGAA
AAGCATGGATTTGATTATGCAAAGGACTACTTCACAGACTTAATCACTAACGAGAGCATT
AATTACTTCAAAATGTCTAAGAGAATGTATCCCCATAGGCCCGTTATGATGGTGATCAGC
CACGCTGCGCCCCACGGCCCCGAGGACTCAGCCCCACAGTTTTCTAAACTGTACCCCAAT
GCTTCCCAACACATAACTCCTAGTTATAACTATGCACCAAATATGGATAAACACTGGATT
ATGCAGTACACAGGACCAATGCTGCCCATCCACATGGAATTTACAAACATTCTACAGCGC
AAAAGGCTCCAGACTTTGATGTCAGTGGATGATTCTGTGGAGAGGCTGTATAACATGCTC
GTGGAGACGGGGGAGCTGGAGAATACTTACATCATTTACACCGCCGACCATGGTTACCAT
ATTGGGCAGTTTGGACTGGTCAAGGGGAAATCCATGCCATATGACTTTGATATTCGTGTG
CCTTTTTTTATTCGTGGTCCAAGTGTAGAACCAGGATCAATAGTCCCACAGATCGTTCTC
AACATTGACTTGGCCCCCACGATCCTGGATATTGCTGGGCTCGACACACCTCCTGATGTG
GACGGCAAGTCTGTCCTCAAACTTCTGGACCCAGAAAAGCCAGGTAACAGGTTTCGAACA
AACAAGAAGGCCAAAATTTGGCGTGATACATTCCTAGTGGAAAGAGGCAAATTTCTACGT
AAGAAGGAAGAATCCAGCAAGAATATCCAACAGTCAAATCACTTGCCCAAATATGAACGG
GTCAAAGAACTATGCCAGCAGGCCAGGTACCAGACAGCCTGTGAACAACCGGGGCAGAAG
TGGCAATGCATTGAGGATACATCTGGCAAGCTTCGAATTCACAAGTGTAAAGGACCCAGT
GACCTGCTCACAGTCCGGCAGAGCACGCGGAACCTCTACGCTCGCGGCTTCCATGACAAA
GACAAAGAGTGCAGTTGTAGGGAGTCTGGTTACCGTGCCAGCAGAAGCCAAAGAAAGAGT
CAACGGCAATTCTTGAGAAACCAGGGGACTCCAAAGTACAAGCCCAGATTTGTCCATACT
CGGCAGACACGTTCCTTGTCCGTCGAATTTGAAGGTGAAATATATGACATAAATCTGGAA
GAAGAAGAAGAATTGCAAGTGTTGCAACCAAGAAACATTGCTAAGCGTCATGATGAAGGC
CACAAGGGGCCAAGAGATCTCCAGGCTTCCAGTGGTGGCAACAGGGGCAGGATGCTGGCA
GATAGCAGCAACGCCGTGGGCCCACCTACCACTGTCCGAGTGACACACAAGTGTTTTATT
CTTCCCAATGACTCTATCCATTGTGAGAGAGAACTGTACCAATCGGCCAGAGCGTGGAAG
GACCATAAGGCATACATTGACAAAGAGATTGAAGCTCTGCAAGATAAAATTAAGAATTTA
AGAGAAGTGAGAGGACATCTGAAGAGAAGGAAGCCTGAGGAATGTAGCTGCAGTAAACAA
AGCTATTACAATAAAGAGAAAGGTGTAAAAAAGCAAGAGAAATTAAAGAGCCATCTTCAC
CCATTCAAGGAGGCTGCTCAGGAAGTAGATAGCAAACTGCAACTTTTCAAGGAGAACAAC
CGTAGGAGGAAGAAGGAGAGGAAGGAGAAGAGACGGCAGAGGAAGGGGGAAGAGTGCAGC
CTGCCTGGCCTCACTTGCTTCACGCATGACAACAACCACTGGCAGACAGCCCCGTTCTGG
AACCTGGGATCTTTCTGTGCTTGCACGAGTTCTAACAATAACACCTACTGGTGTTTGCGT
ACAGTTAATGAGACGCATAATTTTCTTTTCTGTGAGTTTGCTACTGGCTTTTTGGAGTAT
TTTGATATGAATACAGATCCTTATCAGCTCACAAATACAGTGCACACGGTAGAACGAGGC
ATTTTGAATCAGCTACACGTACAACTAATGGAGCTCAGAAGCTGTCAAGGATATAAGCAG
TGCAACCCAAGACCTAAGAATCTTGATGTTGGAAATAAAGATGGAGGAAGCTATGACCTA
CACAGAGGACAGTTATGGGATGGATGGGAAGGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 871 |
| Molecular Weight
| 101026.1 |
| Theoretical pI
| 9.4 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Extracellular sulfatase Sulf-1
MKYSCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSL
QVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM
HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE
KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPN
ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNML
VETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVL
NIDLAPTILDIAGLDTPPDVDGKSVLKLLDPEKPGNRFRTNKKAKIWRDTFLVERGKFLR
KKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQPGQKWQCIEDTSGKLRIHKCKGPS
DLLTVRQSTRNLYARGFHDKDKECSCRESGYRASRSQRKSQRQFLRNQGTPKYKPRFVHT
RQTRSLSVEFEGEIYDINLEEEEELQVLQPRNIAKRHDEGHKGPRDLQASSGGNRGRMLA
DSSNAVGPPTTVRVTHKCFILPNDSIHCERELYQSARAWKDHKAYIDKEIEALQDKIKNL
REVRGHLKRRKPEECSCSKQSYYNKEKGVKKQEKLKSHLHPFKEAAQEVDSKLQLFKENN
RRRKKERKEKRRQRKGEECSLPGLTCFTHDNNHWQTAPFWNLGSFCACTSSNNNTYWCLR
TVNETHNFLFCEFATGFLEYFDMNTDPYQLTNTVHTVERGILNQLHVQLMELRSCQGYKQ
CNPRPKNLDVGNKDGGSYDLHRGQLWDGWEG
|
| External Links |
|---|
| GenBank ID Protein
| 189571638 |
| UniProtKB/Swiss-Prot ID
| Q8IWU6 |
| UniProtKB/Swiss-Prot Entry Name
| SULF1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001128204.1 |
| GeneCard ID
| SULF1 |
| GenAtlas ID
| SULF1 |
| HGNC ID
| HGNC:20391 |
| References |
|---|
| General References
| Not Available |