Identification |
HMDB Protein ID
| CDBP01865 |
Secondary Accession Numbers
| Not Available |
Name
| Endothelin-1 receptor |
Description
| Not Available |
Synonyms
|
- ET-A
- ETA-R
- Endothelin A receptor
- hET-AR
|
Gene Name
| EDNRA |
Protein Type
| Receptor |
Biological Properties |
General Function
| Involved in G-protein coupled receptor protein signaling pathway |
Specific Function
| Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is:ET1 > ET2 >> ET3 |
GO Classification
|
Component |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
peptide receptor activity |
peptide receptor activity, g-protein coupled |
receptor activity |
molecular transducer activity |
signal transducer activity |
endothelin receptor activity |
Process |
signaling |
signaling pathway |
cell surface receptor linked signaling pathway |
g-protein coupled receptor protein signaling pathway |
|
Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:4 |
Locus
| 4q31.22 |
SNPs
| EDNRA |
Gene Sequence
|
>1284 bp
ATGGAAACCCTTTGCCTCAGGGCATCCTTTTGGCTGGCACTGGTTGGATGTGTAATCAGT
GATAATCCTGAGAGATACAGCACAAATCTAAGCAATCATGTGGATGATTTCACCACTTTT
CGTGGCACAGAGCTCAGCTTCCTGGTTACCACTCATCAACCCACTAATTTGGTCCTACCC
AGCAATGGCTCAATGCACAACTATTGCCCACAGCAGACTAAAATTACTTCAGCTTTCAAA
TACATTAACACTGTGATATCTTGTACTATTTTCATCGTGGGAATGGTGGGGAATGCAACT
CTGCTCAGGATCATTTACCAGAACAAATGTATGAGGAATGGCCCCAACGCGCTGATAGCC
AGTCTTGCCCTTGGAGACCTTATCTATGTGGTCATTGATCTCCCTATCAATGTATTTAAG
CTGCTGGCTGGGCGCTGGCCTTTTGATCACAATGACTTTGGCGTATTTCTTTGCAAGCTG
TTCCCCTTTTTGCAGAAGTCCTCGGTGGGGATCACCGTCCTCAACCTCTGCGCTCTTAGT
GTTGACAGGTACAGAGCAGTTGCCTCCTGGAGTCGTGTTCAGGGAATTGGGATTCCTTTG
GTAACTGCCATTGAAATTGTCTCCATCTGGATCCTGTCCTTTATCCTGGCCATTCCTGAA
GCGATTGGCTTCGTCATGGTACCCTTTGAATATAGGGGTGAACAGCATAAAACCTGTATG
CTCAATGCCACATCAAAATTCATGGAGTTCTACCAAGATGTAAAGGACTGGTGGCTCTTC
GGGTTCTATTTCTGTATGCCCTTGGTGTGCACTGCGATCTTCTACACCCTCATGACTTGT
GAGATGTTGAACAGAAGGAATGGCAGCTTGAGAATTGCCCTCAGTGAACATCTTAAGCAG
CGTCGAGAAGTGGCAAAAACAGTTTTCTGCTTGGTTGTAATTTTTGCTCTTTGCTGGTTC
CCTCTTCATTTAAGCCGTATATTGAAGAAAACTGTGTATAACGAGATGGACAAGAACCGA
TGTGAATTACTTAGTTTCTTACTGCTCATGGATTACATCGGTATTAACTTGGCAACCATG
AATTCATGTATAAACCCCATAGCTCTGTATTTTGTGAGCAAGAAATTTAAAAATTGTTTC
CAGTCATGCCTCTGCTGCTGCTGTTACCAGTCCAAAAGTCTGATGACCTCGGTCCCCATG
AACGGAACAAGCATCCAGTGGAAGAACCACGATCAAAACAACCACAACACAGACCGGAGC
AGCCATAAGGACAGCATGAACTGA
|
Protein Properties |
Number of Residues
| 427 |
Molecular Weight
| 48721.8 |
Theoretical pI
| 8.41 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["81-102", "113-132", "160-181", "206-229", "257-278", "307-328", "348-372"]
|
Protein Sequence
|
>Endothelin-1 receptor
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P25101 |
UniProtKB/Swiss-Prot Entry Name
| EDNRA_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| S63938 |
GeneCard ID
| EDNRA |
GenAtlas ID
| EDNRA |
HGNC ID
| HGNC:3179 |
References |
General References
| Not Available |