| Identification |
|---|
| HMDB Protein ID
| CDBP01857 |
| Secondary Accession Numbers
| Not Available |
| Name
| Homer protein homolog 2 |
| Description
| Not Available |
| Synonyms
|
- Cupidin
- Homer-2
|
| Gene Name
| HOMER2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
- Cell junction
- Cell junction
- synapse
- synapse
- postsynaptic cell membrane
- postsynaptic density
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q24.3 |
| SNPs
| HOMER2 |
| Gene Sequence
|
>1065 bp
ATGGGAGAACAGCCCATCTTCACCACCCGAGCGCATGTCTTCCAGATTGACCCCAACACC
AAGAAGAACTGGATGCCTGCGAGCAAGCAGGCGGTCACCGTTTCCTACTTCTATGATGTC
ACAAGGAACAGCTATCGGATCATCAGTGTGGACGGAGCCAAGGTGATCATAAACAGCACA
ATCACACCGAATATGACCTTCACCAAAACGTCACAGAAGTTTGGGCAGTGGGCCGACAGC
AGAGCCAACACAGTGTTTGGTTTGGGGTTTTCCTCTGAGCAGCAGCTGACAAAGTTTGCA
GAGAAATTCCAGGAGGTGAAAGAAGCTGCCAAGATAGCCAAAGACAAGACGCAGGAGAAA
ATCGAGACCTCAAGTAATCATTCCCAAGAATCTGGGCGTGAAACCCCATCTTCTACTCAG
GCATCCAGTGTCAACGGGACGGACGATGAAAAGGCCTCTCACGCCGGTCCAGCCAACACA
CACCTGAAGTCTGAGAATGACAAGCTGAAGATTGCCTTGACGCAGAGCGCAGCCAACGTG
AAGAAGTGGGAGATCGAGCTGCAGACCCTTCGGGAGAGCAATGCACGGCTGACCACAGCA
CTGCAGGAGTCGGCAGCCAGTGTGGAGCAGTGGAAGAGGCAGTTCTCCATCTGCCGTGAT
GAGAATGACCGGCTCCGCAACAAGATTGATGAGCTGGAAGAACAATGCAGTGAGATCAAC
AGAGAGAAGGAGAAGAACACGCAGCTGAAGAGGAGGATCGAGGAGCTGGAGGCAGAGCTC
CGAGAAAAGGAGACAGAGCTGAAAGATCTCCGAAAACAAAGTGAAATCATACCTCAGCTC
ATGTCAGAGTGCGAATATGTCTCTGAGAAGCTAGAGGCGGCAGAGAGAGACAATCAAAAC
CTGGAAGACAAAGTGCGTTCCTTAAAGACAGACATTGAGGAGAGCAAATACCGACAGCGC
CACCTGAAGGTGGAGTTGAAGAGCTTCCTGGAGGTGCTGGACGGGAAGATTGACGACCTG
CATGACTTCCGCCGAGGGCTCTCCAAGCTGGGCACCGATAACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 40627.0 |
| Theoretical pI
| 6.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Homer protein homolog 2
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV
KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN
REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
|
| External Links |
|---|
| GenBank ID Protein
| 46249351 |
| UniProtKB/Swiss-Prot ID
| Q9NSB8 |
| UniProtKB/Swiss-Prot Entry Name
| HOME2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_199330.1 |
| GeneCard ID
| HOMER2 |
| GenAtlas ID
| HOMER2 |
| HGNC ID
| HGNC:17513 |
| References |
|---|
| General References
| Not Available |