| Identification |
|---|
| HMDB Protein ID
| CDBP01856 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ras association domain-containing protein 1 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| RASSF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in intracellular signaling pathway |
| Specific Function
| Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK4 during Fas- induced apoptosis. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage |
| GO Classification
|
| Function |
| binding |
| protein binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
|
| Cellular Location
|
- Isoform C:Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p21.3 |
| SNPs
| RASSF1 |
| Gene Sequence
|
>1035 bp
ATGTCGGGGGAGCCTGAGCTCATTGAGCTGCGGGAGCTGGCACCCGCTGGGCGCGCTGGG
AAGGGCCGCACCCGGCTGGAGCGTGCCAACGCGCTGCGCATCGCGCGGGGCACCGCGTGC
AACCCCACACGGCAGCTGGTCCCTGGCCGTGGCCACCGCTTCCAGCCCGCGGGGCCCGCC
ACGCACACGTGGTGCGACCTCTGTGGCGACTTCATCTGGGGCGTCGTGCGCAAAGGCCTG
CAGTGCGCGCGCCTCTCTGCAGATTGCAAGTTCACCTGCCACTACCGCTGCCGCGCGCTC
GTCTGCCTGGACTGTTGCGGGCCCCGGGACCTGGGCTGGGAACCCGCGGTGGAGCGGGAC
ACGAACGTGGACGAGCCTGTGGAGTGGGAGACACCTGACCTTTCTCAAGCTGAGATTGAG
CAGAAGATCAAGGAGTACAATGCCCAGATCAACAGCAACCTCTTCATGAGCTTGAACAAG
GACGGTTCTTACACAGGCTTCATCAAGGTTCAGCTGAAGCTGGTGCGCCCTGTCTCTGTG
CCCTCCAGCAAGAAGCCACCCTCCTTGCAGGATGCCCGGCGGGGCCCAGGACGGGGCACA
AGTGTCAGGCGCCGCACTTCCTTTTACCTGCCCAAGGATGCTGTCAAGCACCTGCATGTG
CTGTCACGCACAAGGGCACGTGAAGTCATTGAGGCCCTGCTGCGAAAGTTCTTGGTGGTG
GATGACCCCCGCAAGTTTGCACTCTTTGAGCGCGCTGAGCGTCACGGCCAAGTGTACTTG
CGGAAGCTGTTGGATGATGAGCAGCCCCTGCGGCTGCGGCTCCTGGCAGGGCCCAGTGAC
AAGGCCCTGAGCTTTGTCCTGAAGGAAAATGACTCTGGGGAGGTGAACTGGGACGCCTTC
AGCATGCCTGAACTACATAACTTCCTACGTATCCTGCAGCGGGAGGAGGAGGAGCACCTC
CGCCAGATCCTGCAGAAGTACTCCTATTGCCGCCAGAAGATCCAAGAGGCCCTGCACGCC
TGCCCCCTTGGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 344 |
| Molecular Weight
| 39218.6 |
| Theoretical pI
| 9.19 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras association domain-containing protein 1
MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA
THTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERD
TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV
PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV
DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF
SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
|
| External Links |
|---|
| GenBank ID Protein
| 25777684 |
| UniProtKB/Swiss-Prot ID
| Q9NS23 |
| UniProtKB/Swiss-Prot Entry Name
| RASF1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_170714.1 |
| GeneCard ID
| RASSF1 |
| GenAtlas ID
| RASSF1 |
| HGNC ID
| HGNC:9882 |
| References |
|---|
| General References
| Not Available |