Identification |
HMDB Protein ID
| CDBP01822 |
Secondary Accession Numbers
| Not Available |
Name
| Sodium-dependent serotonin transporter |
Description
| Not Available |
Synonyms
|
- 5HT transporter
- 5HTT
- Solute carrier family 6 member 4
|
Gene Name
| SLC6A4 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in neurotransmitter:sodium symporter activity |
Specific Function
| Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
|
GO Classification
|
Biological Process |
sperm ejaculation |
vasoconstriction |
cellular response to retinoic acid |
cellular response to cGMP |
positive regulation of cell cycle |
negative regulation of synaptic transmission, dopaminergic |
response to toxin |
negative regulation of organ growth |
positive regulation of gene expression |
thalamus development |
response to estradiol stimulus |
response to drug |
response to hypoxia |
response to nutrient |
negative regulation of neuron differentiation |
social behavior |
circadian rhythm |
memory |
protein oligomerization |
protein homooligomerization |
brain morphogenesis |
negative regulation of cerebellar granule cell precursor proliferation |
serotonin uptake |
Cellular Component |
cytosol |
membrane raft |
endomembrane system |
endosome membrane |
integral to plasma membrane |
Component |
membrane |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
integral to plasma membrane |
Function |
neurotransmitter transporter activity |
neurotransmitter:sodium symporter activity |
serotonin:sodium symporter activity |
transmembrane transporter activity |
transporter activity |
Molecular Function |
actin filament binding |
cocaine binding |
serotonin transmembrane transporter activity |
serotonin:sodium symporter activity |
Process |
neurotransmitter transport |
establishment of localization |
transport |
|
Cellular Location
|
- Cell membrane
- Endomembrane system
- Endosome membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Multi-pass membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Serotonergic synapse | Not Available | | Benzocaine Action Pathway | | Not Available | Bupivacaine Action Pathway | | Not Available | Chloroprocaine Action Pathway | | Not Available | Cocaine Action Pathway | | Not Available |
|
Gene Properties |
Chromosome Location
| 17 |
Locus
| 17q11.2 |
SNPs
| SLC6A4 |
Gene Sequence
|
>1893 bp
ATGGAGACGACGCCCTTGAATTCTCAGAAGCAGCTATCAGCGTGTGAAGATGGAGAAGAT
TGTCAGGAAAACGGAGTTCTACAGAAGGTTGTTCCCACCCCAGGGGACAAAGTGGAGTCC
GGGCAAATATCCAATGGGTACTCAGCAGTTCCAAGTCCTGGTGCGGGAGATGACACACGG
CACTCTATCCCAGCGACCACCACCACCCTAGTGGCTGAGCTTCATCAAGGGGAACGGGAG
ACCTGGGGCAAGAAGGTGGATTTCCTTCTCTCAGTGATTGGCTATGCTGTGGACCTGGGC
AATGTCTGGCGCTTCCCCTACATATGTTACCAGAATGGAGGGGGGGCATTCCTCCTCCCC
TACACCATCATGGCCATTTTTGGGGGAATCCCGCTCTTTTACATGGAGCTCGCACTGGGA
CAGTACCACCGAAATGGATGCATTTCAATATGGAGGAAAATCTGCCCGATTTTCAAAGGG
ATTGGTTATGCCATCTGCATCATTGCCTTTTACATTGCTTCCTACTACAACACCATCATG
GCCTGGGCGCTATACTACCTCATCTCCTCCTTCACGGACCAGCTGCCCTGGACCAGCTGC
AAGAACTCCTGGAACACTGGCAACTGCACCAATTACTTCTCCGAGGACAACATCACCTGG
ACCCTCCATTCCACGTCCCCTGCTGAAGAATTTTACACGCGCCACGTCCTGCAGATCCAC
CGGTCTAAGGGGCTCCAGGACCTGGGGGGCATCAGCTGGCAGCTGGCCCTCTGCATCATG
CTGATCTTCACTGTTATCTACTTCAGCATCTGGAAAGGCGTCAAGACCTCTGGCAAGGTG
GTGTGGGTGACAGCCACCTTCCCTTATATCATCCTTTCTGTCCTGCTGGTGAGGGGTGCC
ACCCTCCCTGGAGCCTGGAGGGGTGTTCTCTTCTACTTGAAACCCAATTGGCAGAAACTC
CTGGAGACAGGGGTGTGGATAGATGCAGCCGCTCAGATCTTCTTCTCTCTTGGTCCGGGC
TTTGGGGTCCTGCTGGCTTTTGCTAGCTACAACAAGTTCAACAACAACTGCTACCAAGAT
GCCCTGGTGACCAGCGTGGTGAACTGCATGACGAGCTTCGTTTCGGGATTTGTCATCTTC
ACAGTGCTCGGTTACATGGCTGAGATGAGGAATGAAGATGTGTCTGAGGTGGCCAAAGAC
GCAGGTCCCAGCCTCCTCTTCATCACGTATGCAGAAGCGATAGCCAACATGCCAGCGTCC
ACTTTCTTTGCCATCATCTTCTTTCTGATGTTAATCACGCTGGGCTTGGACAGCACGTTT
GCAGGCTTGGAGGGGGTGATCACGGCTGTGCTGGATGAGTTCCCACACGTCTGGGCCAAG
CGCCGGGAGCGGTTCGTGCTCGCCGTGGTCATCACCTGCTTCTTTGGATCCCTGGTCACC
CTGACTTTTGGAGGGGCCTACGTGGTGAAGCTGCTGGAGGAGTATGCCACGGGGCCCGCA
GTGCTCACTGTCGCGCTGATCGAAGCAGTCGCTGTGTCTTGGTTCTATGGCATCACTCAG
TTCTGCAGGGACGTGAAGGAAATGCTCGGCTTCAGCCCGGGGTGGTTCTGGAGGATCTGC
TGGGTGGCCATCAGCCCTCTGTTTCTCCTGTTCATCATTTGCAGTTTTCTGATGAGCCCG
CCACAACTACGACTTTTCCAATATAATTATCCTTACTGGAGTATCATCTTGGGTTACTGC
ATAGGAACCTCATCTTTCATTTGCATCCCCACATATATAGCTTATCGGTTGATCATCACT
CCAGGGACATTTAAAGAGCGTATTATTAAAAGTATTACCCCGGAGACACCAACAGAAATT
CCTTGTGGGGACATCCGCTTGAATGCTGTGTAA
|
Protein Properties |
Number of Residues
| 630 |
Molecular Weight
| 70324.165 |
Theoretical pI
| 6.246 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Sodium-dependent serotonin transporter
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
|
External Links |
GenBank ID Protein
| 36433 |
UniProtKB/Swiss-Prot ID
| P31645 |
UniProtKB/Swiss-Prot Entry Name
| SC6A4_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| X70697 |
GeneCard ID
| SLC6A4 |
GenAtlas ID
| SLC6A4 |
HGNC ID
| HGNC:11050 |
References |
General References
| Not Available |