| Identification |
|---|
| HMDB Protein ID
| CDBP01800 |
| Secondary Accession Numbers
| Not Available |
| Name
| Vascular endothelial growth factor A |
| Description
| Not Available |
| Synonyms
|
- VEGF-A
- VPF
- Vascular permeability factor
|
| Gene Name
| VEGFA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in growth factor activity |
| Specific Function
| Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| receptor binding |
| growth factor activity |
| binding |
| protein binding |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Bevacizumab Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p12 |
| SNPs
| VEGFA |
| Gene Sequence
|
>699 bp
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTTGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AAAAAATCAGTTCGAGGAAAGGGAAAGGGGCAAAAACGAAAGCGCAAGAAATCCCGGTAT
AAGTCCTGGAGCGTGTACGTTGGTGCCCGCTGCTGTCTAATGCCCTGGAGCCTCCCTGGC
CCCCATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAG
ACGTGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTA
AACGAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 232 |
| Molecular Weight
| 27042.2 |
| Theoretical pI
| 9.08 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Vascular endothelial growth factor A
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
|
| External Links |
|---|
| GenBank ID Protein
| 284172459 |
| UniProtKB/Swiss-Prot ID
| P15692 |
| UniProtKB/Swiss-Prot Entry Name
| VEGFA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001171623.1 |
| GeneCard ID
| VEGFA |
| GenAtlas ID
| VEGFA |
| HGNC ID
| HGNC:12680 |
| References |
|---|
| General References
| Not Available |