Identification |
HMDB Protein ID
| CDBP01761 |
Secondary Accession Numbers
| Not Available |
Name
| Carbonic anhydrase 2 |
Description
| Not Available |
Synonyms
|
- CA-II
- CAC
- Carbonate dehydratase II
- Carbonic anhydrase C
- Carbonic anhydrase II
|
Gene Name
| CA2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in carbonate dehydratase activity |
Specific Function
| Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.
|
GO Classification
|
Biological Process |
bicarbonate transport |
carbon dioxide transport |
morphogenesis of an epithelium |
odontogenesis of dentin-containing tooth |
positive regulation of bone resorption |
positive regulation of cellular pH reduction |
positive regulation of osteoclast differentiation |
secretion |
kidney development |
one-carbon metabolic process |
response to estrogen stimulus |
small molecule metabolic process |
response to zinc ion |
response to stress |
response to pH |
Cellular Component |
axon |
cytosol |
apical part of cell |
basolateral plasma membrane |
extracellular space |
microvillus |
Function |
ion binding |
cation binding |
metal ion binding |
binding |
catalytic activity |
carbonate dehydratase activity |
transition metal ion binding |
zinc ion binding |
lyase activity |
carbon-oxygen lyase activity |
hydro-lyase activity |
Molecular Function |
metal ion binding |
zinc ion binding |
carbonate dehydratase activity |
Process |
cellular metabolic process |
one-carbon metabolic process |
metabolic process |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Proximal tubule bicarbonate reclamation | Not Available | | Collecting duct acid secretion | Not Available | | Gastric acid secretion | Not Available | | Pancreatic secretion | Not Available | | Bile secretion | Not Available | |
|
Gene Properties |
Chromosome Location
| 8 |
Locus
| 8q22 |
SNPs
| CA2 |
Gene Sequence
|
>783 bp
ATGTCCCATCACTGGGGGTACGGCAAACACAACGGACCTGAGCACTGGCATAAGGACTTC
CCCATTGCCAAGGGAGAGCGCCAGTCCCCTGTTGACATCGACACTCATACAGCCAAGTAT
GACCCTTCCCTGAAGCCCCTGTCTGTTTCCTATGATCAAGCAACTTCCCTGAGGATCCTC
AACAATGGTCATGCTTTCAACGTGGAGTTTGATGACTCTCAGGACAAAGCAGTGCTCAAG
GGAGGACCCCTGGATGGCACTTACAGATTGATTCAGTTTCACTTTCACTGGGGTTCACTT
GATGGACAAGGTTCAGAGCATACTGTGGATAAAAAGAAATATGCTGCAGAACTTCACTTG
GTTCACTGGAACACCAAATATGGGGATTTTGGGAAAGCTGTGCAGCAACCTGATGGACTG
GCCGTTCTAGGTATTTTTTTGAAGGTTGGCAGCGCTAAACCGGGCCTTCAGAAAGTTGTT
GATGTGCTGGATTCCATTAAAACAAAGGGCAAGAGTGCTGACTTCACTAACTTCGATCCT
CGTGGCCTCCTTCCTGAATCCCTGGATTACTGGACCTACCCAGGCTCACTGACCACCCCT
CCTCTTCTGGAATGTGTGACCTGGATTGTGCTCAAGGAACCCATCAGCGTCAGCAGCGAG
CAGGTGTTGAAATTCCGTAAACTTAACTTCAATGGGGAGGGTGAACCCGAAGAACTGATG
GTGGACAACTGGCGCCCAGCTCAGCCACTGAAGAACAGGCAAATCAAAGCTTCCTTCAAA
TAA
|
Protein Properties |
Number of Residues
| 260 |
Molecular Weight
| 29245.895 |
Theoretical pI
| 7.405 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Carbonic anhydrase 2
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
External Links |
GenBank ID Protein
| 29587 |
UniProtKB/Swiss-Prot ID
| P00918 |
UniProtKB/Swiss-Prot Entry Name
| CAH2_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| Y00339 |
GeneCard ID
| CA2 |
GenAtlas ID
| CA2 |
HGNC ID
| HGNC:1373 |
References |
General References
| Not Available |