Identification
HMDB Protein ID CDBP01761
Secondary Accession Numbers Not Available
Name Carbonic anhydrase 2
Description Not Available
Synonyms
  1. CA-II
  2. CAC
  3. Carbonate dehydratase II
  4. Carbonic anhydrase C
  5. Carbonic anhydrase II
Gene Name CA2
Protein Type Enzyme
Biological Properties
General Function Involved in carbonate dehydratase activity
Specific Function Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.
GO Classification
Biological Process
bicarbonate transport
carbon dioxide transport
morphogenesis of an epithelium
odontogenesis of dentin-containing tooth
positive regulation of bone resorption
positive regulation of cellular pH reduction
positive regulation of osteoclast differentiation
secretion
kidney development
one-carbon metabolic process
response to estrogen stimulus
small molecule metabolic process
response to zinc ion
response to stress
response to pH
Cellular Component
axon
cytosol
apical part of cell
basolateral plasma membrane
extracellular space
microvillus
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
carbonate dehydratase activity
transition metal ion binding
zinc ion binding
lyase activity
carbon-oxygen lyase activity
hydro-lyase activity
Molecular Function
metal ion binding
zinc ion binding
carbonate dehydratase activity
Process
cellular metabolic process
one-carbon metabolic process
metabolic process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 8
Locus 8q22
SNPs CA2
Gene Sequence
>783 bp
ATGTCCCATCACTGGGGGTACGGCAAACACAACGGACCTGAGCACTGGCATAAGGACTTC
CCCATTGCCAAGGGAGAGCGCCAGTCCCCTGTTGACATCGACACTCATACAGCCAAGTAT
GACCCTTCCCTGAAGCCCCTGTCTGTTTCCTATGATCAAGCAACTTCCCTGAGGATCCTC
AACAATGGTCATGCTTTCAACGTGGAGTTTGATGACTCTCAGGACAAAGCAGTGCTCAAG
GGAGGACCCCTGGATGGCACTTACAGATTGATTCAGTTTCACTTTCACTGGGGTTCACTT
GATGGACAAGGTTCAGAGCATACTGTGGATAAAAAGAAATATGCTGCAGAACTTCACTTG
GTTCACTGGAACACCAAATATGGGGATTTTGGGAAAGCTGTGCAGCAACCTGATGGACTG
GCCGTTCTAGGTATTTTTTTGAAGGTTGGCAGCGCTAAACCGGGCCTTCAGAAAGTTGTT
GATGTGCTGGATTCCATTAAAACAAAGGGCAAGAGTGCTGACTTCACTAACTTCGATCCT
CGTGGCCTCCTTCCTGAATCCCTGGATTACTGGACCTACCCAGGCTCACTGACCACCCCT
CCTCTTCTGGAATGTGTGACCTGGATTGTGCTCAAGGAACCCATCAGCGTCAGCAGCGAG
CAGGTGTTGAAATTCCGTAAACTTAACTTCAATGGGGAGGGTGAACCCGAAGAACTGATG
GTGGACAACTGGCGCCCAGCTCAGCCACTGAAGAACAGGCAAATCAAAGCTTCCTTCAAA
TAA
Protein Properties
Number of Residues 260
Molecular Weight 29245.895
Theoretical pI 7.405
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Carbonic anhydrase 2
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
GenBank ID Protein 29587
UniProtKB/Swiss-Prot ID P00918
UniProtKB/Swiss-Prot Entry Name CAH2_HUMAN
PDB IDs
GenBank Gene ID Y00339
GeneCard ID CA2
GenAtlas ID CA2
HGNC ID HGNC:1373
References
General References Not Available