| Identification |
|---|
| HMDB Protein ID
| CDBP01755 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protocadherin-8 |
| Description
| Not Available |
| Synonyms
|
- Arcadlin
|
| Gene Name
| PCDH8 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Potential calcium-dependent cell-adhesion protein |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q21.1 |
| SNPs
| PCDH8 |
| Gene Sequence
|
>3213 bp
ATGAGTCCTGTGAGGCGTTGGGGCAGCCCCTGCCTTTTCCCCTTGCAGCTCTTCAGCCTC
TGCTGGGTGCTCTCAGTGGCCCAGAGCAAAACAGTCCGATACAGCACCTTCGAGGAGGAT
GCCCCCGGCACGGTCATCGGGACCCTGGCCGAGGACCTGCATATGAAAGTATCGGGTGAC
ACAAGCTTCCGCCTGATGAAGCAATTCAACAGCTCTCTGCTCCGGGTGCGCGAAGGCGAC
GGGCAGCTGACCGTCGGGGACGCCGGCCTGGACCGCGAGCGGCTGTGTGGCCAGGCCCCG
CAGTGCGTGCTGGCCTTCGATGTGGTCAGCTTCTCGCAGGAGCAGTTCCGGCTGGTGCAC
GTGGAGGTAGAGGTGAGGGACGTCAACGACCACGCGCCGCGCTTCCCCAGGGCCCAGATC
CCGGTAGAGGTGTCCGAGGGTGCGGCAGTGGGCACGCGCATCCCCTTGGAGGTGCCGGTG
GACGAGGACGTGGGCGCCAACGGGCTGCAGACCGTGCGCCTGGCCGAGCCGCACAGCCCC
TTTCGCGTGGAGCTGCAGACGCGAGCGGACGGCGCTCAGTGCGCAGACCTGGTGCTGCTG
CAGGAGCTGGACCGCGAGAGCCAGGCCGCCTACAGCCTGGAGCTGGTGGCCCAGGACGGC
GGCCGCCCGCCGCGCTCCGCCACGGCTGCCCTCAGCGTGCGCGTCCTGGATGCGAATGAC
CACAGCCCGGCCTTCCCGCAGGGCGCCGTGGCCGAAGTGGAGCTGGCGGAAGACGCGCCC
GTGGGCTCCCTGCTTCTCGACCTGGACGCAGCCGACCCCGACGAGGGACCTAACGGCGAC
GTGGTGTTCGCATTTGGCGCCCGCACCCCGCCGGAGGCGCGCCGCCTCTTTCGGCTTGAC
CCGCGATCAGGCCGCCTCACCCTGGCCGGGCCCGTGGACTACGAGCGTCAGGACACCTAC
GAGCTGGACGTGCGGGCGCAGGACCGCGGACCCGGGCCCCGCGCTGCCACCTGCAAGGTC
ATCGTGCGCATCCGAGACGTCAATGACAACGCACCCGACATCGCCATCACCCCGCTGGCC
GCCCCAGGCGCGCCGGCAACCTCACCCTTCGCCGCTGCCGCCGCCGCCGCTGCACTCGGG
GGAGCGGACGCTAGCTCGCCGGCGGGAGCCGGGACGCCGGAGGCTGGTGCCACTTCGCTG
GTGCCGGAGGGGGCGGCGCGCGAGAGCCTGGTGGCCCTGGTCAGCACCTCGGACAGGGAC
TCGGGCGCCAACGGGCAAGTGCGCTGCGCCCTCTATGGGCACGAGCACTTCCGGCTGCAG
CCGGCCTACGCGGGCAGCTACCTGGTGGTGACCGCGGCGTCGCTGGACCGCGAACGCATC
GCCGAGTACAACTTGACGCTGGTGGCCGAGGATCGCGGCGCGCCCCCGCTGCGCACAGTG
CGGCCCTACACGGTGCGTGTGGGCGACGAGAACGACAACGCGCCGCTCTTCACGCGGCCG
GTCTATGAGGTGTCGGTGCGCGAGAACAACCCGCCAGGCGCCTACCTGGCCACGGTGGCC
GCCCGCGACCGGGACCTGGGCCGCAACGGCCAGGTCACCTACCGGCTGCTGGAGGCCGAG
GTGGGCCGCGCCGGGGGCGCCGTGTCCACTTATGTCTCGGTGGACCCAGCTACCGGAGCC
ATCTACGCGCTGCGCAGCTTCGACTATGAGACGCTGCGCCAACTCGACGTTCGCATCCAA
GCTAGCGACGGCGGCTCCCCTCAGCTTTCCAGCAGCGCCCTAGTGCAAGTGCGCGTGCTG
GACCAGAACGACCATGCGCCAGTCCTGGTGCACCCGGCGCCAGCCAATGGCTCCCTAGAA
GTGGCGGTGCCTGGGCGCACCGCAAAGGACACGGTTGTGGCCCGTGTGCAGGCCCGGGAT
GCAGACGAGGGAGCCAACGGGGAGCTGGCGTTCGAGCTGCAGCAGCAGGAGCCGCGCGAA
GCCTTCGCCATCGGCCGCCGCACGGGGGAGATACTGCTCACCGGCGACCTCTCGCAGGAG
CCACCCGGTCGCGTGTTCAGGGCGCTCCTGGTCATATCCGACGGCGGCCGTCCCCCGCTC
ACCACCACCGCAACTGTCAGCTTCGTGGTAACAGCAGGGGGCGGGCGTGGGCCGGCTGCG
CCTGCCAGTGCAGGAAGCCCGGAGCGTTCCCGCCCGCCTGGCTCTCGGCTCGGGGTGTCC
GGGTCGGTGCTGCAATGGGACACGCCGCTGATCGTCATCATCGTGCTGGCCGGGAGCTGC
ACGCTGCTGCTGGCCGCCATCATCGCCATCGCCACCACCTGCAACCGCCGCAAGAAGGAG
GTGCGCAAAGGGGGGGCCCTCCGGGAAGAGCGGCCCGGGGCGGCGGGCGGCGGAGCCTCG
GCTCCCGGCTCCCCGGAGGAGGCCGCCCGGGGAGCCGGGCCCAGGCCCAACATGTTCGAC
GTGCTCACCTTCCCTGGCACCGGCAAAGCGCCCTTTGGCAGCCCCGCGGCGGACGCGCCT
CCGCCTGCGGTCGCCGCGGCCGAAGTGCCGGGCTCAGAGGGCGGCAGCGCCACTGGGGAA
AGCGCCTGTCACTTCGAGGGGCAGCAGCGGCTCCGCGGCGCGCACGCCGAGCCCTACGGT
GCCTCCCCGGGTTTTGGAAAGGAGCCGGCGCCCCCTGTGGCGGTGTGGAAAGGACACTCC
TTCAACACCATTTCTGGCAGAGAAGCAGAGAAGTTCAGCGGCAAAGACAGCGGTAAAGGG
GACAGTGATTTCAACGACAGCGATTCCGACATCAGCGGGGACGCTCTGAAAAAGGATCTC
ATCAACCACATGCAGAGTGGACTGTGGGCGTGCACCGCTGAGTGTAAGATCCTGGGCCAC
TCTGACCGCTGCTGGAGCCCATCCTGCAGCGGGCCCAACGCACATCCATCGCCTCACCCA
CCAGCCCAGATGTCAACCTTCTGTAAGAGCACGTCACTGCCTCGGGATCCTCTGCGCAGG
GACAATTACTACCAGGCCCAGCTGCCCAAGACAGTGGGGCTGCAGAGCGTCTATGAGAAA
GTACTGCACAGAGACTATGACAGGACAGTCACTCTGCTCTCCCCTCCCCGTCCAGGGAGG
CTCCCAGACCTGCAGGAGATTGGAGTACCCCTCTACCAGTCCCCTCCTGGCAGGTACCTG
TCCCCGAAGAAGGGAGCCAATGAAAATGTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1070 |
| Molecular Weight
| 113017.3 |
| Theoretical pI
| 5.2 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin-8
MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGD
TSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVH
VEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSP
FRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDAND
HSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLD
PRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLA
APGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRD
SGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTV
RPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAE
VGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVL
DQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPRE
AFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAA
PASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKE
VRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAP
PPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHS
FNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGH
SDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEK
VLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV
|
| External Links |
|---|
| GenBank ID Protein
| 6513853 |
| UniProtKB/Swiss-Prot ID
| O95206 |
| UniProtKB/Swiss-Prot Entry Name
| PCDH8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF061573 |
| GeneCard ID
| PCDH8 |
| GenAtlas ID
| PCDH8 |
| HGNC ID
| HGNC:8660 |
| References |
|---|
| General References
| Not Available |