| Identification |
|---|
| HMDB Protein ID
| CDBP01733 |
| Secondary Accession Numbers
| Not Available |
| Name
| Molybdopterin synthase sulfur carrier subunit |
| Description
| Not Available |
| Synonyms
|
- MOCO1-A
- MOCS2A
- Molybdenum cofactor synthesis protein 2 small subunit
- Molybdenum cofactor synthesis protein 2A
- Molybdopterin-synthase small subunit
- Sulfur carrier protein MOCS2A
|
| Gene Name
| MOCS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in Mo-molybdopterin cofactor biosynthetic process |
| Specific Function
| Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
|
| GO Classification
|
| Biological Process |
| water-soluble vitamin metabolic process |
| Mo-molybdopterin cofactor biosynthetic process |
| Cellular Component |
| cytosol |
| molybdopterin synthase complex |
| Molecular Function |
| nucleotide binding |
| Process |
| coenzyme metabolic process |
| mo-molybdopterin cofactor biosynthetic process |
| metabolic process |
| coenzyme biosynthetic process |
| sulfur metabolic process |
| cellular metabolic process |
| cofactor metabolic process |
|
| Cellular Location
|
- Cytoplasm
- cytosol
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | molybdopterin biosynthesis | Not Available | Not Available | | Folate biosynthesis | Not Available |  | | Sulfur relay system | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q11 |
| SNPs
| MOCS2 |
| Gene Sequence
|
>267 bp
ATGGTGCCGCTGTGCCAGGTTGAAGTATTGTATTTTGCAAAAAGTGCTGAAATAACAGGA
GTTCGTTCAGAGACCATTTCTGTGCCTCAAGAAATAAAAGCGTTGCAGCTGTGGAAGGAG
ATAGAAACTCGACATCCTGGATTGGCTGATGTTAGAAATCAGATAATATTTGCTGTTCGT
CAAGAATATGTCGAGCTTGGAGATCAGCTCCTCGTGCTTCAGCCTGGAGACGAAATTGCC
GTTATCCCCCCCATTAGTGGAGGATAG
|
| Protein Properties |
|---|
| Number of Residues
| 88 |
| Molecular Weight
| 9755.235 |
| Theoretical pI
| 4.702 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Molybdopterin synthase sulfur carrier subunit
MVPLCQVEVLYFAKSAEITGVRSETISVPQEIKALQLWKEIETRHPGLADVRNQIIFAVR
QEYVELGDQLLVLQPGDEIAVIPPISGG
|
| External Links |
|---|
| GenBank ID Protein
| 4262372 |
| UniProtKB/Swiss-Prot ID
| O96033 |
| UniProtKB/Swiss-Prot Entry Name
| MOC2A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF091871 |
| GeneCard ID
| MOCS2 |
| GenAtlas ID
| MOCS2 |
| HGNC ID
| HGNC:7193 |
| References |
|---|
| General References
| Not Available |