| Identification |
|---|
| HMDB Protein ID
| CDBP01714 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tenascin-R |
| Description
| Not Available |
| Synonyms
|
- Janusin
- Restrictin
- TN-R
|
| Gene Name
| TNR |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in receptor binding |
| Specific Function
| Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance |
| GO Classification
|
| Function |
| protein binding |
| receptor binding |
| binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
|
| Cellular Location
|
- Secreted
- extracellular space
- extracellular matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q24 |
| SNPs
| TNR |
| Gene Sequence
|
>4077 bp
ATGGGGGCAGATGGGGAAACAGTGGTTCTGAAGAACATGCTCATTGGCGTCAACCTGATC
CTTCTGGGCTCCATGATCAAGCCTTCAGAGTGTCAGCTGGAGGTCACCACAGAAAGGGTC
CAGAGACAGTCAGTGGAGGAGGAGGGAGGCATTGCCAACTACAACACGTCCAGCAAAGAG
CAGCCTGTGGTCTTCAACCACGTGTACAACATTAACGTGCCCTTGGACAACCTCTGCTCC
TCAGGGCTAGAGGCCTCTGCTGAGCAGGAGGTGAGTGCAGAAGACGAGACTCTGGCAGAG
TACATGGGCCAGACCTCAGACCACGAGAGCCAGGTTACCTTTACACACAGGATCAACTTC
CCCAAAAAGGCCTGTCCATGTGCCAGTTCAGCCCAGGTGCTGCAGGAGCTGCTGAGCCGG
ATCGAGATGCTGGAGAGGGAGGTGTCGGTGCTGCGAGACCAGTGCAACGCCAACTGCTGC
CAAGAAAGTGCTGCCACAGGACAACTGGACTATATCCCTCACTGCAGCGGCCACGGCAAC
TTTAGCTTTGAGTCCTGTGGCTGCATCTGCAACGAAGGCTGGTTTGGCAAGAATTGCTCG
GAGCCCTACTGCCCGCTGGGTTGCTCCAGCCGGGGGGTGTGTGTGGATGGCCAGTGCATC
TGTGACAGCGAGTACAGCGGGGATGACTGTTCCGAACTCCGGTGCCCAACAGACTGCAGC
TCCCGGGGGCTCTGCGTGGACGGTGAGTGTGTCTGTGAAGAGCCCTACACTGGCGAGGAC
TGCAGGGAACTGAGGTGCCCTGGGGACTGTTCGGGGAAGGGGAGATGTGCCAACGGTACC
TGTTTATGCGAGGAGGGCTACGTTGGTGAGGACTGCGGCCAGCGGCAGTGTCTGAATGCC
TGCAGTGGGCGAGGACAATGTGAGGAGGGGCTCTGCGTCTGTGAAGAGGGCTACCAGGGC
CCTGACTGCTCAGCAGTTGCCCCTCCAGAGGACTTGCGAGTGGCTGGTATCAGCGACAGG
TCCATTGAGCTGGAATGGGACGGGCCGATGGCAGTGACGGAATATGTGATCTCTTACCAG
CCGACGGCCCTGGGGGGCCTCCAGCTCCAGCAGCGGGTGCCTGGAGATTGGAGTGGTGTC
ACCATCACGGAGCTGGAGCCAGGTCTCACCTACAACATCAGCGTCTACGCTGTCATTAGC
AACATCCTCAGCCTTCCCATCACTGCCAAGGTGGCCACCCATCTCTCCACTCCTCAAGGG
CTACAATTTAAGACGATCACAGAGACCACCGTGGAGGTGCAGTGGGAGCCCTTCTCATTT
TCCTTCGATGGGTGGGAAATCAGCTTCATTCCAAAGAACAATGAAGGGGGAGTGATTGCT
CAGGTCCCCAGCGATGTTACGTCCTTTAACCAGACAGGACTAAAGCCTGGGGAGGAATAC
ATTGTCAATGTGGTGGCTCTGAAAGAACAGGCCCGCAGCCCCCCTACCTCGGCCAGCGTC
TCCACAGTCATTGACGGCCCCACGCAGATCCTGGTTCGCGATGTCTCGGACACCGTGGCT
TTTGTGGAGTGGATTCCCCCTCGAGCCAAAGTCGATTTCATTCTTTTGAAATATGGCCTG
GTGGGCGGGGAAGGTGGGAGGACCACCTTCCGGCTGCAGCCTCCCCTGAGCCAATACTCA
GTGCAGGCCCTGCGGCCTGGCTCCCGATACGAGGTGTCAGTCAGTGCCGTCCGAGGGACC
AACGAGAGCGATTCTGCCACCACTCAGTTCACAACAGAGATCGATGCCCCCAAGAACTTG
CGAGTTGGTTCTCGCACAGCAACCAGCCTTGACCTCGAGTGGGATAACAGTGAAGCCGAA
GTTCAGGAGTACAAGGTTGTGTACATCACCCTGGCGGGTGAGCAATATCATGAGGTACTG
GTCCCCAGGGGCATTGGTCCAACCACCAGGGCCACCCTGACAGATCTGGTACCTGGCACT
GAGTATGGAGTTGGAATATCTGCCGTCATGAACTCACAGCAAAGCGTGCCAGCCACCATG
AATGCCAGGACTGAACTTGACAGTCCCCGAGACCTCATGGTGACAGCCTCCTCGGAGACC
TCCATCTCCCTCATCTGGACCAAGGCCAGTGGCCCCATTGACCACTACCGAATTACCTTT
ACCCCATCCTCTGGGATTGCCTCAGAAGTCACCGTACCCAAGGACAGGACCTCATACACA
CTAACAGATCTAGAGCCTGGGGCAGAGTACATCATTTCCGTCACTGCTGAGAGGGGTCGG
CAGCAGAGCTTGGAGTCCACTGTGGATGCTTTCACAGGCTTCCGTCCCATCTCTCATCTG
CACTTTTCTCATGTGACCTCCTCCAGTGTGAACATCACTTGGAGTGATCCATCTCCCCCA
GCAGACAGACTCATTCTTAACTACAGCCCCAGGGATGAGGAGGAAGAGATGATGGAGGTC
TCCCTGGATGCCACCAAGAGGCATGCTGTCCTGATGGGCCTGCAACCAGCCACAGAGTAT
ATTGTGAACCTTGTGGCTGTCCATGGCACAGTGACCTCTGAGCCCATTGTGGGCTCCATC
ACCACAGGAATTGATCCCCCAAAAGACATCACAATTAGCAATGTGACCAAGGACTCAGTG
ATGGTCTCCTGGAGCCCTCCTGTTGCATCTTTCGATTACTACCGAGTATCATATCGACCC
ACCCAAGTGGGACGACTAGACAGCTCAGTGGTGCCCAACACTGTGACAGAATTCACCATC
ACCAGACTGAACCCAGCTACCGAATACGAAATCAGCCTCAACAGCGTGCGGGGCAGGGAG
GAAAGCGAGCGCATCTGTACTCTTGTGCACACAGCCATGGACAACCCTGTGGATCTGATT
GCTACCAATATCACTCCAACAGAAGCCCTGCTGCAGTGGAAGGCACCAGTGGGTGAGGTG
GAGAACTACGTCATTGTTCTTACACACTTTGCAGTCGCTGGAGAGACCATCCTTGTTGAC
GGAGTCAGTGAGGAATTTCGGCTTGTTGACCTGCTTCCTAGCACCCACTATACTGCCACC
ATGTATGCCACCAATGGACCTCTCACCAGTGGCACCATCAGCACCAACTTTTCTACTCTC
CTGGACCCTCCGGCAAACCTGACAGCCAGTGAAGTCACCAGACAAAGTGCCCTGATCTCC
TGGCAGCCTCCCAGGGCAGAGATTGAAAATTATGTCTTGACCTACAAATCCACCGACGGA
AGCCGCAAGGAGCTGATTGTGGATGCAGAAGACACCTGGATTCGACTGGAGGGCCTGTTG
GAGAACACAGACTACACGGTGCTCCTGCAGGCAGCACAGGACACCACGTGGAGCAGCATC
ACCTCCACCGCTTTCACCACAGGAGGCCGGGTGTTCCCTCATCCCCAAGACTGTGCCCAG
CATTTGATGAATGGAGACACTTTGAGTGGGGTTTACCCCATCTTCCTCAATGGGGAGCTG
AGCCAGAAATTACAAGTGTACTGTGATATGACCACCGACGGGGGCGGCTGGATTGTATTC
CAGAGGCGGCAGAATGGCCAAACTGATTTTTTCCGGAAATGGGCTGATTACCGTGTTGGC
TTCGGGAACGTGGAGGATGAGTTCTGGCTGGGGCTGGACAATATACACAGGATCACATCC
CAGGGCCGCTATGAGCTGCGCGTGGACATGCGGGATGGCCAGGAGGCCGCCTTCGCCTCC
TACGACAGGTTCTCTGTCGAGGACAGCAGAAACCTGTACAAACTCCGCATAGGAAGCTAC
AACGGCACTGCGGGGGACTCCCTCAGCTATCATCAAGGACGCCCTTTCTCCACAGAGGAT
AGAGACAATGATGTTGCAGTGACTAACTGTGCCATGTCGTACAAGGGAGCATGGTGGTAT
AAGAACTGCCACCGGACCAACCTCAATGGGAAGTACGGGGAGTCCAGGCACAGTCAGGGC
ATCAACTGGTACCATTGGAAAGGCCATGAGTTCTCCATCCCCTTTGTGGAAATGAAGATG
CGCCCCTACAACCACCGTCTCATGGCAGGGAGAAAACGGCAGTCCTTACAGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1358 |
| Molecular Weight
| 149546.7 |
| Theoretical pI
| 4.44 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tenascin-R
MGADGETVVLKNMLIGVNLILLGSMIKPSECQLEVTTERVQRQSVEEEGGIANYNTSSKE
QPVVFNHVYNINVPLDNLCSSGLEASAEQEVSAEDETLAEYMGQTSDHESQVTFTHRINF
PKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNANCCQESAATGQLDYIPHCSGHGN
FSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCS
SRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGRCANGTCLCEEGYVGEDCGQRQCLNA
CSGRGQCEEGLCVCEEGYQGPDCSAVAPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQ
PTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQG
LQFKTITETTVEVQWEPFSFSFDGWEISFIPKNNEGGVIAQVPSDVTSFNQTGLKPGEEY
IVNVVALKEQARSPPTSASVSTVIDGPTQILVRDVSDTVAFVEWIPPRAKVDFILLKYGL
VGGEGGRTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRGTNESDSATTQFTTEIDAPKNL
RVGSRTATSLDLEWDNSEAEVQEYKVVYSTLAGEQYHEVLVPRGIGPTTRATLTDLVPGT
EYGVGISAVMNSQQSVPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITF
TPSSGIASEVTVPKDRTSYTLTDLEPGAEYIISVTAERGRQQSLESTVDAFTGFRPISHL
HFSHVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVSLDATKRHAVLMGLQPATEY
IVNLVAVHGTVTSEPIVGSITTGIDPPKDITISNVTKDSVMVSWSPPVASFDYYRVSYRP
TQVGRLDSSVVPNTVTEFTITRLNPATEYEISLNSVRGREESERICTLVHTAMDNPVDLI
ATNITPTEALLQWKAPVGEVENYVIVLTHFAVAGETILVDGVSEEFRLVDLLPSTHYTAT
MYATNGPLTSGTISTNFSTLLDPPANLTASEVTRQSALISWQPPRAEIENYVLTYKSTDG
SRKELIVDAEDTWIRLEGLLENTDYTVLLQAAQDTTWSSITSTAFTTGGRVFPHPQDCAQ
HLMNGDTLSGVYPIFLNGELSQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVG
FGNVEDEFWLGLDNIHRITSQGRYELRVDMRDGQEAAFASYDRFSVEDSRNLYKLRIGSY
NGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQG
INWYHWKGHEFSIPFVEMKMRPYNHRLMAGRKRQSLQF
|
| External Links |
|---|
| GenBank ID Protein
| 1617316 |
| UniProtKB/Swiss-Prot ID
| Q92752 |
| UniProtKB/Swiss-Prot Entry Name
| TENR_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X98085 |
| GeneCard ID
| TNR |
| GenAtlas ID
| TNR |
| HGNC ID
| HGNC:11953 |
| References |
|---|
| General References
| Not Available |