1713 CDBP01712 Histone-lysine N-methyltransferase MLL Q03164 MLL1_HUMAN true true Enzyme Homo_sapiens MLL 3969 432047.735 9.072 Involved in DNA binding Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. 2AGH;2J2S;2JYI;2KKF;2KU7;2KYU;2W5Y;2W5Z;3EG6;3EMH;3LQH;3LQI;3LQJ;3P4F;3U85;3U88;4ESG;4GQ6 AY373585 34305635 MLL 11 11q23 MLL HGNC:7132 true hsa:4297 NP_001184033.1:NM_001197104.1;NP_005924.2:NM_005933.3 Heart, lung, brain and T- and B-lymphocytes. MLL cleavage product N320 heterodimerizes with MLL cleavage product C180 (via SET and FYRC domains). Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, HCFC2, WDR5, DPY30 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with WDR5; the interaction is direct. Interacts with KAT8/MOF; the interaction is direct. Interacts with SBF1 and PPP1R15A 2020-06-12T23:06:58Z 2020-07-28T02:27:09Z 0 1 1