Identification |
HMDB Protein ID
| CDBP01687 |
Secondary Accession Numbers
| Not Available |
Name
| Pantetheinase |
Description
| Not Available |
Synonyms
|
- Pantetheine hydrolase
- Tiff66
- Vanin-1
- Vascular non-inflammatory molecule 1
|
Gene Name
| VNN1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
Specific Function
| Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
|
GO Classification
|
Biological Process |
acute inflammatory response |
negative regulation of apoptotic process |
cellular component movement |
response to oxidative stress |
pantothenate metabolic process |
innate immune response |
cell-cell adhesion |
chronic inflammatory response |
positive regulation of T cell differentiation in thymus |
Cellular Component |
anchored to membrane |
plasma membrane |
integral to membrane |
Function |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
catalytic activity |
hydrolase activity |
Molecular Function |
GPI anchor binding |
pantetheine hydrolase activity |
Process |
metabolic process |
nitrogen compound metabolic process |
|
Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor (Potential)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Pantothenate and CoA Biosynthesis | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000032/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000032/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000032/thumb?image_type=simple) | ![Map00770](https://www.genome.jp/kegg/misc/thumbnail/map00770.gif) |
|
Gene Properties |
Chromosome Location
| 6 |
Locus
| 6q23-q24 |
SNPs
| VNN1 |
Gene Sequence
|
>1542 bp
ATGACTACTCAGTTGCCAGCTTACGTGGCAATTTTGCTTTTCTATGTCTCAAGAGCCAGC
TGCCAGGACACTTTCATTGCAGCTGTTTATGAGCATGCAGCGATATTGCCCAATGCCACC
CTAACACCAGTGTCTCGTGAGGAGGCTTTGGCATTAATGAATCGGAATCTGGACATTTTG
GAAGGAGCGATCACATCAGCAGCAGATCAGGGTGCGCATATTATTGTGACTCCAGAAGAT
GCTATTTATGGCTGGAACTTCAACAGGGACTCTCTCTACCCATATTTGGAGGACATCCCA
GACCCTGAAGTAAACTGGATCCCCTGTAATAATCGTAACAGATTTGGCCAGACCCCAGTA
CAAGAAAGACTCAGCTGCCTGGCCAAGAACAACTCTATCTATGTTGTGGCAAATATTGGG
GACAAGAAGCCATGCGATACCAGTGATCCTCAGTGTCCCCCTGATGGCCGTTACCAATAC
AACACTGATGTGGTATTTGATTCTCAAGGAAAACTGGTGGCACGCTACCATAAGCAAAAC
CTTTTCATGGGTGAAAATCAATTCAATGTACCCAAGGAGCCTGAGATTGTGACTTTCAAT
ACCACCTTTGGAAGTTTTGGCATTTTCACATGCTTTGATATACTCTTCCATGATCCTGCT
GTTACCTTGGTGAAAGATTTCCACGTGGACACCATAGTATTCCCAACAGCTTGGATGAAT
GTTTTGCCACATTTGTCAGCTGTTGAATTCCACTCAGCTTGGGCTATGGGCATGAGGGTC
AATTTCCTTGCATCCAACATACATTACCCCTCAAAGAAAATGACAGGAAGTGGCATCTAT
GCACCCAATTCTTCAAGAGCATTTCATTATGATATGAAGACAGAAGAGGGAAAACTCCTC
CTCTCGCAACTGGATTCCCACCCATCCCATTCTGCAGTGGTGAACTGGACTTCCTATGCC
AGCAGTATAGAAGCGCTCTCATCAGGAAACAAGGAATTTAAAGGCACTGTCTTTTTCGAT
GAATTCACTTTTGTGAAGCTCACAGGAGTTGCAGGAAATTATACAGTTTGTCAGAAAGAT
CTCTGCTGTCATTTAAGCTACAAAATGTCTGAGAACATACCAAATGAAGTGTACGCTCTA
GGGGCATTTGACGGACTGCACACTGTGGAAGGGCGCTATTATCTACAGATTTGTACCCTG
TTGAAATGTAAAACGACTAATTTAAACACTTGCGGTGACTCAGCTGAAACAGCTTCTACC
AGGTTTGAAATGTTCTCCCTCAGTGGCACTTTCGGAACCCAGTATGTCTTTCCTGAGGTG
TTGCTGAGTGAAAATCAGCTTGCACCTGGAGAATTTCAGGTGTCAACTGACGGACGCTTG
TTTAGTCTGAAGCCAACATCCGGACCTGTCTTAACAGTAACTCTGTTTGGGAGGTTGTAT
GAGAAGGACTGGGCATCAAATGCTTCATCAGGCCTCACAGCACAAGCAAGAATAATAATG
CTAATAGTTATAGCACCTATTGTATGCTCATTAAGTTGGTAG
|
Protein Properties |
Number of Residues
| 513 |
Molecular Weight
| 57011.16 |
Theoretical pI
| 5.554 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Pantetheinase
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDIL
EGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPV
QERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQN
LFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMN
VLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLL
LSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKD
LCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETAST
RFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLY
EKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
|
External Links |
GenBank ID Protein
| 4128047 |
UniProtKB/Swiss-Prot ID
| O95497 |
UniProtKB/Swiss-Prot Entry Name
| VNN1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AJ132099 |
GeneCard ID
| VNN1 |
GenAtlas ID
| VNN1 |
HGNC ID
| HGNC:12705 |
References |
General References
| Not Available |