| Identification |
|---|
| HMDB Protein ID
| CDBP01687 |
| Secondary Accession Numbers
| Not Available |
| Name
| Pantetheinase |
| Description
| Not Available |
| Synonyms
|
- Pantetheine hydrolase
- Tiff66
- Vanin-1
- Vascular non-inflammatory molecule 1
|
| Gene Name
| VNN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| Specific Function
| Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
|
| GO Classification
|
| Biological Process |
| acute inflammatory response |
| negative regulation of apoptotic process |
| cellular component movement |
| response to oxidative stress |
| pantothenate metabolic process |
| innate immune response |
| cell-cell adhesion |
| chronic inflammatory response |
| positive regulation of T cell differentiation in thymus |
| Cellular Component |
| anchored to membrane |
| plasma membrane |
| integral to membrane |
| Function |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| GPI anchor binding |
| pantetheine hydrolase activity |
| Process |
| metabolic process |
| nitrogen compound metabolic process |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pantothenate and CoA Biosynthesis |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q23-q24 |
| SNPs
| VNN1 |
| Gene Sequence
|
>1542 bp
ATGACTACTCAGTTGCCAGCTTACGTGGCAATTTTGCTTTTCTATGTCTCAAGAGCCAGC
TGCCAGGACACTTTCATTGCAGCTGTTTATGAGCATGCAGCGATATTGCCCAATGCCACC
CTAACACCAGTGTCTCGTGAGGAGGCTTTGGCATTAATGAATCGGAATCTGGACATTTTG
GAAGGAGCGATCACATCAGCAGCAGATCAGGGTGCGCATATTATTGTGACTCCAGAAGAT
GCTATTTATGGCTGGAACTTCAACAGGGACTCTCTCTACCCATATTTGGAGGACATCCCA
GACCCTGAAGTAAACTGGATCCCCTGTAATAATCGTAACAGATTTGGCCAGACCCCAGTA
CAAGAAAGACTCAGCTGCCTGGCCAAGAACAACTCTATCTATGTTGTGGCAAATATTGGG
GACAAGAAGCCATGCGATACCAGTGATCCTCAGTGTCCCCCTGATGGCCGTTACCAATAC
AACACTGATGTGGTATTTGATTCTCAAGGAAAACTGGTGGCACGCTACCATAAGCAAAAC
CTTTTCATGGGTGAAAATCAATTCAATGTACCCAAGGAGCCTGAGATTGTGACTTTCAAT
ACCACCTTTGGAAGTTTTGGCATTTTCACATGCTTTGATATACTCTTCCATGATCCTGCT
GTTACCTTGGTGAAAGATTTCCACGTGGACACCATAGTATTCCCAACAGCTTGGATGAAT
GTTTTGCCACATTTGTCAGCTGTTGAATTCCACTCAGCTTGGGCTATGGGCATGAGGGTC
AATTTCCTTGCATCCAACATACATTACCCCTCAAAGAAAATGACAGGAAGTGGCATCTAT
GCACCCAATTCTTCAAGAGCATTTCATTATGATATGAAGACAGAAGAGGGAAAACTCCTC
CTCTCGCAACTGGATTCCCACCCATCCCATTCTGCAGTGGTGAACTGGACTTCCTATGCC
AGCAGTATAGAAGCGCTCTCATCAGGAAACAAGGAATTTAAAGGCACTGTCTTTTTCGAT
GAATTCACTTTTGTGAAGCTCACAGGAGTTGCAGGAAATTATACAGTTTGTCAGAAAGAT
CTCTGCTGTCATTTAAGCTACAAAATGTCTGAGAACATACCAAATGAAGTGTACGCTCTA
GGGGCATTTGACGGACTGCACACTGTGGAAGGGCGCTATTATCTACAGATTTGTACCCTG
TTGAAATGTAAAACGACTAATTTAAACACTTGCGGTGACTCAGCTGAAACAGCTTCTACC
AGGTTTGAAATGTTCTCCCTCAGTGGCACTTTCGGAACCCAGTATGTCTTTCCTGAGGTG
TTGCTGAGTGAAAATCAGCTTGCACCTGGAGAATTTCAGGTGTCAACTGACGGACGCTTG
TTTAGTCTGAAGCCAACATCCGGACCTGTCTTAACAGTAACTCTGTTTGGGAGGTTGTAT
GAGAAGGACTGGGCATCAAATGCTTCATCAGGCCTCACAGCACAAGCAAGAATAATAATG
CTAATAGTTATAGCACCTATTGTATGCTCATTAAGTTGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 513 |
| Molecular Weight
| 57011.16 |
| Theoretical pI
| 5.554 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pantetheinase
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDIL
EGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPV
QERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQN
LFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMN
VLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLL
LSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKD
LCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETAST
RFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLY
EKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
|
| External Links |
|---|
| GenBank ID Protein
| 4128047 |
| UniProtKB/Swiss-Prot ID
| O95497 |
| UniProtKB/Swiss-Prot Entry Name
| VNN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ132099 |
| GeneCard ID
| VNN1 |
| GenAtlas ID
| VNN1 |
| HGNC ID
| HGNC:12705 |
| References |
|---|
| General References
| Not Available |