Showing Protein Endothelial differentiation-related factor 1 (CDBP01657)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP01657
Secondary Accession Numbers Not Available
Name Endothelial differentiation-related factor 1
Description Not Available
Synonyms
  1. EDF-1
  2. MBF1
  3. Multiprotein-bridging factor 1
Gene Name EDF1
Protein Type Enzyme
Biological Properties
General Function Involved in sequence-specific DNA binding
Specific Function Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism
GO Classification
Function
binding
nucleic acid binding
dna binding
sequence-specific dna binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:9
Locus 9q34.3
SNPs EDF1
Gene Sequence 
>447 bp
ATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCC
CAGGCCAAATCCAAGCAGGCTATCTTAGCGGCACAGAGACGAGGAGAAGATGTGGAGACT
TCCAAGAAATGGGCTGCTGGCCAGAACAAACAACATTCTATTACCAAGAACACGGCCAAG
CTGGACCGGGAGACAGAGGAGCTGCACCATGACAGGGTGACCCTGGAGGTGGGCAAGGTG
ATCCAGCAAGGTCGGCAGAGCAAGGGGCTTACGCAGAAGGACCTGGCCACGAAAATCAAT
GAGAAGCCACAGGTGATCGCGGACTATGAGAGCGGACGGGCCATACCCAATAACCAGGTG
CTTGGCAAAATCGAGCGGGCCATTGGCCTCAAGCTCCGGGGAAAGGACATTGGAAAGCCC
ATCGAGAAGGGGCCTAGGGCGAAATGA
Protein Properties
Number of Residues 148
Molecular Weight 16368.6
Theoretical pI 10.72
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Endothelial differentiation-related factor 1
MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAK
LDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQV
LGKIERAIGLKLRGKDIGKPIEKGPRAK
GenBank ID Protein 6526355
UniProtKB/Swiss-Prot ID O60869
UniProtKB/Swiss-Prot Entry Name EDF1_HUMAN
PDB IDs Not Available
GenBank Gene ID AB002282
GeneCard ID EDF1
GenAtlas ID EDF1
HGNC ID HGNC:3164
References
General References Not Available