Cannabis Compound Database: Showing Protein Type II inositol 1,4,5-trisphosphate 5-phosphatase (CDBP01649)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP01649

Secondary Accession Numbers

Not Available

Name

Type II inositol 1,4,5-trisphosphate 5-phosphatase

Description

Not Available

Synonyms

5PTase
75 kDa inositol polyphosphate-5-phosphatase
Phosphoinositide 5-phosphatase

Gene Name

INPP5B

Protein Type

Enzyme

Biological Properties

General Function

Involved in inositol or phosphatidylinositol phosphatase activity

Specific Function

Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.

GO Classification

Biological Process
phosphatidylinositol phosphorylation
small GTPase mediated signal transduction
spermatogenesis
phosphatidylinositol dephosphorylation
regulation of protein processing
regulation of small GTPase mediated signal transduction
sperm motility
Cellular Component
cytosol
microtubule cytoskeleton
Golgi apparatus
early endosome membrane
phagocytic vesicle membrane
endoplasmic reticulum-Golgi intermediate compartment
membrane
integral to membrane
Component
cell part
intracellular
Function
phosphatase activity
inositol or phosphatidylinositol phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
Molecular Function
metal ion binding
inositol-1,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction

Cellular Location

Cytoplasmic

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phosphatidylinositol signaling system	Not Available

Gene Properties

Chromosome Location

Locus

1p34

SNPs

INPP5B

Gene Sequence

>2982 bp
ATGGACCAGTCTGTGGCAATCCAGGAGACGCTGGCTGAGGGGGAATACTGCGTCATCGCG
GTGCAAGGTGTGCTGTGTGAGGGGGACAGCCGGCAGAGCCGCCTCCTGGGACTCGTGCGC
TACCGCCTGGAGCACGGCGGCCAGGAACACGCTCTCTTCCTCTATACGCACCGGAGGATG
GCCATTACCGGGGACGATGTCTCTCTGGACCAGATAGTGCCAGTCTCGCGGGATTTTACG
CTGGAAGAAGTGTCCCCAGATGGTGAACTCTACATCCTTGGCTCAGATGTGACCGTCCAG
CTGGACACAGCAGAGCTTAGCCTCGTATTCCAACTGCCCTTTGGTTCACAAACCAGGATG
TTCCTCCACGAAGTTGCCAGGGCCTGTCCAGGCTTCGATTCTGCGACCCGGGATCCTGAA
TTCCTGTGGCTGTCTCGGTATAGGTGCGCAGAGCTGGAGCTGGAGATGCCAACGCCGCGC
GGTTGTAACTCGGCCCTAGTTACCTGGCCAGGGTACGCGACAATTGGCGGAGGCAGGTAT
CCGTCCCGGAAGAAACGGTGGGGATTGGAGGAGGCCCGGCCACAGGGGGCGGGCTCCGTT
CTGTTTTGGGGCGGAGCGATGGAGAAGACAGGCTTTCGATTGATGGAGCGGGCACACGGG
GGCGGGTTCGTCTGGGGGCGGAGCGCGCGGGACGGGCGGCGGGATGAGGAGCTTGAGGAA
GCAGGCAGGGAAATGTCTGCCGCCGCCGGCTCTCGGGAGCGCAACACTGCAGGTGGTTCT
AACTTTGATGGTTTGAGACCAAATGGGAAGGGAGTGCCTATGGACCAAAGCTCCAGGGGT
CAAGATAAACCAGAAAGCTTGCAACCAAGACAGAATAAATCCAAGTCCGAAATTACTGAC
ATGGTTCGCTCCTCCACTATCACAGTGTCGGACAAGGCTCATATTTTATCCATGCAGAAG
TTTGGACTGCGAGATACAATTGTGAAATCACATCTACTACAGAAAGAAGAGGATTACACC
TATATCCAGAACTTCAGGTTTTTTGCGGGAACATACAATGTAAATGGGCAGTCCCCCAAA
GAATGCCTCCGGCTGTGGCTGAGCAATGGTATCCAGGCCCCAGATGTCTATTGTGTAGGG
TTCCAGGAGCTTGATCTGAGTAAGGAAGCTTTTTTCTTTCACGATACCCCAAAGGAGGAA
GAGTGGTTCAAAGCTGTGTCAGAGGGTCTTCATCCAGATGCCAAATATGCAAAGGTGAAG
CTTATCCGACTGGTTGGGATTATGCTGCTGTTATATGTCAAACAGGAGCATGCAGCTTAT
ATCTCAGAAGTGGAAGCCGAGACTGTGGGGACAGGAATCATGGGGAGGATGGGCAACAAG
GGAGGCGTGGCGATCAGGTTCCAGTTCCACAACACCAGCATCTGCGTTGTGAATTCTCAC
TTGGCAGCCCACATTGAAGAGTATGAGAGGAGGAACCAGGACTATAAGGACATTTGTTCT
CGAATGCAGTTTTGTCAGCCTGACCCAAGCCTTCCCCCTCTCACCATCAGCAACCATGAT
GTGATCTTGTGGCTGGGGGACCTCAACTACAGGATAGAAGAGCTGGATGTGGAAAAAGTG
AAAAAGCTCATCGAAGAGAAGGACTTTCAAATGCTGTATGCATATGATCAGCTGAAAATT
CAGGTGGCCGCAAAGACTGTCTTTGAAGGCTTCACAGAGGGTGAGCTCACATTCCAGCCT
ACTTACAAGTATGATACGGGCTCTGACGACTGGGATACCAGTGAGAAGTGCCGTGCTCCT
GCCTGGTGTGATCGGATTCTCTGGAAAGGGAAGAACATCACTCAGCTGAGTTACCAGAGC
CACATGGCCCTGAAGACCAGTGACCACAAGCCTGTCAGCTCAGTGTTTGACATCGGGGTG
AGGGTCGTAAATGACGAGCTTTACCGGAAGACACTGGAGGAAATTGTTCGCTCCCTGGAT
AAGATGGAAAATGCCAACATTCCTTCTGTGTCCCTGTCCAAGCGAGAGTTCTGTTTTCAG
AATGTGAAGTACATGCAATTGAAAGTAGAATCCTTTACAATTCATAATGGACAAGTACCC
TGTCATTTTGAATTCATCAACAAGCCTGATGAAGAGTCTTACTGTAAGCAGTGGCTGAAT
GCCAACCCCAGCAGAGGCTTCCTCCTGCCAGATTCTGATGTTGAGATTGACTTGGAGCTC
TTCGTAAATAAGATGACAGCTACAAAGCTCAACTCGGGTGAAGACAAAATTGAGGACATT
CTGGTTCTGCACTTGGACAGGGGAAAGGATTACTTTTTGTCTGTGTCTGGGAACTACCTG
CCCAGCTGTTTTGGGTCTCCCATTCATACACTGTGTTACATGAGAGAGCCAATCTTGGAC
CTACCACTTGAAACCATTAGTGAGCTGACTCTGATGCCAGTATGGACTGGAGATGATGGG
AGCCAGTTGGATAGCCCCATGGAAATCCCCAAAGAGCTCTGGATGATGGTTGATTACCTG
TACCGAAATGCTGTCCAGCAGGAAGATCTGTTTCAGCAACCAGGCCTGAGGTCAGAATTT
GAACATATCAGGGACTGCTTGGATACTGGAATGATTGATAACCTCTCTGCCAGCAATCAT
TCTGTAGCCGAAGCCCTGCTGCTTTTCCTGGAGAGCCTTCCAGAGCCTGTCATCTGTTAC
AGCACCTACCATAACTGCTTGGAGTGTTCTGGCAACTACACAGCAAGCAAACAGGTCATT
TCTACTCTCCCCATATTCCACAAAAATGTCTTCCACTACTTGATGGCGTTTTTGCGAGAA
CTGCTGAAAAATTCAGCAAAAAATCATTTGGATGAGAATATTCTAGCTAGCATATTTGGC
AGCTTATTGCTTCGAAACCCAGCTGGTCACCAAAAGCTTGATATGACAGAGAAGAAGAAG
GCTCAAGAATTTATTCACCAGTTCCTCTGCAACCCACTCTGA

Protein Properties

Number of Residues

993

Molecular Weight

103986.41

Theoretical pI

5.357

Pfam Domain Function

Exo_endo_phos (PF03372 )
RhoGAP (PF00620 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Type II inositol-1,4,5-trisphosphate 5-phosphatase
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRM
AITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRM
FLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRY
PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEE
AGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITD
MVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVK
LIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSH
LAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKV
KKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAP
AWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLD
KMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLN
ANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYL
PSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYL
YRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICY
STYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFG
SLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL

External Links

GenBank ID Protein

55665969

UniProtKB/Swiss-Prot ID

P32019

UniProtKB/Swiss-Prot Entry Name

I5P2_HUMAN

PDB IDs