Identification |
HMDB Protein ID
| CDBP01639 |
Secondary Accession Numbers
| Not Available |
Name
| Sodium/nucleoside cotransporter 1 |
Description
| Not Available |
Synonyms
|
- CNT 1
- Concentrative nucleoside transporter 1
- Na(+)/nucleoside cotransporter 1
- Sodium-coupled nucleoside transporter 1
- Solute carrier family 28 member 1
- hCNT1
|
Gene Name
| SLC28A1 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in nucleoside:sodium symporter activity |
Specific Function
| Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.
|
GO Classification
|
Biological Process |
nucleoside transport |
pyrimidine-containing compound transmembrane transport |
nucleobase-containing compound metabolic process |
Cellular Component |
apical plasma membrane |
integral to plasma membrane |
Component |
membrane |
cell part |
Function |
binding |
nucleoside binding |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity |
nucleoside transmembrane transporter activity |
nucleoside:sodium symporter activity |
transporter activity |
Molecular Function |
nucleoside binding |
nucleoside transmembrane transporter activity |
pyrimidine- and adenine-specific:sodium symporter activity |
Process |
transport |
establishment of localization |
|
Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Gemcitabine Action Pathway | | Not Available | Gemcitabine Metabolism Pathway | | Not Available | Capecitabine Action Pathway | | Not Available | Capecitabine Metabolism Pathway | | Not Available |
|
Gene Properties |
Chromosome Location
| 15 |
Locus
| 15q25.3 |
SNPs
| SLC28A1 |
Gene Sequence
|
>1950 bp
ATGGAGAACGACCCCTCGAGACGAAGAGAGTCCATCTCTCTCACACCTGTGGCCAAGGGT
CTGGAGAACATGGGGGCTGATTTCTTGGAAAGCCTGGAGGAAGGCCAGCTCCCTAGGAGT
GACTTGAGCCCCGCAGAGATCAGGAGCAGCTGGAGCGAGGCGGCGCCGAAGCCCTTCTCC
AGATGGAGGAACCTGCAGCCAGCCCTGAGAGCCAGAAGCTTCTGCAGGGAGCACATGCAG
CTGTTTCGATGGATCGGCACAGGCCTGCTCTGCACTGGGCTCTCTGCCTTCCTGCTGGTG
GCCTGCCTCCTGGATTTCCAGAGGGCCCTGGCTCTGTTTGTCCTCACCTGTGTGGTCCTC
ACCTTCCTGGGCCACCGCCTGCTGAAACGGCTTCTGGGGCCAAAGCTGAGGAGGTTTCTC
AAGCCTCAGGGCCATCCCCGCCTGCTGCTCTGGTTTAAGAGGGGTCTAGCTCTTGCTGCT
TTCCTGGGCCTGGTCCTGTGGCTGTCTCTGGACACCTCCCAGCGGCCTGAGCAACTGGTG
TCCTTCGCAGGAATCTGCGTGTTCGTCGCTCTCCTCTTTGCCTGCTCAAAGCATCATTGC
GCAGTGTCCTGGAGGGCCGTGTCTTGGGGACTTGGACTGCAGTTTGTACTTGGACTCCTC
GTCATCAGAACAGAACCAGGATTCATTGCGTTCGAGTGGCTGGGCGAGCAGATCCGGATC
TTCCTGAGCTACACGAAGGCTGGCTCCAGCTTCGTGTTTGGGGAGGCGCTGGTCAAGGAT
GTCTTTGCCTTTCAGGTTCTGCCCATCATTGTCTTTTTCAGCTGTGTCATATCCGTTCTC
TACCACGTGGGCCTCATGCAGTGGGTGATCCTGAAGATTGCCTGGCTGATGCAAGTCACC
ATGGGCACCACAGCCACTGAGACCCTGAGTGTGGCTGGAAACATCTTTGTGAGCCAGACC
GAGGCTCCATTACTGATCCGGCCCTACTTGGCAGACATGACACTCTCTGAAGTCCACGTT
GTCATGACCGGAGGTTACGCCACCATTGCTGGCAGCCTGCTGGGTGCCTACATCTCCTTT
GGGATCGATGCCACCTCGTTGATTGCAGCCTCTGTGATGGCTGCCCCTTGTGCCTTGGCC
CTCTCCAAGCTGGTCTACCCGGAGGTGGAGGAGTCCAAGTTTAGGAGGGAGGAAGGAGTG
AAACTGACCTATGGAGATGCTCAGAACCTCATAGAAGCAGCCAGCACTGGGGCCGCCATC
TCCGTGAAGGTGGTCGCCAACATCGCTGCCAACCTGATTGCGTTCCTGGCTGTGCTGGAC
TTTATCAATGCTGCCCTCTCCTGGCTGGGAGACATGGTGGACATCCAGGGGCTCAGCTTC
CAGCTCATCTGCTCCTACATCCTGCGGCCTGTAGCCTTCTTGATGGGTGTGGCGTGGGAG
GACTGCCCAGTGGTAGCTGAGCTGCTGGGGATCAAGCTGTTTCTGAACGAGTTTGTGGCC
TATCAAGACCTCTCCAAGTACAAGCAACGCCGCCTGGCAGGGGCCGAGGAGTGGGTCGGC
GACAGGAAGCAGTGGATCTCCGTCAGAGCTGAAGTCCTCACGACGTTTGCCCTCTGTGGA
TTTGCCAATTTCAGCTCCATTGGGATCATGCTGGGAGGCTTGACCTCCATGGTCCCCCAA
CGGAAGAGCGACTTCTCCCAGATAGTGCTCCGGGCGCTCTTCACGGGAGCCTGTGTGTCC
CTGGTGAACGCCTGTATGGCAGGGATCCTCTACATGCCCAGGGGGGCTGAAGTTGACTGC
ATGTCCCTCTTGAACACGACCCTCAGCAGCAGTAGCTTTGAGATTTACCAGTGCTGCCGT
GAGGCCTTCCAGAGCGTCAATCCAGAGTTCAGCCCAGAGGCCCTGGACAACTGCTGTCGG
TTTTACAACCACACGATCTGTGCACAGTGA
|
Protein Properties |
Number of Residues
| 649 |
Molecular Weight
| 71583.18 |
Theoretical pI
| 7.596 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Sodium/nucleoside cotransporter 1
MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFS
RWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVL
TFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLV
SFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRI
FLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVT
MGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISF
GIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAI
SVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWE
DCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCG
FANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDC
MSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ
|
External Links |
GenBank ID Protein
| 42542381 |
UniProtKB/Swiss-Prot ID
| O00337 |
UniProtKB/Swiss-Prot Entry Name
| S28A1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_004213.3 |
GeneCard ID
| SLC28A1 |
GenAtlas ID
| SLC28A1 |
HGNC ID
| HGNC:11001 |
References |
General References
| Not Available |