Identification |
HMDB Protein ID
| CDBP01625 |
Secondary Accession Numbers
| Not Available |
Name
| B(0,+)-type amino acid transporter 1 |
Description
| Not Available |
Synonyms
|
- B(0,+)AT
- Glycoprotein-associated amino acid transporter b0,+AT1
- Solute carrier family 7 member 9
|
Gene Name
| SLC7A9 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in transport |
Specific Function
| Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule |
GO Classification
|
Component |
membrane |
cell part |
Function |
active transmembrane transporter activity |
transmembrane transporter activity |
amine transmembrane transporter activity |
amino acid transmembrane transporter activity |
transporter activity |
Process |
amino acid transport |
transmembrane transport |
establishment of localization |
transport |
amine transport |
|
Cellular Location
|
- Membrane
- Multi-pass membrane protein (Probable)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Kidney Function | | Not Available | Glucose Transporter Defect (SGLT2) | | Not Available | Hartnup Disorder | | Not Available | Iminoglycinuria | | Not Available | Lysinuric Protein Intolerance | | Not Available |
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 19q13.1 |
SNPs
| SLC7A9 |
Gene Sequence
|
>1464 bp
ATGGGGGATACTGGCCTGAGAAAGCGGAGAGAGGATGAGAAGTCGATCCAGAGCCAAGAG
CCTAAGACCACCAGTCTCCAAAAGGAGCTGGGCCTCATCAGTGGCATCTCCATCATCGTG
GGCACCATCATTGGCTCTGGGATCTTCGTTTCCCCCAAGTCTGTGCTCAGCAACACGGAA
GCTGTGGGGCCCTGCCTCATCATATGGGCGGCTTGCGGGGTCCTCGCGACGCTGGGTGCC
CTGTGCTTTGCGGAGCTTGGCACAATGATCACCAAGTCAGGGGGAGAGTATCCCTACCTG
ATGGAGGCCTACGGGCCCATCCCCGCCTACCTCTTCTCCTGGGCCAGCCTGATCGTCATT
AAGCCCACGTCCTTCGCCATCATCTGCCTCAGCTTCTCCGAGTATGTGTGTGCGCCCTTC
TATGTGGGCTGCAAGCCTCCTCAAATCGTTGTGAAATGCCTGGCCGCCGCCGCCATCTTG
TTCATCTCGACAGTGAACTCACTGAGCGTGCGGCTGGGAAGCTACGTCCAGAACATCTTC
ACCGCGGCCAAGCTGGTGATCGTGGCCATCATCATCATCAGCGGGCTGGTGCTCCTGGCC
CAAGGAAACACAAAGAATTTTGATAATTCTTTCGAGGGCGCCCAGCTGTCTGTGGGAGCC
ATCAGCCTGGCGTTTTACAATGGACTCTGGGCCTATGATGGATGGAATCAACTCAATTAC
ATCACAGAAGAACTTAGAAACCCTTACAGAAACCTGCCTTTGGCCATTATCATCGGGATC
CCCCTGGTGACGGCGTGCTACATCCTCATGAACGTGTCCTACTTCACCGTGATGACTGCC
ACCGAACTCCTGCAGTCCCAGGCGGTGGCTGTGACATTTGGTGACCGTGTTCTCTATCCT
GCTTCTTGGATCGTTCCACTTTTTGTGGCATTTTCAACCATCGGTGCTGCTAACGGGACC
TGCTTCACAGCGGGCAGACTCATTTACGTGGCGGGCCGGGAGGGTCACATGCTCAAAGTG
CTTTCTTACATCAGCGTCAGGCGCCTCACTCCAGCCCCCGCCATCATCTTTTATGGTATC
ATAGCAACGATTTATATCATCCCTGGTGACATAAACTCGTTAGTCAATTATTTCAGCTTT
GCTGCATGGCTGTTTTATGGCCTGACGATTCTAGGACTCATCGTGATGAGATTTACAAGG
AAAGAGCTGGAAAGGCCTATCAAGGTGCCCGTAGTCATTCCCGTCTTGATGACACTCATC
TCTGTGTTTTTGGTTCTGGCTCCAATCATCAGCAAGCCCACCTGGGAGTACCTCTACTGT
GTGCTGTTTATATTAAGCGGCCTTTTATTTTACTTCCTGTTTGTCCACTACAAGTTTGGA
TGGGCTCAGAAAATCTCAAAGCCGATTACCATGCACCTTCAGATGCTAATGGAAGTGGTC
CCACCGGAGGAAGACCCTGAGTAA
|
Protein Properties |
Number of Residues
| 487 |
Molecular Weight
| 53480.8 |
Theoretical pI
| 8.21 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["30-50", "61-81", "100-120", "149-169", "179-199", "211-231", "252-272", "297-317", "349-369", "375-395", "410-430", "435-455"]
|
Protein Sequence
|
>B(0,+)-type amino acid transporter 1
MGDTGLRKRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTE
AVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVI
KPTSFAIICLSFSEYVCAPFYVGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIF
TAAKLVIVAIIIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNGLWAYDGWNQLNY
ITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYP
ASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGI
IATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLMTLI
SVFLVLAPIISKPTWEYLYCVLFILSGLLFYFLFVHYKFGWAQKISKPITMHLQMLMEVV
PPEEDPE
|
External Links |
GenBank ID Protein
| 5916108 |
UniProtKB/Swiss-Prot ID
| P82251 |
UniProtKB/Swiss-Prot Entry Name
| BAT1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF141289 |
GeneCard ID
| SLC7A9 |
GenAtlas ID
| SLC7A9 |
HGNC ID
| HGNC:11067 |
References |
General References
| Not Available |