| Identification |
|---|
| HMDB Protein ID
| CDBP01623 |
| Secondary Accession Numbers
| Not Available |
| Name
| Angiogenin |
| Description
| Not Available |
| Synonyms
|
- RNase 5
- Ribonuclease 5
|
| Gene Name
| ANG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleic acid binding |
| Specific Function
| May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| binding |
| catalytic activity |
| hydrolase activity |
| nucleic acid binding |
| nuclease activity |
| endonuclease activity |
| endoribonuclease activity |
| endoribonuclease activity, producing 3'-phosphomonoesters |
| pancreatic ribonuclease activity |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q11.1-q11.2 |
| SNPs
| ANG |
| Gene Sequence
|
>444 bp
ATGGTGATGGGCCTGGGCGTTTTGTTGTTGGTCTTCGTGCTGGGTCTGGGTCTGACCCCA
CCGACCCTGGCTCAGGATAACTCCAGGTACACACACTTCCTGACCCAGCACTATGATGCC
AAACCACAGGGCCGGGATGACAGATACTGTGAAAGCATCATGAGGAGACGGGGCCTGACC
TCACCCTGCAAAGACATCAACACATTTATTCATGGCAACAAGCGCAGCATCAAGGCCATC
TGTGAAAACAAGAATGGAAACCCTCACAGAGAAAACCTAAGAATAAGCAAGTCTTCTTTC
CAGGTCACCACTTGCAAGCTACATGGAGGTTCCCCCTGGCCTCCATGCCAGTACCGAGCC
ACAGCGGGGTTCAGAAACGTTGTTGTTGCTTGTGAAAATGGCTTACCTGTCCACTTGGAT
CAGTCAATTTTCCGTCGTCCGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 147 |
| Molecular Weight
| 16549.9 |
| Theoretical pI
| 10.09 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Angiogenin
MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQGRDDRYCESIMRRRGLT
SPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQVTTCKLHGGSPWPPCQYRA
TAGFRNVVVACENGLPVHLDQSIFRRP
|
| External Links |
|---|
| GenBank ID Protein
| 33392770 |
| UniProtKB/Swiss-Prot ID
| P03950 |
| UniProtKB/Swiss-Prot Entry Name
| ANGI_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC054880 |
| GeneCard ID
| ANG |
| GenAtlas ID
| ANG |
| HGNC ID
| HGNC:483 |
| References |
|---|
| General References
| Not Available |