| Identification |
|---|
| HMDB Protein ID
| CDBP01617 |
| Secondary Accession Numbers
| Not Available |
| Name
| Centromere protein R |
| Description
| Not Available |
| Synonyms
|
- Beta-3-endonexin
- CENP-R
- Integrin beta-3-binding protein
- Nuclear receptor-interacting factor 3
|
| Gene Name
| ITGB3BP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein C-terminus binding |
| Specific Function
| Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Isoform 4:Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p31.3 |
| SNPs
| ITGB3BP |
| Gene Sequence
|
>534 bp
ATGCCTGTTAAAAGATCACTGAAGTTGGATGGTCTGTTAGAAGAAAATTCATTTGATCCT
TCAAAAATCACAAGGAAGAAAAGTGTTATAACTTATTCTCCAACAACTGGAACTTGTCAA
ATGAGTCTATTTGCTTCTCCCACAAGTTCTGAAGAGCAAAAGCACAGAAATGGACTATCA
AATGAAAAGAGAAAAAAATTGAATCACCCCAGTTTAACTGAAAGCAAAGAATCTACAACA
AAAGACAATGATGAATTCATGATGTTGCTATCAAAAGTTGAGAAATTGTCAGAAGAAATC
ATGGAGATAATGCAAAATTTAAGTAGTATACAGGCTTTGGAGGGCAGTAGAGAGCTTGAA
AATCTCATTGGAATCTCCTGTGCATCACATTTCTTAAAAAGAGAAATGCAGAAAACCAAA
GAACTAATGACAAAAGTGAATAAACAAAAACTGTTTGAAAAGAGTACAGGACTTCCTCAC
AAAGCATCACGTCATCTTGACAGCTATGAATTCCTTAAAGCCATTTTAAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 177 |
| Molecular Weight
| 20194.0 |
| Theoretical pI
| 9.7 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Centromere protein R
MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLS
NEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELE
NLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN
|
| External Links |
|---|
| GenBank ID Protein
| 6002985 |
| UniProtKB/Swiss-Prot ID
| Q13352 |
| UniProtKB/Swiss-Prot Entry Name
| CENPR_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF175306 |
| GeneCard ID
| ITGB3BP |
| GenAtlas ID
| ITGB3BP |
| HGNC ID
| HGNC:6157 |
| References |
|---|
| General References
| Not Available |