Identification |
HMDB Protein ID
| CDBP01604 |
Secondary Accession Numbers
| Not Available |
Name
| Cell division control protein 42 homolog |
Description
| Not Available |
Synonyms
|
- G25K GTP-binding protein
|
Gene Name
| CDC42 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in GTP binding |
Specific Function
| Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Causes the formation of thin, actin-rich surface projections called filopodia |
GO Classification
|
Component |
cell part |
intracellular |
Function |
binding |
nucleotide binding |
guanyl nucleotide binding |
guanyl ribonucleotide binding |
gtp binding |
purine nucleotide binding |
Process |
biological regulation |
regulation of biological process |
regulation of cellular process |
signal transduction |
intracellular signal transduction |
small gtpase mediated signal transduction |
|
Cellular Location
|
- Cell membrane
- Lipid-anchor
- Cytoplasmic side (Potential)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | | Not Available | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | | Not Available |
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 1p36.1 |
SNPs
| CDC42 |
Gene Sequence
|
>576 bp
ATGCAGACAATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTG
ATATCCTACACAACAAACAAATTTCCATCGGAATATGTACCGACTGTTTTTGACAACTAT
GCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGG
CAAGAGGATTATGACAGATTACGACCGCTGAGTTATCCACAAACAGATGTATTTCTAGTC
TGTTTTTCAGTGGTCTCTCCATCTTCATTTGAAAACGTGAAAGAAAAGTGGGTGCCTGAG
ATAACTCACCACTGTCCAAAGACTCCTTTCTTGCTTGTTGGGACTCAAATTGATCTCAGA
GATGACCCCTCTACTATTGAGAAACTTGCCAAGAACAAACAGAAGCCTATCACTCCAGAG
ACTGCTGAAAAGCTGGCCCGTGACCTGAAGGCTGTCAAGTATGTGGAGTGTTCTGCACTT
ACACAGAGAGGTCTGAAGAATGTGTTTGATGAGGCTATCCTAGCTGCCCTCGAGCCTCCG
GAAACTCAACCCAAAAGGAAGTGCTGTATATTCTAA
|
Protein Properties |
Number of Residues
| 191 |
Molecular Weight
| 21310.4 |
Theoretical pI
| 5.83 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Cell division control protein 42 homolog
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP
ETQPKRKCCIF
|
External Links |
GenBank ID Protein
| 182857 |
UniProtKB/Swiss-Prot ID
| P60953 |
UniProtKB/Swiss-Prot Entry Name
| CDC42_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| M35543 |
GeneCard ID
| CDC42 |
GenAtlas ID
| CDC42 |
HGNC ID
| HGNC:1736 |
References |
General References
| Not Available |