Identification |
HMDB Protein ID
| CDBP01600 |
Secondary Accession Numbers
| Not Available |
Name
| Rho GDP-dissociation inhibitor 3 |
Description
| Not Available |
Synonyms
|
- Rho GDI 3
- Rho-GDI gamma
|
Gene Name
| ARHGDIG |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in Rho GDP-dissociation inhibitor activity |
Specific Function
| Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP |
GO Classification
|
Component |
cell part |
intracellular part |
cytoplasm |
Function |
small gtpase regulator activity |
enzyme regulator activity |
gdp-dissociation inhibitor activity |
rho gdp-dissociation inhibitor activity |
nucleoside-triphosphatase regulator activity |
gtpase regulator activity |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 16p13.3 |
SNPs
| ARHGDIG |
Gene Sequence
|
>678 bp
ATGCTGGGCCTGGACGCGTGCGAGCTGGGGGCGCAGCTGCTGGAGCTGCTCCGGCTGGCG
CTGTGCGCCCGAGTCCTCCTGGCTGACAAGGAGGGTGGGCCGCCGGCAGTGGACGAGGTG
TTGGATGAGGCTGTGCCCGAGTACCGGGCGCCGGGGAGGAAGAGCCTCTTGGAGATCCGG
CAGCTGGACCCGGACGACAGGAGCCTGGCCAAGTACAAGCGGGTGCTGCTGGGGCCCCTG
CCACCGGCCGTGGACCCAAGCCTGCCCAATGTGCAGGTGACCAGGCTGACACTCCTGTCG
GAACAGGCTCCGGGGCCCGTCGTCATGGATCTCACAGGGGACCTGGCTGTTCTGAAGGAC
CAGGTGTTTGTCCTGAAGGAAGGTGTTGATTACAGAGTGAAGATCTCCTTCAAGGTCCAC
AGGGAGATTGTCAGCGGCCTCAAGTGTCTGCACCACACCTACCGCCGGGGCCTGCGCGTG
GACAAGACCGTCTACATGGTGGGCAGCTATGGCCCGAGCGCCCAGGAGTATGAGTTTGTG
ACTCCGGTGGAGGAAGCGCCGAGGGGTGCGCTGGTGCGGGGCCCCTATCTGGTGGTGTCC
CTCTTCACCGACGATGACAGGACGCACCACCTGTCCTGGGAGTGGGGTCTCTGCATCTGC
CAGGACTGGAAGGACTGA
|
Protein Properties |
Number of Residues
| 225 |
Molecular Weight
| 25097.8 |
Theoretical pI
| 5.37 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Rho GDP-dissociation inhibitor 3
MLGLDACELGAQLLELLRLALCARVLLADKEGGPPAVDEVLDEAVPEYRAPGRKSLLEIR
QLDPDDRSLAKYKRVLLGPLPPAVDPSLPNVQVTRLTLLSEQAPGPVVMDLTGDLAVLKD
QVFVLKEGVDYRVKISFKVHREIVSGLKCLHHTYRRGLRVDKTVYMVGSYGPSAQEYEFV
TPVEEAPRGALVRGPYLVVSLFTDDDRTHHLSWEWGLCICQDWKD
|
External Links |
GenBank ID Protein
| 82941188 |
UniProtKB/Swiss-Prot ID
| Q99819 |
UniProtKB/Swiss-Prot Entry Name
| GDIR3_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB127078 |
GeneCard ID
| ARHGDIG |
GenAtlas ID
| ARHGDIG |
HGNC ID
| HGNC:680 |
References |
General References
| Not Available |