| Identification |
|---|
| HMDB Protein ID
| CDBP01578 |
| Secondary Accession Numbers
| Not Available |
| Name
| Gap junction alpha-1 protein |
| Description
| Not Available |
| Synonyms
|
- Connexin-43
- Cx43
- Gap junction 43 kDa heart protein
|
| Gene Name
| GJA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cell communication |
| Specific Function
| One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph |
| GO Classification
|
| Component |
| connexon complex |
| macromolecular complex |
| protein complex |
| Function |
| transmembrane transporter activity |
| transporter activity |
| Process |
| heart development |
| cell-cell signaling |
| cell communication |
| cellular process |
| developmental process |
| anatomical structure development |
| organ development |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- gap junction
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q21-q23.2 |
| SNPs
| GJA1 |
| Gene Sequence
|
>1149 bp
ATGGGTGACTGGAGCGCCTTAGGCAAACTCCTTGACAAGGTTCAAGCCTACTCAACTGCT
GGAGGGAAGGTGTGGCTGTCAGTACTTTTCATTTTCCGAATCCTGCTGCTGGGGACAGCG
GTTGAGTCAGCCTGGGGAGATGAGCAGTCTGCCTTTCGTTGTAACACTCAGCAACCTGGT
TGTGAAAATGTCTGCTATGACAAGTCTTTCCCAATCTCTCATGTGCGCTTCTGGGTCCTG
CAGATCATATTTGTGTCTGTACCCACACTCTTGTACCTGGCTCATGTGTTCTATGTGATG
CGAAAGGAAGAGAAACTGAACAAGAAAGAGGAAGAACTCAAGGTTGCCCAAACTGATGGT
GTCAATGTGGACATGCACTTGAAGCAGATTGAGATAAAGAAGTTCAAGTACGGTATTGAA
GAGCATGGTAAGGTGAAAATGCGAGGGGGGTTGCTGCGAACCTACATCATCAGTATCCTC
TTCAAGTCTATCTTTGAGGTGGCCTTCTTGCTGATCCAGTGGTACATCTATGGATTCAGC
TTGAGTGCTGTTTACACTTGCAAAAGAGATCCCTGCCCACATCAGGTGGACTGTTTCCTC
TCTCGCCCCACGGAGAAAACCATCTTCATCATCTTCATGCTGGTGGTGTCCTTGGTGTCC
CTGGCCTTGAATATCATTGAACTCTTCTATGTTTTCTTCAAGGGCGTTAAGGATCGGGTT
AAGGGAAAGAGCGACCCTTACCATGCGACCAGTGGTGCGCTGAGCCCTGCCAAAGACTGT
GGGTCTCAAAAATATGCTTATTTCAATGGCTGCTCCTCACCAACCGCTCCCCTCTCGCCT
ATGTCTCCTCCTGGGTACAAGCTGGTTACTGGCGACAGAAACAATTCTTCTTGCCGCAAT
TACAACAAGCAAGCAAGTGAGCAAAACTGGGCTAATTACAGTGCAGAACAAAATCGAATG
GGGCAGGCGGGAAGCACCATCTCTAACTCCCATGCACAGCCTTTTGATTTCCCCGATGAT
AACCAGAATTCTAAAAAACTAGCTGCTGGACATGAATTACAGCCACTAGCCATTGTGGAC
CAGCGACCTTCAAGCAGAGCCAGCAGTCGTGCCAGCAGCAGACCTCGGCCTGATGACCTG
GAGATCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 382 |
| Molecular Weight
| 43008.0 |
| Theoretical pI
| 8.98 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["14-36", "77-99", "155-177", "209-231"]
|
| Protein Sequence
|
>Gap junction alpha-1 protein
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG
CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG
VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS
LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRV
KGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRN
YNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVD
QRPSSRASSRASSRPRPDDLEI
|
| External Links |
|---|
| GenBank ID Protein
| 29917 |
| UniProtKB/Swiss-Prot ID
| P17302 |
| UniProtKB/Swiss-Prot Entry Name
| CXA1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X52947 |
| GeneCard ID
| GJA1 |
| GenAtlas ID
| GJA1 |
| HGNC ID
| HGNC:4274 |
| References |
|---|
| General References
| Not Available |