Showing Protein Protein lin-7 homolog A (CDBP01516)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP01516
Secondary Accession Numbers Not Available
Name Protein lin-7 homolog A
Description Not Available
Synonyms
  1. Lin-7A
  2. MALS-1
  3. Mammalian lin-seven protein 1
  4. TIP-33
  5. Tax interaction protein 33
  6. Veli-1
  7. Vertebrate lin-7 homolog 1
  8. hLin-7
Gene Name LIN7A
Protein Type Enzyme
Biological Properties
General Function Involved in exocytosis
Specific Function Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells
GO Classification
Function
binding
protein binding
Cellular Location
  1. Cell membrane
  2. Peripheral membrane protein
  3. Peripheral membrane protein
  4. Peripheral membrane protein
  5. Basolateral cell membrane
  6. Cell junction
  7. Cell junction
  8. Cell junction
  9. Cell junction
  10. synapse
  11. synapse
  12. tight junction
  13. postsynaptic cell membrane
  14. postsynaptic density
  15. synaptosome
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12q21
SNPs LIN7A
Gene Sequence 
>702 bp
ATGCTGAAGCCGAGCGTCACTTCGGCTCCCACGGCAGACATGGCGACATTGACAGTGGTC
CAGCCGCTCACCCTGGACAGAGATGTTGCAAGAGCAATTGAATTACTGGAAAAACTACAG
GAATCTGGAGAAGTACCAGTGCACAAGCTACAATCCCTCAAAAAAGTGCTTCAGAGTGAG
TTTTGTACAGCTATTCGAGAGGTGTATCAATATATGCATGAAACGATAACTGTTAATGGC
TGTCCCGAATTCCGTGCGAGGGCAACAGCAAAGGCAACAGTTGCAGCTTTTGCAGCTAGT
GAAGGCCACTCCCACCCTCGAGTAGTTGAACTGCCAAAGACTGATGAAGGCCTTGGTTTT
AATGTGATGGGAGGAAAGGAGCAAAATTCCCCCATTTATATCTCTCGCATAATTCCTGGA
GGGGTGGCTGAAAGACACGGAGGCCTCAAAAGAGGAGACCAGCTGCTATCAGTGAACGGA
GTGAGTGTGGAAGGAGAACACCATGAGAAAGCTGTGGAACTACTCAAGGCTGCTAAAGAC
AGCGTCAAGCTGGTGGTGCGATACACCCCAAAAGTTCTGGAAGAAATGGAGGCTCGCTTT
GAAAAGCTACGAACAGCCAGGCGTCGGCAGCAGCAGCAATTGCTAATTCAGCAGCAGCAA
CAGCAGCAGCAGCAACAAACACAACAAAACCACATGTCATAG
Protein Properties
Number of Residues 233
Molecular Weight 25996.6
Theoretical pI 9.1
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Protein lin-7 homolog A
MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSE
FCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGF
NVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKD
SVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS
GenBank ID Protein 4759306
UniProtKB/Swiss-Prot ID O14910
UniProtKB/Swiss-Prot Entry Name LIN7A_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_004664.2
GeneCard ID LIN7A
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available