Showing Protein Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (CDBP01490)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP01490
Secondary Accession Numbers Not Available
Name Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
Description Not Available
Synonyms
  1. Asparagine-linked glycosylation protein 3 homolog
  2. Dol-P-Man-dependent alpha(1-3)-mannosyltransferase
  3. Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
  4. Not56-like protein
  5. Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase
Gene Name ALG3
Protein Type Enzyme
Biological Properties
General Function Involved in transferase activity, transferring hexosyl groups
Specific Function Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.
GO Classification
Biological Process
dolichol-linked oligosaccharide biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Component
integral to membrane
cell part
membrane part
endoplasmic reticulum
intrinsic to membrane
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
alpha-1,3-mannosyltransferase activity
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein (Probable)
Pathways
Gene Properties
Chromosome Location 3
Locus 3q27.1
SNPs ALG3
Gene Sequence 
>1317 bp
ATGGCGGCTGGGCTGCGGAAACGCGGCCGGTCCGGTTCCGCGGCCCAGGCAGAGGGACTC
TGCAAGCAATGGCTGCAGCGCGCCTGGCAAGAGCGGCGCCTGCTGCTGCGGGAGCCGCGC
TACACGCTGCTGGTGGCCGCCTGCCTCTGCCTGGCGGAGGTGGGCATCACCTTCTGGGTC
ATTCACAGGGTGGCATACACAGAGATTGACTGGAAGGCCTACATGGCCGAGGTAGAAGGC
GTCATCAATGGTACCTATGACTATACCCAACTGCAGGGTGACACCGGACCACTTGTGTAC
CCAGCTGGTTTCGTGTACATCTTTATGGGGTTGTACTATGCCACCAGCCGAGGCACTGAC
ATCCGCATGGCCCAGAACATCTTTGCTGTGCTCTACCTGGCTACCTTGCTGCTTGTCTTC
TTGATCTATCACCAGACCTGCAAGGTACCTCCCTTCGTCTTTTTCTTCATGTGCTGCGCC
TCTTACCGTGTCCACTCCATCTTTGTGCTGCGGCTCTTCAATGACCCAGTGGCCATGGTG
CTGCTCTTCCTCAGTATCAACCTCCTGCTGGCCCAGCGCTGGGGCTGGGGTTGCTGCTTT
TTCAGCCTGGCAGTCTCTGTGAAGATGAATGTGCTGCTCTTCGCCCCTGGGTTACTGTTT
CTTCTCCTCACACAGTTTGGCTTCCGTGGGGCCCTCCCCAAGCTGGGAATCTGTGCTGGC
CTTCAGGTGGTGCTGGGGCTGCCCTTCCTGCTGGAGAACCCCAGCGGCTACCTGTCCCGC
TCCTTTGACCTTGGCCGCCAGTTTCTGTTCCACTGGACAGTGAACTGGCGCTTCCTCCCA
GAGGCGCTCTTCCTGCATCGAGCCTTCCACCTGGCCCTGTTGACTGCCCACCTCACCCTG
CTCCTGCTGTTTGCCCTCTGCAGGTGGCACAGGACAGGGGAAAGTATCTTGTCGCTGCTG
AGGGATCCCTCCAAAAGGAAGGTTCCACCCCAGCCCCTTACACCCAACCAGATCGTTTCT
ACCCTCTTCACCTCCAACTTCATTGGCATCTGCTTCAGCCGCTCCCTCCACTACCAGTTC
TACGTCTGGTATTTCCACACACTGCCCTACCTCCTGTGGGCCATGCCTGCACGCTGGCTC
ACACACCTGCTCAGGTTGTTGGTGCTGGGGCTCATCGAGCTCTCCTGGAACACATACCCT
TCCACATCCTGCAGCTCTGCTGCCCTGCACATATGCCATGCCGTCATCCTGCTGCAGCTC
TGGCTGGGCCCGCAGCCTTTCCCCAAGAGCACCCAACACAGCAAGAAAGCCCACTGA
Protein Properties
Number of Residues 438
Molecular Weight 44369.995
Theoretical pI 8.939
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase
MAAGLRKRGRSGSAAQAEGLCKQWLQRAWQERRLLLREPRYTLLVAACLCLAEVGITFWV
IHRVAYTEIDWKAYMAEVEGVINGTYDYTQLQGDTGPLVYPAGFVYIFMGLYYATSRGTD
IRMAQNIFAVLYLATLLLVFLIYHQTCKVPPFVFFFMCCASYRVHSIFVLRLFNDPVAMV
LLFLSINLLLAQRWGWGCCFFSLAVSVKMNVLLFAPGLLFLLLTQFGFRGALPKLGICAG
LQVVLGLPFLLENPSGYLSRSFDLGRQFLFHWTVNWRFLPEALFLHRAFHLALLTAHLTL
LLLFALCRWHRTGESILSLLRDPSKRKVPPQPLTPNQIVSTLFTSNFIGICFSRSLHYQF
YVWYFHTLPYLLWAMPARWLTHLLRLLVLGLIELSWNTYPSTSCSSAALHICHAVILLQL
WLGPQPFPKSTQHSKKAH
GenBank ID Protein 12803981
UniProtKB/Swiss-Prot ID Q92685
UniProtKB/Swiss-Prot Entry Name ALG3_HUMAN
PDB IDs Not Available
GenBank Gene ID BC002839
GeneCard ID ALG3
GenAtlas ID ALG3
HGNC ID HGNC:23056
References
General References Not Available