| Identification |
|---|
| HMDB Protein ID
| CDBP01477 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dolichyldiphosphatase 1 |
| Description
| Not Available |
| Synonyms
|
- Dolichyl pyrophosphate phosphatase 1
- SubName: Dolichyl pyrophosphate phosphatase 1, isoform CRA_d
- SubName: cDNA FLJ60437, highly similar to Dolichyldiphosphatase 1 (EC 3.6.1.43)
|
| Gene Name
| DOLPP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).
|
| GO Classification
|
| Biological Process |
| dolichyl diphosphate biosynthetic process |
| post-translational protein modification |
| protein N-linked glycosylation via asparagine |
| Cellular Component |
| integral to endoplasmic reticulum membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| Molecular Function |
| dolichyldiphosphatase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | N-Glycan biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.1 |
| SNPs
| DOLPP1 |
| Gene Sequence
|
>717 bp
ATGGCAGCGGACGGACAGTGCTCGCTCCCCGCTTCATGGCGGCCGGTGACCCTCACCCAC
GTCGAATATCCTGCAGGTGATCTCTCCGGCCACCTCCTTGCCTACCTGAGCCTCAGCCCT
GTATTTGTCATCGTCGGTTTCGTGACCCTCATCATATTTAAGCGGGAGCTGCACACGATC
TCCTTCCTTGGGGGCCTGGCACTGAACGAGGGGGTCAACTGGCTGATCAAAAACGTCATC
CAGGAGCCACGGCCCTGTGGAGGCCCCCACACAGCAGTGGGCACCAAGTACGGGATGCCC
TCCAGCCATTCCCAGTTTATGTGGTTCTTCTCCGTCTATTCCTTCCTTTTCCTGTATTTA
AGAATGCACCAAACAAACAACGCCAGGTTCCTGGACTTGCTGTGGAGGCACGTGCTCTCC
CTGGGACTCCTCGCTGTGGCCTTCCTAGTCTCCTACAGCAGGGTCTACCTGCTGTACCAC
ACCTGGAGCCAGGTGCTCTATGGAGGCATCGCTGGAGGCCTCATGGCCATCGCCTGGTTC
ATCTTCACCCAGGAGGTCCTCACCCCGCTGTTCCCCAGGATAGCAGCCTGGCCTGTCTCC
GAGTTCTTCCTAATCCGAGACACAAGCCTCATTCCCAACGTACTCTGGTTTGAGTACACG
GTAACCCGGGCAGAAGCCAGGAACAGACAACGCAAGCTGGGGACGAAACTGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 238 |
| Molecular Weight
| 22133.63 |
| Theoretical pI
| 9.552 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dolichyldiphosphatase 1
MAADGQCSLPASWRPVTLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTI
SFLGGLALNEGVNWLIKNVIQEPRPCGGPHTAVGTKYGMPSSHSQFMWFFSVYSFLFLYL
RMHQTNNARFLDLLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLMAIAWF
IFTQEVLTPLFPRIAAWPVSEFFLIRDTSLIPNVLWFEYTVTRAEARNRQRKLGTKLQ
|
| External Links |
|---|
| GenBank ID Protein
| 158254862 |
| UniProtKB/Swiss-Prot ID
| Q86YN1 |
| UniProtKB/Swiss-Prot Entry Name
| DOPP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK290713 |
| GeneCard ID
| DOLPP1 |
| GenAtlas ID
| DOLPP1 |
| HGNC ID
| HGNC:29565 |
| References |
|---|
| General References
| Not Available |