Identification |
HMDB Protein ID
| CDBP01468 |
Secondary Accession Numbers
| Not Available |
Name
| Glycylpeptide N-tetradecanoyltransferase 2 |
Description
| Not Available |
Synonyms
|
- Myristoyl-CoA:protein N-myristoyltransferase 2
- NMT 2
- Peptide N-myristoyltransferase 2
- Type II N-myristoyltransferase
|
Gene Name
| NMT2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in glycylpeptide N-tetradecanoyltransferase activity |
Specific Function
| Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
|
GO Classification
|
Biological Process |
protein lipoylation |
N-terminal protein myristoylation |
egress of virus within host cell |
Cellular Component |
cytosol |
plasma membrane |
Golgi apparatus |
Function |
transferase activity, transferring acyl groups |
transferase activity, transferring acyl groups other than amino-acyl groups |
acyltransferase activity |
n-acyltransferase activity |
glycylpeptide n-tetradecanoyltransferase activity |
catalytic activity |
transferase activity |
Molecular Function |
glycylpeptide N-tetradecanoyltransferase activity |
catalytic activity |
Process |
metabolic process |
macromolecule metabolic process |
protein amino acid lipidation |
macromolecule modification |
protein modification process |
n-terminal protein lipidation |
n-terminal protein myristoylation |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 10 |
Locus
| 10p13 |
SNPs
| NMT2 |
Gene Sequence
|
>1497 bp
ATGGCGGAGGACAGCGAGTCTGCGGCCAGCCAGCAGAGCCTGGAACTGGACGACCAGGAC
ACGTGCGGGATAGACGGGGACAATGAGGAGGAGACGGAGCACGCCAAAGGAAGTCCTGGA
GGGTATTTGGGAGCCAAAAAGAAAAAGAAGAAACAGAAGAGAAAAAAGGAGAAACCAAAT
TCCGGAGGCACCAAGTCAGACTCGGCATCTGATTCCCAGGAGATTAAAATTCAGCAGCCT
TCGAAAAATCCCAGTGTTCCAATGCAGAAGTTGCAGGATATCCAGAGAGCAATGGAGCTG
CTATCCGCATGCCAGGGCCCAGCCAGGAACATTGATGAGGCTGCAAAGCACAGATACCAG
TTTTGGGACACACAACCGGTACCAAAACTAGATGAAGTCATAACATCTCATGGTGCAATT
GAACCAGATAAAGACAACGTACGCCAAGAACCGTATTCTTTGCCACAGGGTTTTATGTGG
GACACTTTAGACTTGAGTGATGCCGAAGTGCTCAAGGAGTTATACACGTTGTTAAATGAG
AATTACGTAGAAGATGATGACAATATGTTCCGATTTGACTATTCACCCGAGTTCCTGTTG
TGGGCTCTGCGTCCACCAGGCTGGCTCCTGCAGTGGCACTGTGGGGTCAGAGTGTCTTCA
AATAAAAAACTGGTCGGGTTCATAAGTGCCATCCCAGCAAACATTCGGATTTATGACAGT
GTGAAGAAGATGGTAGAAATCAACTTTCTTTGTGTTCATAAGAAGTTGAGATCGAAACGG
GTAGCCCCAGTGCTAATCCGAGAGATCACTAGAAGAGTGAACCTGGAAGGGATCTTCCAG
GCTGTGTACACCGCGGGAGTGGTTCTTCCTAAGCCCATAGCCACATGCAGATACTGGCAT
CGATCACTAAACCCCAGAAAATTGGTAGAAGTGAAATTTTCTCACTTGAGTAGAAATATG
ACTTTACAGAGAACAATGAAGCTATACAGACTTCCAGATGTTACAAAGACTTCAGGTTTG
AGACCAATGGAACCAAAAGATATCAAATCAGTTCGAGAATTAATCAACACTTACCTGAAG
CAGTTTCATCTGGCTCCAGTGATGGATGAAGAGGAAGTAGCCCACTGGTTCCTCCCCCGG
GAGCACATTATTGACACGTTTGTAGTGGAGAGCCCCAACGGTAAACTGACTGATTTCCTG
AGCTTCTATACGCTCCCCTCCACGGTGATGCACCACCCTGCTCACAAGAGCCTCAAAGCC
GCCTACTCATTCTACAACATCCACACAGAGACGCCCCTGCTGGACCTCATGAGCGACGCG
CTCATCCTGGCTAAATCGAAAGGATTTGATGTATTCAATGCACTGGATTTGATGGAAAAT
AAGACATTCTTGGAAAAACTCAAGTTTGGTATAGGAGATGGCAATTTGCAGTATTACCTG
TACAATTGGAGGTGTCCAGGTACAGATTCTGAAAAGGTTGGACTAGTACTACAATAG
|
Protein Properties |
Number of Residues
| 498 |
Molecular Weight
| 56979.755 |
Theoretical pI
| 7.574 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Glycylpeptide N-tetradecanoyltransferase 2
MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPN
SGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQ
FWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNE
NYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDS
VKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWH
RSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLK
QFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKA
AYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYL
YNWRCPGTDSEKVGLVLQ
|
External Links |
GenBank ID Protein
| 3005065 |
UniProtKB/Swiss-Prot ID
| O60551 |
UniProtKB/Swiss-Prot Entry Name
| NMT2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF043325 |
GeneCard ID
| NMT2 |
GenAtlas ID
| NMT2 |
HGNC ID
| HGNC:7858 |
References |
General References
| Not Available |