| Identification |
|---|
| HMDB Protein ID
| CDBP01462 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thiamine-triphosphatase |
| Description
| Not Available |
| Synonyms
|
- ThTPase
|
| Gene Name
| THTPA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in adenylate cyclase activity |
| Specific Function
| Hydrolase highly specific for thiamine triphosphate (ThTP).
|
| GO Classification
|
| Biological Process |
| generation of precursor metabolites and energy |
| dephosphorylation |
| thiamine metabolic process |
| Cellular Component |
| cytosol |
| nucleolus |
| Function |
| catalytic activity |
| hydrolase activity |
| cyclase activity |
| adenylate cyclase activity |
| thiamin-triphosphatase activity |
| nucleoside-triphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| pyrophosphatase activity |
| Molecular Function |
| metal ion binding |
| thiamin-triphosphatase activity |
| Process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| nucleobase, nucleoside and nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| nucleotide metabolic process |
| cellular aromatic compound metabolic process |
| cellular metabolic process |
| thiamin and derivative metabolic process |
| thiamin metabolic process |
| camp biosynthetic process |
| purine nucleotide metabolic process |
| purine nucleotide biosynthetic process |
| metabolic process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Thiamine Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q11.2 |
| SNPs
| THTPA |
| Gene Sequence
|
>693 bp
ATGGCCCAGGGCTTGATTGAGGTGGAGCGAAAGTTCCTTCCAGGGCCTGGCACAGAGGAG
CGGCTGCAGGAGTTGGGGGGCACCCTGGAGTACCGGGTCACCTTCCGAGACACCTACTAT
GACACCCCTGAGCTGAGCCTCATGCAGGCTGACCACTGGCTGCGACGACGAGAGGATAGT
GGATGGGAGCTCAAATGTCCTGGAGCAGCAGGTGTCTTAGGACCCCACACGGAGTATAAG
GAACTCACAGCGGAACCTACAATTGTGGCCCAACTCTGTAAGGTGCTGCGGGCTGACGGC
CTGGGGGCTGGAGATGTGGCTGCTGTGCTGGGCCCACTGGGGCTGCAGGAAGTAGCTAGT
TTTGTGACTAAGCGGAGTGCCTGGAAGCTGGTGCTCTTGGGAGCTGATGAAGAGGAGCCA
CAGCTCAGGGTGGACTTGGATACAGCCGACTTTGGCTACGCTGTGGGTGAGGTAGAGGCC
CTGGTGCATGAGGAGGCTGAAGTACCAACTGCCCTAGAGAAGATCCACAGGCTCAGCAGC
ATGCTTGGTGTGCCTGCACAGGAGACAGCACCAGCCAAGCTGATTGTGTATCTACAGCGT
TTCCGGCCTCAAGACTATCAGCGCCTGCTAGAAGTGAACAGCTCCAGAGAGAGGCCACAG
GAGACTGAAGATCCTGACCACTGCCTGGGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 230 |
| Molecular Weight
| 25565.685 |
| Theoretical pI
| 4.816 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thiamine-triphosphatase
MAQGLIEVERKFLPGPGTEERLQELGGTLEYRVTFRDTYYDTPELSLMQADHWLRRREDS
GWELKCPGAAGVLGPHTEYKELTAEPTIVAQLCKVLRADGLGAGDVAAVLGPLGLQEVAS
FVTKRSAWKLVLLGADEEEPQLRVDLDTADFGYAVGEVEALVHEEAEVPTALEKIHRLSS
MLGVPAQETAPAKLIVYLQRFRPQDYQRLLEVNSSRERPQETEDPDHCLG
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9BU02 |
| UniProtKB/Swiss-Prot Entry Name
| THTPA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF432862 |
| GeneCard ID
| THTPA |
| GenAtlas ID
| THTPA |
| HGNC ID
| HGNC:18987 |
| References |
|---|
| General References
| Not Available |