Cannabis Compound Database: Showing Protein 72 kDa inositol polyphosphate 5-phosphatase (CDBP01460)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP01460

Secondary Accession Numbers

Not Available

Name

72 kDa inositol polyphosphate 5-phosphatase

Description

Not Available

Synonyms

Phosphatidylinositol polyphosphate 5-phosphatase type IV
Phosphatidylinositol-4,5-bisphosphate 5-phosphatase
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase

Gene Name

INPP5E

Protein Type

Enzyme

Biological Properties

General Function

Involved in inositol-polyphosphate 5-phosphatase activity

Specific Function

Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.

GO Classification

Biological Process
small molecule metabolic process
phosphatidylinositol biosynthetic process
phosphatidylinositol dephosphorylation
inositol phosphate dephosphorylation
phosphatidylinositol phosphorylation
positive regulation of neuron projection development
Cellular Component
cytosol
Golgi cisterna membrane
cytoskeleton
plasma membrane
cilium axoneme
Function
phosphoric ester hydrolase activity
phosphatase activity
inositol or phosphatidylinositol phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
Molecular Function
inositol-polyphosphate 5-phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Cellular Location

Cytoplasm
Peripheral membrane protein
Cytoplasmic side
Golgi apparatus
Golgi stack membrane
cytoskeleton
cilium axoneme

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phosphatidylinositol signaling system	Not Available
Phosphatidylinositol Phosphate Metabolism
Joubert syndrome		Not Available

Gene Properties

Chromosome Location

Locus

9q34.3

SNPs

INPP5E

Gene Sequence

>1935 bp
ATGCCGTCCAAGGCGGAGAATCTGCGGCCCTCCGAGCCGGCCCCGCAGCCGCCGGAAGGG
AGGACGCTCCAAGGACAGCTTCCCGGCGCTCCGCCGGCCCAGCGCGCGGGGTCCCCACCC
GATGCTCCGGGCTCCGAGAGCCCCGCGCTTGCCTGCAGCACTCCGGCCACGCCCAGCGGC
GAGGACCCGCCAGCCCGAGCAGCACCCATCGCCCCGCGGCCCCCCGCCAGGCCTCGACTG
GAGCGAGCCCTGTCCCTGGACGACAAGGGCTGGAGGAGGAGGCGTTTTCGAGGCAGCCAG
GAGGACCTGGAAGCCCGGAATGGGACCAGTCCCTCCAGGGGCTCAGTGCAGAGCGAGGGC
CCCGGGGCCCCCGCCCACAGCTGCTCCCCGCCCTGCCTGAGCACCTCCTTGCAGGAAATC
CCCAAGTCCCGCGGGGTCCTGAGCAGTGAGAGAGGGAGCCCGTCCTCGGGGGGTAACCCT
CTCTCTGGGGTGGCCAGCAGCTCCCCGAACCTCCCGCACAGAGACGCCGCCGTGGCGGGG
AGCTCGCCCAGGCTGCCCAGCCTGCTGCCCCCGCGCCCACCGCCTGCCCTGAGCCTGGAC
ATCGCCTCCGACTCCCTGAGGACAGCAAACAAGGTCGACTCGGATCTTGCAGACTACAAG
CTCCGCGCGCAGCCGCTCCTGGTGCGGGCCCACAGCAGCCTGGGCCCCGGCCGGCCGCGG
AGCCCCCTGGCCTGCGACGACTGTTCCCTTCGCTCGGCCAAATCCTCCTTCAGCCTCCTG
GCGCCCATCCGCAGCAAGGACGTCCGCAGCAGGAGTTACCTGGAGGGCAGCCTCCTGGCC
AGCGGGGCCCTGTTGGGGGCGGATGAGCTGGCCCGCTACTTCCCAGACCGGAACGTGGCA
CTCTTCGTGGCCACCTGGAACATGCAGGGCCAGAAGGAGCTCCCGCCCAGCCTGGACGAG
TTCCTGCTCCCAGCCGAGGCCGACTATGCCCAGGACCTGTATGTCATCGGGGTCCAGGAG
GGCTGTTCTGACACGCGGGAGTGGGAGACTCGTCTGCAGGAGACGCTGGGCCCGCACTAT
GTGCTGCTGTCCTCGGCGGCCCACGGCGTGCTCTACATGTCGCTCTTCATCCGCAGGGAC
CTCATCTGGTTCTGCTCAGAGGTGGAGTGCTCCACGGTGACCACACGCATCGTGTCTCAG
ATCAAGACCAAGGGGGCCTTGGGCATCAGCTTCACCTTTTTTGGCACTTCCTTCCTCTTC
ATCACGTCCCACTTCACCTCAGGTGACGGGAAGGTGGCGGAGCGGCTGCTGGACTACACC
AGGACTGTACAAGCCCTGGTCCTGCCCAGAAATGTGCCCGACACCAACCCCTATCGCTCC
AGCGCAGCGGACGTCACCACCCGCTTCGATGAGGTGTTCTGGTTTGGAGACTTCAACTTC
CGCCTGAGTGGCGGGCGCACAGTCGTGGACGCCCTCCTGTGCCAGGGCCTGGTGGTGGAC
GTGCCGGCGCTGCTGCAGCACGACCAGCTCATCCGGGAGATGCGGAAAGGGTCCATCTTC
AAGGGCTTCCAGGAGCCGGACATCCACTTCCTCCCATCATACAAGTTTGACATCGGGAAG
GACACGTACGACAGCACCTCCAAGCAGAGGACGCCCTCATACACGGACCGCGTCTTGTAC
AGAAGCCGCCACAAGGGTGACATCTGTCCTGTGAGCTACTCTTCCTGCCCCGGGATCAAG
ACGTCCGACCACCGCCCTGTGTATGGCCTCTTCCGGGTGAAAGTGAGGCCGGGGCGAGAC
AACATTCCGTTGGCAGCTGGCAAATTTGATAGAGAACTGTACTTACTAGGAATTAAAAGA
CGGATTTCGAAGGAGATTCAGAGGCAGCAAGCACTACAGAGTCAGAACTCCAGCACCATC
TGCTCCGTTTCTTGA

Protein Properties

Number of Residues

644

Molecular Weight

70204.435

Theoretical pI

8.96

Pfam Domain Function

Exo_endo_phos (PF03372 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>72 kDa inositol polyphosphate 5-phosphatase
MPSKAENLRPSEPAPQPPEGRTLQGQLPGAPPAQRAGSPPDAPGSESPALACSTPATPSG
EDPPARAAPIAPRPPARPRLERALSLDDKGWRRRRFRGSQEDLEARNGTSPSRGSVQSEG
PGAPAHSCSPPCLSTSLQEIPKSRGVLSSERGSPSSGGNPLSGVASSSPNLPHRDAAVAG
SSPRLPSLLPPRPPPALSLDIASDSLRTANKVDSDLADYKLRAQPLLVRAHSSLGPGRPR
SPLACDDCSLRSAKSSFSLLAPIRSKDVRSRSYLEGSLLASGALLGADELARYFPDRNVA
LFVATWNMQGQKELPPSLDEFLLPAEADYAQDLYVIGVQEGCSDRREWETRLQETLGPHY
VLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLF
ITSHFTSGDGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEVFWFGDFNF
RLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGSIFKGFQEPDIHFLPSYKFDIGK
DTYDSTSKQRTPSYTDRVLYRSRHKGDICPVSYSSCPGIKTSDHRPVYGLFRVKVRPGRD
NIPLAAGKFDRELYLLGIKRRISKEIQRQQALQSQNSSTICSVS

External Links

GenBank ID Protein

8925284

UniProtKB/Swiss-Prot ID

Q9NRR6

UniProtKB/Swiss-Prot Entry Name

INP5E_HUMAN

PDB IDs